A5090114689- Pregnancy and preeclampsia studies
- MicroRNA in disease regulation
- Mesenchymal stem cell research
- Extracellular vesicles in disease
- Cancer Cells and Metastasis
- Circular RNAs in diseases
- Cytokine Signaling Pathways and Interactions
- Cancer-related molecular mechanisms research
- Maternal and fetal healthcare
- Renal and related cancers
- Gestational Diabetes Research and Management
- Reproductive System and Pregnancy
- Birth, Development, and Health
- Fibroblast Growth Factor Research
- Ectopic Pregnancy Diagnosis and Management
- Lipid metabolism and biosynthesis
- Tumors and Oncological Cases
- Tissue Engineering and Regenerative Medicine
- Management of metastatic bone disease
- COVID-19 Impact on Reproduction
- Pancreatic function and diabetes
- Autophagy in Disease and Therapy
- Protease and Inhibitor Mechanisms
- Endometrial and Cervical Cancer Treatments
- Hippo pathway signaling and YAP/TAZ
Qingdao University
2017-2025
Affiliated Hospital of Qingdao University
2017-2025
Huazhong University of Science and Technology
2015-2019
Union Hospital
2019
Union Hospital
2015-2016
Homosapien collagen beta (1-O) galactosyl transferase 2 (COLGALT2) is an important enzyme during glycosylation, yet its biological functions in cancer are incompletely understood. Our previous study revealed that the osteosarcoma microenvironment, adipose-derived mesenchymal stem cells (ADSCs) demonstrate cancer-promoting effects, but exact mechanisms remain unclear. The aim of this was to investigate role COLGALT2 osteosarcoma-fostering effects ADSCs.
Ovarian cancer metastasizes to organs in the abdominal cavity, such as omentum that is a rich source of adipose-derived mesenchymal stem cells (ADSCs). In present, ADSCs have received more and attention for their roles development cancer. this study, we examined α-smooth muscle actin (α-SMA) expression carcinoma-associated fibroblast (CAF)-like differentiation capabilities from different patients. The effects on proliferation invasion epithelial ovarian (EOCCs) were also assessed vitro vivo....
Human amnion-derived mesenchymal stem cells (AD-MSCs) have been reported as a promising effective treatment to repair tissue. Trophoblast dysfunction during pregnancy is significantly involved in the pathogenesis of preeclampsia (PE). To understand how AD-MSCs regulated trophoblast function, we treated trophoblasts with AD-MSC-derived exosomes under hypoxic conditions. The markedly enhanced proliferation and autophagy. Furthermore, significant decrease EZH2 levels inactivation mTOR signaling...
Objective The objective of this study was to identify a novel gene and its potential mechanisms associated with susceptibility gestational diabetes mellitus (GDM) through an integrative approach.
Polycystic ovary syndrome (PCOS) is currently recognized as a condition that affects several systems in the body, including reproductive, endocrine, and cardiovascular systems. Prevalent among teenagers women of reproductive age. Prior research has demonstrated an elevation miR-34a-5p within follicular fluid (FF) PCOS. Despite this, precise mechanisms through which influences granulosa cells (GC) development function remain poorly characterized. Therefore, this study investigates involvement...
Osteosarcoma is the most common primary bone malignancy in children and young adults, but role of adipose-derived mesenchymal stem cells (ADSCs) rapid progression osteosarcoma still unclear. Here, we found that ADSCs promoted tumour growth invasion by increasing matrix metalloproteinase 2/9 (MMP2/9) expression cells. The persistent activation signal transducer activator transcription 3 (STAT3) has been shown to directly promote mediating a wide spectrum cellular responses, STAT3 was detected...
As shown in our previous studies, growth and metastasis of ovarian cancer can be regulated by adipose-derived mesenchymal stem cells (ADSCs). However, the underlying mechanism has not yet been revealed. In this study, a proteomics analysis was performed to compare protein expression treated with without ADSCs cells. Protein levels were altered due treatment ADSCs. Thymosin beta 4 X-linked (TMSB4X) changed dramatically, identified as one most important candidate molecules contributing...
Abstract Our previous studies have shown that the Adipose‐derived mesenchymal stem cells (ADSCs) can regulate metastasis and development of ovarian cancer. However, its specific mechanism has yet to be fully revealed. In this study, an RNA‐seq approach was adopted compare differences in mRNA levels cancer being given or not ADSCs. The level paired box 8 (PAX8) changed significantly confirmed as important factor tumour‐inducing effect comparison with cultured common growth medium, those...
Spinal metastasis is a major challenge in patients with advanced lung cancer, but the mechanisms organotropism of are still unclear. Adipose-derived mesenchymal stem cells (ADSCs) exhibit cancer-promoting properties that influence tumour microenvironment; however, there no research on ADSCs from epidural fat thus far.In this study, we isolated and identified adipose tissue for first time. We examined activation treated cancer cell-conditioned medium by immunohistochemistry, western blot...
Preeclampsia (PE), a pregnancy disorder that affects 5-7% of pregnant women, is among the primary causes for maternal and perinatal mortality. PE believed to be associated with insufficient invasion villous extravillous trophoblasts (EVTs), which hampers uterine spiral artery remodeling finally induces PE. But mechanism responsible reduction trophoblast remains unclear. In this study, placental tissues taken from healthy donors patients were used evaluate miR-326 expression; CCK8 colony...
Ovarian cancer (OC) is the deadliest gynecological malignancy. The pathogenesis of molecular in epithelial ovarian (EOC), main histological type OC, has not been completely defined. Enhancer rudimentary homolog (ERH) had reported to participate transcriptional regulation, mRNA splicing, DNA repair and synthesis by binding a variety proteins. In this study, immunohistochemical staining revealed that protein expression ERH was associated with type, lymph node metastasis pathological grade EOC...
Ovarian cancer is the fifth most common cause of cancer-related deaths and accounts for 3% cases occurring in women. Therefore, determining underlying genes that can promote ovarian progression great urgency. It has been reported RHPN2 promotes tumour various types cancer, but its role pathogenesis remains unknown. In this study, bioinformatic datasets were used to predict expression clinical samples determine relationship between prognosis patients. Clinical verify prediction....
Preeclampsia is a significant contributor for maternal or fetal morbidity and mortality, which characterized by reduced invasion capacity of trophoblasts regulated extracellular matrix (ECM). It still under investigation whether chorionic villus-derived mesenchymal stem cells (CVMSC) could affect the functionality trophoblasts. In this study, CVMSC-derived exosomes were isolated; their effect on was investigated based CCK8 assay, migration apoptosis detection. And underlying mechanism using...
Trophoblast dysfunction during pregnancy is fundamentally involved in preeclampsia. Several studies have revealed that human chorionic villous mesenchymal stem cells (CV-MSCs) could regulate trophoblasts function. To understand how trophoblast function, we treated with CV-MSC supernatant under hypoxic conditions. Treatment markedly enhanced proliferation and invasion augmented autophagy. Transcriptome pathway analyses of before after treatment JAK2/STAT3 signalling as an upstream regulator....
Abstract Background Patients with abnormally invasive placenta (AIP) are at high risk of massive postpartum hemorrhage. Resuscitative endovascular balloon occlusion the aorta (REBOA), as an adjunct therapeutic strategy for hemostasis, offers obstetrician alternative treating patients AIP. This study aimed to evaluate role REBOA in hemorrhage control Methods was a historical cohort prospectively collected data between January 2014 July 2021 single tertiary center. According delivery...
Human chorionic villous mesenchymal stem cells (CV-MSCs) are a promising and effective therapeutic option for tissue injury. Vascular dysfunction during pregnancies is significantly involved in the pathogenesis of preeclampsia (PE). This work aims to investigate how CV-MSCs regulate function vascular endothelial cells. In this study, RNA-seq analysis was used examine changes HUVECs treated with CV-MSC conditioned medium (CM). We examined levels ABCA9 AKT signaling human umbilical vein...
Background The extensive spread of coronavirus disease 2019 (COVID-19) has led to a rapid increase in global mortality. Preeclampsia is commonly observed pregnancy ailment characterized by high maternal morbidity and mortality rates, addition the restriction fetal growth within uterine environment. Pregnant individuals afflicted with vascular disorders, including preeclampsia, exhibit an increased susceptibility severe acute respiratory syndrome 2 (SARS-CoV-2) infection via mechanisms that...
Preeclampsia, a significant cause of maternal and perinatal morbidity mortality, remains poorly understood, in terms its pathogenesis. This study aims to uncover novel effective biomarkers for preeclampsia by conducting comparative analysis differential proteins placentas from early onset (EOPE) normal pregnancies. Utilizing tandem mass tag (TMT)-based quantitative proteomics, we identified differentially expressed placental tissues 15 EOPE patients pregnant women. These were subsequently...
Amniotic mesenchymal stem cells (AMSCs) have been demonstrated as effective in tissue repair and regeneration. Trophoblast dysfunction is associated with several types of pregnancy complications. The aim this study to investigate the effects AMSCs on biological activities human trophoblasts, well their molecular mechanisms.