A5100449880- Caveolin-1 and cellular processes
- Acute Myeloid Leukemia Research
- Cancer-related molecular mechanisms research
- Mesenchymal stem cell research
- Cancer, Lipids, and Metabolism
- Cellular transport and secretion
- MicroRNA in disease regulation
- Fungal and yeast genetics research
- Inflammatory Bowel Disease
- Microtubule and mitosis dynamics
- Immune Response and Inflammation
- Retinoids in leukemia and cellular processes
- RNA modifications and cancer
- Extracellular vesicles in disease
- Bone health and treatments
- Circular RNAs in diseases
- Plant Reproductive Biology
- Pregnancy and preeclampsia studies
- Immune cells in cancer
- Alzheimer's disease research and treatments
- Nutrition and Health in Aging
- Glioma Diagnosis and Treatment
- Body Composition Measurement Techniques
- Telomeres, Telomerase, and Senescence
- Bone and Dental Protein Studies
Qingdao University
2021-2025
The Ohio State University
2005-2024
Nanjing Drum Tower Hospital
2022-2024
Beijing Jishuitan Hospital
2018-2024
Capital Medical University
2024
Peking University
2009-2024
Sichuan University
2024
Brown University
2020-2024
Rhode Island Hospital
2020-2024
First Affiliated Hospital of Bengbu Medical College
2021-2024
Patients with ulcerative colitis (UC) have a high prevalence of mental disorders, such as depression and anxiety. Gut microbiota imbalance disturbed metabolism been suggested to play an important role in either UC or disorders. However, little is known about their detailed multi-omics characteristics patients depression/anxiety. In this prospective observational study, 240 Chinese were enrolled, including 129 active (69 Phase 1 60 2; divided into depression/non-depression anxiety/non-anxiety...
Highlights•Structures of anillin and Mid1 reveal the cryptic membrane-associating elements•Synergistic action RhoA phospholipids anchor at cleavage furrow•Reconstitution actin filament-plasma membrane linkage mediated by anillin•High affinity to PI(4,5)P2 helps target dimeric furrow membraneSummaryAnillins are scaffold proteins that play key roles in anchorage contractile ring cell equator during cytokinesis animals fungi, respectively. Here, we report crystal structures functional analysis...
The pH in the aqueous pores of poly(lactide-co-glycolide) (PLGA) matrix, also referred to as microclimate (μpH), is often uncontrolled, ranging from highly acidic neutral range. μpH distribution inside protein-encapsulated PLGA microspheres was quantitatively evaluated using confocal laser scanning microscopy. fluorescent response Lysosensor yellow/blue dextran used map influenced by presence encapsulated protein. nonprotonated form pyridyl group on fluorescence probe at responsible for...
Diabetic osteoporosis (DO) presents significant clinical challenges. This study aimed to investigate the potential of magnetic nanoparticle-enhanced extracellular vesicles (GMNP
The total water intake was insufficient among older individuals over 75 in China, impacting their body composition, hydration status, and metabolism.
Abstract Background A major endogenous protective mechanism in many organs against ischemia/reperfusion (I/R) injury is ischemic preconditioning (IPC). By moderately uncoupling the mitochondrial respiratory chain and decreasing production of reactive oxygen species (ROS), IPC reduces apoptosis induced by I/R reducing cytochrome c release from mitochondria. One element believed to contribute reduce ROS protein UCP2 (and UCP3 heart). Although its implication brain has been shown vitro, no vivo...
Retinoblastoma is a common intraocular malignancy that occurs during childhood. MicroRNAs play critical roles in the regulation of retinoblastoma initiation and progression, aberrant expression miR-613 had been reported various types cancer. However, role mechanism its function are still unclear. In this study, we found was downregulated tissues cell lines. Overexpression suppressed proliferation, migration, invasion induced cycle arrest vitro. Additionally, overexpressed also inhibited...
To explore the effect of physical exercise on learning burnout in adolescents, and to reveal mediating self-efficacy between different amounts burnout.A total 610 adolescents from 5 primary middle schools Chongqing, China were investigated with Physical Exercise Rating Scale (PARS-3), General Self-Efficacy (GSES), Learning Burnout (LBS). The SPSS21.0 AMOS21.0 statistical software used process analyze data.(1) amount boys was significantly higher than that girls, but there no significant...
Accumulated evidence supports that long non-coding RNAs (lncRNAs) are involved significantly in the development of human cancers. Enhancer (eRNAs), a subtype lncRNAs, have recently attracted much attention about their roles carcinogenesis. Colon adenocarcinoma is one most commonly diagnosed tumors with unfavorable prognosis. It highlights great significance screening and identifying novel biomarkers. More importantly, it remains to be elucidated respect function eRNAs colon adenocarcinoma,...
Ulcerative colitis (UC) is a chronic idiopathic inflammatory disorder affecting the large intestine. Inflammatory biomarkers in UC are nonspecific, simple and cheap biomarker needed. Our study aimed to explore possible relationship of platelet-to-lymphocyte ratio (PLR) neutrophil-to-lymphocyte (NLR) with disease activity UC. Furthermore, correlation PLR or NLR other clinical indicators was evaluated.We retrospectively reviewed data patients presented Affiliated Hospital Nanjing TCM...
Abstract Background Malnutrition is related to impaired oral health and function that causes poor dietary intake, declining the general of older adults. The role intake in association between nutritional status Chinese adults (aged 75 above) was examined this cross-sectional study. Methods Through randomized cluster sampling method, 267 living rural areas Qingdao, Shandong 81.4 ± 4.3, 75–94 years) were chosen as primary research participants. A Mini Nutritional Assessment - Short Form used...
Plasmodium falciparum malaria is a significant public health problem in Comoros, and artemisinin combination therapy (ACT) remains the first choice for treating acute uncomplicated P. falciparum. The emergence spread of artemisinin-resistant Southeast Asia, associated with mutations K13-propeller gene, poses potential threat to ACT efficacy. Detection gene may provide first-hand information on changes parasite susceptibility artemisinin. objective this study determinate prevalence mutant...
In Comoros, the widespread of chloroquine (CQ)-resistant Plasmodium falciparum populations was a major obstacle to malaria control, which led official withdrawal CQ in 2004. Continuous monitoring CQ-resistant markers P. resistant transporter (pfcrt) and multiple drug resistance 1 (pfmdr-1) is necessary inder obtain first-hand information on susceptibility parasite field. The objective this study assess prevalence evolution CQ-resistance Comoros' Grande Comore island after CQ. A total 207...
Although numerous toxicological studies have been performed on carbon nanotubes (CNTs), a few investigated their secondary and indirect effects beyond the primary target tissues/organs. Here, cascade of events are investigated: initiating event subsequent key necessary for development phenotypes, namely CNT-induced pro-inflammatory iron homeostasis red blood cell formation, which linked to anemia inflammation (AI). A panel CNTs prepared including pristine multiwall (P-MWCNTs), aminated...
Extracellular vesicles derived from bone marrow mesenchymal stem cells (BMSC-EVs) are emerged as carriers of therapeutic targets against disorders, yet its isolation and purification limited with recent techniques. Magnetic nanoparticles (MNPs) can load EVs a unique targeted drug delivery system. We constructed gold-coated magnetic (GMNPs) by decorating the surface Fe3O4@SiO2 core silica shell poly(ethylene glycol) (PEG)-aldehyde (CHO) examined role BMSC-EVs loaded on GMNPs in diabetic...
Human osteoarthritic cartilage contains not only chondrocytes (OACs), but also mesenchymal stromal cells (OA-MSCs), whose abundance increases during osteoarthritis (OA). However, it is clear how OA-MSC contributes to OA pathogenesis. Here, we show that aging plays an important role in cell senescence, fibrosis, and inflammation cartilage. Protein array analysis indicates expresses pro-inflammatory senescence associated secretory phenotype (SASP) including IL-1β, IL-6, IL-8, CXCL1, 5, 6,...
Acute myeloid leukemia (AML) is a heterogeneous disease with poor prognosis. The current risk stratification system essential but remains insufficient to select the best schedules. Cysteine-rich protein 1 (CSRP1) member of CSRP family and associated clinicopathological features in many tumors. This study aimed explore clinical significance molecular mechanisms cysteine- glycine-rich AML. RT-qPCR was used detect relative expression CSRP1 our cohort. Functional enrichment analysis...
Increasing studies have indicated the critical roles of long non-coding RNAs (lncRNAs) in tumorigenesis cancers. LncRNA AGAP2 antisense RNA 1 (AGAP2-AS1) can serve as an oncogenic role some cancers, including prostate cancer (PCa). However, underling mechanism such lncRNA PCa has not been fully studied. Therefore, it is meaningful to investigate and underlying AGAP2-AS1 PCa. was confirmed be highly expressed cells. Functionally, silencing inhibited cell proliferation, migration, invasion...
Objective: To investigate the prognostic value of arachidonate lipoxygenases 5 (ALOX5) expression and methylation, explore immune functions in low-grade glioma (LGG). Materials Methods: Using efficient bioinformatics approaches, differential association its with clinicopathological characteristics were evaluated. Then, we analyzed significance methylation level followed by cell infiltration analysis. The functional enrichment analysis was conducted to determine possible regulatory pathways...
Caveolin-2 (Cav-2), a member of caveolin protein family, is largely different from better known caveolin-1 (Cav-1) and thus might play distinct functions. Here, we provide the first genetic evidence suggesting that host-expressed Cav-2 promotes subcutaneous tumor growth tumor-induced neovascularization using two independent syngeneic mouse models. Host deficiency in resulted defective reduced subcutaneously implanted Lewis lung carcinoma (LLC) B16-F10 melanoma tumors, respectively....
The epigenetic regulator additional sex combs-like 1 (ASXL1) is an adverse prognostic factor in acute myeloid leukemia (AML). However, the mutational spectrum and factors of ASXL1-mutated (ASXL1+) AML are largely unknown. We aim to evaluate risk influencing prognosis ASXL1+ AML. performed next-generation sequencing (NGS) 1047 cases de novo discovered 91 (8.7%). Log-Rank test Kaplan-Meier were used survival rate, Cox regression model was analyze multivariate analysis. In a total AML, 86% had...
BACKGROUND Mesenchymal stem cells (MSCs) have emerged as an attractive alternative to modulating immune response after transplantation. Recent studies shown that systemically administered MSCs enter the inflamed intestine. In present study, we propose a strategy improve efficacy of MSC-based cellular therapy for inflammation using Astragaloside and Baicalein enhance cell survival, inhibit apoptosis, modulate inflammatory in vitro. MATERIAL AND METHODS were induced with lipopolysaccharide...