A5018758364- Asymmetric Synthesis and Catalysis
- Catalytic C–H Functionalization Methods
- Nutrition and Health in Aging
- Catalytic Alkyne Reactions
- Soil Carbon and Nitrogen Dynamics
- Dental Health and Care Utilization
- Synthetic Organic Chemistry Methods
- Environmental and Agricultural Sciences
- Dysphagia Assessment and Management
- Arsenic contamination and mitigation
- Mine drainage and remediation techniques
- CO2 Sequestration and Geologic Interactions
- Cyclopropane Reaction Mechanisms
- Organoboron and organosilicon chemistry
- Mining and Resource Management
- Evaluation Methods in Various Fields
- Evaluation and Optimization Models
- Hydrological Forecasting Using AI
- Construction Project Management and Performance
- Agriculture, Soil, Plant Science
- Chromium effects and bioremediation
- Geochemistry and Geochronology of Asian Mineral Deposits
- Dental Research and COVID-19
- Iron oxide chemistry and applications
- Corneal Surgery and Treatments
Qingdao University
2011-2024
Hubei University
2022-2023
Shanghai Institute of Organic Chemistry
2017-2022
University of Chinese Academy of Sciences
2018-2022
Tongji University
2022
Tongji Hospital
2022
Chinese Academy of Sciences
2017
A direct catalytic asymmetric vinylogous Mannich-type reaction has been disclosed in good yield, excellent regio-, diastereo- and enantioselectivity. The key to control the regioselectivity is combination of a bulky N-acylpyrazole bisphosphine ligand. system was extended bisvinylogous by changing synthetic utility products demonstrated several transformations.
A catalytic asymmetric vinylogous Mannich-type reaction of γ-halo-α,β-unsaturated N-acylpyrazoles and N-Boc-aldimines was disclosed, which afforded an array halogenated (F-, Cl-, Br-) allylic stereogenic carbon centers in high yields with good to regio-, diastereo-, enantioselectivities. The brominated product served as a suitable electrophile for common SN2 nucleophilic substitution copper-mediated SN2' alkylation metal reagents. utility present methodology demonstrated by the synthesis...
Abstract Chiral 2,3‐allenols were constructed through copper(I)‐catalyzed asymmetric direct alkynylogous aldol reaction. With aromatic and heteroaromatic aldehydes, the reaction with ( R )‐DTBM‐SEGPHOS as ligand proceeded smoothly to furnish products in excellent regioselectivity good high diastereoselectivity enantioselectivity. In cases of aliphatic esters but‐2‐yn‐1‐ol substrates , )‐Ph‐BPE found be crucial get regio‐ diastereoselectivity. The produced chiral are easily transformed into...
Introduction: Within the global framework of carbon emissions constraints, digital economy has become a new strategy for cities to achieve sustainable development. Scholarly literature exploring spatial spillover and mechanisms on is notably scarce. Methods: To estimate impact emissions, this paper conducted analysis with Dubin model panel data 215 in China from 2011 2019. Results: The results show that there growing regional agglomeration economy, whereas evolution displays low liquidity...
Abstract Background Malnutrition is related to impaired oral health and function that causes poor dietary intake, declining the general of older adults. The role intake in association between nutritional status Chinese adults (aged 75 above) was examined this cross-sectional study. Methods Through randomized cluster sampling method, 267 living rural areas Qingdao, Shandong 81.4 ± 4.3, 75–94 years) were chosen as primary research participants. A Mini Nutritional Assessment - Short Form used...
By using commercially available 1,4-pentadiene as a pronucleophile, copper(I)-catalyzed regioselective asymmetric allylation of ketones is achieved. A variety chiral tertiary alcohols bearing terminal (Z)-1,3-diene unit are generated in high (Z)/(E) ratio and enantioselectivity. Both aromatic aliphatic serve suitable substrates. Furthermore, the reactions with (E)-C1(alkyl)-1,4-dienes proceed moderate yields acceptable enantioselectivity but low (Z,E)/others ratio, which demonstrates partial...
Soil ammonia oxidation, which acts as the first and rate-limiting step of nitrification, is driven by ammonia-oxidizing bacteria (AOB), archaea (AOA) complete oxidizer (comammox, amoA gene clade-A clade-B). Straw returning, widely used ecological technology in China, an effective measure for promoting straw decomposition soil nutrient cycling when combined with earthworm addition. However, effects returning addition on oxidizers remain poorly understood.A 2-year plot experiment was conducted...
Herein, a copper(I)-catalyzed alkynylogous Mannich-type reaction is developed, which starts from pyrazoleamides of alkynyl-substituted acetic acids and provides an array chiral α-allenylamine derivatives in high regio-, diastereo-, enantioselectivities. This enjoys broad substrate scopes on both N-Boc-aldimines. Moreover, cascade cyclization but-2-ynoic acid disclosed, involves α-selective as key step delivers series β-lactams containing pyrazole moiety enantioselectivity. In light some...
Age-related macular degeneration (AMD) is a major vision-threatening disease. Although mesenchymal stem cells (MSCs) exhibit beneficial neural protective effects, their limited differentiation capacity in vivo attenuates therapeutic function. Therefore, the of MSCs into retinal pigment epithelial (RPE) vitro and subsequent transplantation subretinal space expected to improve outcome cell therapy. Here, we transdifferentiated human umbilical cord (hUCMSCs) induced RPE (iRPE) using cocktail...
Main observation and conclusion ( E )‐α,β‐Unsaturated pyrazoleamides undergo facile dienolization to furnish copper(I)‐(1 Z ,3 )‐dienolates as the major in presence of a copper(I)‐( R )‐DTBM‐SEGPHOS catalyst Et 3 N, which react with aldimines afford syn ‐vinylogous products diastereoisomers high regio‐ enantioselectivities. In some cases, diastereoselectivity is low, possibly due low ratio )‐dienolates. )‐Allylcopper(I) species proposed effective intermediates, may form an equilibrium...
Thiosulfate influences the bioreduction and migration transformation of arsenic (As) iron (Fe) in groundwater environments. The aim this study was to investigate impact microbially-mediated sulfur cycling on interaction As Fe. Microcosm experiments were conducted, including thiosulfate, As(V), Fe(III) by Citrobacter sp. JH012–1, as well influence thiosulfate input at different initial arsenate concentrations As(V) Fe(III). results demonstrate that JH012–1 exhibited strong reduction...
Abstract Chiral 2,3‐allenols were constructed through copper(I)‐catalyzed asymmetric direct alkynylogous aldol reaction. With aromatic and heteroaromatic aldehydes, the reaction with ( R )‐DTBM‐SEGPHOS as ligand proceeded smoothly to furnish products in excellent regioselectivity good high diastereoselectivity enantioselectivity. In cases of aliphatic esters but‐2‐yn‐1‐ol substrates , )‐Ph‐BPE found be crucial get regio‐ diastereoselectivity. The produced chiral are easily transformed into...
Background and objectives Diet plays a crucial role in cognition. Mild cognitive impairment has high prevalence rural elderly people. However, few studies have investigated the relationship between diet mild among people China. The study evaluated association risk of them. Methods design In this cross-sectional study, we enrolled 1262 participants (≥65 years) living Qingdao, Cognitive function was assessed using Mini-Mental State Examination, dietary consumption measured food frequency...
In this work, a method of enhanced packed-bed microbial oxidation-neutralization has been employed to treat Fe2+-rich acid mine drainage. The features the use large number immobile Acidithiobacillus ferrooxidans (A. ferrooxidans) in bioreactor promote oxidation Fe2+ Fe3+. Results show that when influent concentration is about 900 mg/L and efficiency tends 100%, maximum rate bio-ceramsite, bio-volcanic stone, bio-activated carbon packed columns are 301 mg/(L·h), 234 139 respectively. Compared...
Removal of lake sediment has been shown to be an effective method for restoration. High phosphorus (P) content makes it possible provide fertility agricultural production. However, little research focused on the responses soil-phosphorus-related microbial community sediment-derived fertilizer enriched in content. The phoD-harboring gene, important global cycle, encodes alkaline phosphatase hydrolyzing organic P soil. Accordingly, a plot experiment was performed compare effects four different...