A5077083488- Retinal Diseases and Treatments
- Remote Sensing and Land Use
- Synthetic Aperture Radar (SAR) Applications and Techniques
- earthquake and tectonic studies
- Retinal Development and Disorders
- Retinal Imaging and Analysis
- Remote-Sensing Image Classification
- Earthquake Detection and Analysis
- Landslides and related hazards
- Glaucoma and retinal disorders
- Cryospheric studies and observations
- Advanced Glycation End Products research
- Neuroinflammation and Neurodegeneration Mechanisms
- Seismic Imaging and Inversion Techniques
- Retinal and Optic Conditions
- Geological and Geochemical Analysis
- Natural Fiber Reinforced Composites
- Retinal and Macular Surgery
- Geological and Geophysical Studies
- Retinopathy of Prematurity Studies
- Corneal Surgery and Treatments
- Membrane Separation and Gas Transport
- Seismology and Earthquake Studies
- Advanced Cellulose Research Studies
- Ubiquitin and proteasome pathways
Chinese University of Hong Kong, Shenzhen
2024-2025
Shanghai Jiao Tong University
2007-2024
Shanghai First People's Hospital
2019-2024
Shanghai Eye Disease Prevention & Treatment Center
2020-2024
Dalian University of Technology
2023-2024
Qilu University of Technology
2021-2024
Shandong Academy of Sciences
2021-2024
Shanghai Clinical Research Center
2023-2024
Chinese University of Hong Kong
2024
Université du Québec en Abitibi-Témiscamingue
2019-2024
Increased permeability of retinal capillary endothelial cells is a key feature in the progression diabetic retinopathy (DR). Precisely why and how diabetes causes dysfunction not well understood, making it challenging to explore more advanced therapeutics.Cell proliferation was assessed by Cell Counting Kit-8 assay. Ferroptosis evaluated measuring lipid reactive oxygen species levels flow cytometry determining malondialdehyde, superoxide dismutase, glutathione peroxidase through biochemical...
Diabetic retinopathy (DR) is one of the leading causes blindness in world, and timely prevention treatment are very important. Previously, we found that a neurodegenerative factor, Glia maturation factor-β (GMFB), was upregulated vitreous at early stage diabetes, which may play an important role pathogenesis. Here, high glucose environment, large amounts GMFB protein can be secreted vitreous, translocates ATPase ATP6V1A from lysosome, preventing its assembly alkalinizing lysosome retinal...
To explore and evaluate the protective effect of erythropoietin (EPO) on retinal cells chemically induced diabetic rats after EPO was injected intravitreally at onset diabetes.Diabetes in Sprague-Dawley by intraperitoneal injection streptozotocin (STZ). At diabetes, a single intravitreal (0.05-200 ng/eye) performed. In following 6 weeks, blood barrier (BRB) evaluated Evans blue permeation (EBP). Retinal cell death different layers determined terminal deoxynucleotidyl transferase-mediated...
Abstract Subretinal fibrosis remains a major obstacle to the management of neovascular age-related macular degeneration. Choroidal pericytes were found be significant source subretinal fibrosis, but underlying mechanisms pericyte-myofibroblast transition (PMT) remain largely unknown. The goal this study was explore role and potential by which PMT contributes fibrosis. neovascularization (CNV) induced laser photocoagulation in transgenic mice with collagen1α1-green fluorescent protein...
Microglial activation and melatonin protection have been reported in diabetic retinopathy (DR). Whether could regulate microglia to protect the inner blood-retinal barrier (iBRB) remains unknown. In this study, role of iBRB breakdown mechanisms melatonin's regulation on were explored. rat retinas, activated proliferated migrated from retina outer retina, accompanied by obvious morphological changes. Meanwhile, significant leakage albumin was evidenced at site close interaction between...
Subretinal fibrosis (SF) accounts for vision loss in patients with neovascular age-related macular degeneration (nAMD) even treated adequate intravitreal injection of anti-vascular endothelial growth factor (anti-VEGF) drugs. Currently, there is no treatment available to prevent or treat SF caused by nAMD.This study aims investigate the potential effects luteolin on and epithelial-mesenchymal transition (EMT) as well underlying molecular pathways both vivo vitro.Seven-week-old male C57BL/6J...
Abstract Polymer‐based membrane technology holds immense promise for CO 2 separation. However, it faces persistent challenges, including the high pressure‐induced plasticization and permeability‐selectivity trade‐offs, which significantly hinder development of polymeric membranes. To tackle this issue, we synthesized a novel polyimide 6FDA‐DAT:DABA(6FDD) containing triptycene carboxylic groups. Upon de‐carboxylation induced cross‐linking, demonstrated simultaneous enhancement gas...
Purpose.: To characterize the neuroprotective mechanisms of erythropoietin (EPO) against stress glyoxal-advanced glycation end products (AGEs) in retinal neuronal cells. Methods.: Rat organ culture, primary neuron and cell line (R28 cell) culture under glyoxal-AGEs insult were used as vitro models. Exogenous EPO was applied to these Retinal death assessed by TUNEL, ethidium bromide/acridine orange staining, viability assay. R28 proliferation evaluated BrdU incorporation propidium iodide...
Compared with optical sensors, Synthetic Aperture Radar (SAR) can provide important damage information due to its ability map areas affected by earthquakes independently from weather conditions and solar illumination. In 2013, a new TerraSAR-X mode named staring spotlight (ST), whose azimuth resolution was improved 0.24 m, introduced for various applications. This data source made it possible extract detailed individual buildings. this paper, we present concept building assessment using...
The preparation of bio-composites based on engineering plastic is always restricted by the low thermal stability lignocellulose. In this study, lignocellulose was improved boric acid modification. Then, borated characterized to analyze mechanism involved in improvement stability. Furthermore, untreated and combined with polyamide 6 produce bio-composites. effects content modification color, mechanical properties resulting composites were compared analyzed. Boric protected from degradation,...
Little is known about the associations between vision impairment, hearing and cognitive function. The aim of this study was to examine whether impairment were associated with a high risk for in middle-aged older Chinese adults.A total 13 914 adults from China Health Retirement Longitudinal Study (CHARLS) baseline selected analysis. Sensory assessed single self-report question, we categorized sensory into four groups: no dual impairment. Cognitive assessment covered memory, mental state,...
Abstract The pathophysiology of diabetic retinopathy (DR) was complex. Under hyperglycemic conditions, the release proinflammatory cytokines and adhesion leukocytes to retinal capillaries contribute endothelial damage subsequent increase in vascular permeability resulting macular edema. Melatonin, produced retina regulate redox reactions dopamine metabolism, plays protective roles against inflammation oxidative stress. Considering its anti‐inflammatory antioxidative properties, melatonin...
AIM: To investigate the changes of Iba-1 and other potential markers for microglia activation in experimental diabetic retinopathy (DR). METHODS: Male Sprague-Dawley rats were rendered diabetes via intraperitoneal injection streptozotocin. The retinas harvested at 1 to 24wk after onset. Hypoxia-treated mouse microglial cell line (BV2 cells) was employed as vitro model mimic condition. expressions Iba-1, CD11b, ICAM-1 well inflammatory factors examined with real-time polymerase chain...