A5100711300- MicroRNA in disease regulation
- Circular RNAs in diseases
- Cancer-related molecular mechanisms research
- Kruppel-like factors research
- Cancer, Lipids, and Metabolism
- RNA modifications and cancer
- Ubiquitin and proteasome pathways
- Cell death mechanisms and regulation
- Tissue Engineering and Regenerative Medicine
- Cancer-related Molecular Pathways
- Mechanisms of cancer metastasis
- Cancer Mechanisms and Therapy
- Melanoma and MAPK Pathways
- Curcumin's Biomedical Applications
- Histone Deacetylase Inhibitors Research
- Nanoparticle-Based Drug Delivery
- Nerve injury and regeneration
- Lipid metabolism and disorders
- TGF-β signaling in diseases
- Trace Elements in Health
- Quinazolinone synthesis and applications
- Signaling Pathways in Disease
- Genetic Syndromes and Imprinting
- Protein Degradation and Inhibitors
- PARP inhibition in cancer therapy
Dalian Medical University
2021-2024
Second Affiliated Hospital of Dalian Medical University
2021-2024
Zhongda Hospital Southeast University
2024
Bengbu Medical College
2023
Shaanxi Normal University
2023
Northwestern Polytechnical University
2019-2023
Huazhong University of Science and Technology
2022
First Affiliated Hospital of Jinan University
2022
Jiangsu Province Hospital
2017-2022
Shanghai Jiao Tong University
2016-2022
Through the synergistic effect of dry air and surfactants, high-quality, pinhole free perovskite films prepared from aqueous inks (Pb(NO 3 ) 2 /H O) can be easily obtained.
Previous studies have revealed the critical role of transglutaminase 2 (TGM2) as a potential therapeutic target in cancers, but oncogenic roles and underlying mechanisms TGM2 gastric cancer (GC) are not fully understood. In this study, we examined mechanism GC.Western blotting, immunohistochemistry, CCK8, colony formation transwell assays were used to measure expression GC cells tissues examine vitro GC. Xenograft vivo metastasis experiments performed Gene set enrichment analysis,...
Breast cancer metastasis suppressor 1 (BRMS1) was originally identified as an active in human breast cancer. Loss of BRMS1 expression correlates with tumor progression, and suppresses several steps required for metastasis. However, the role hepatocellular carcinoma (HCC) remains elusive. In this study, we found that level significantly down-regulated HCC tissues. Expression SK-Hep1 cells did not affect cell growth under normal culture conditions, but sensitized to apoptosis induced by serum...
This study was aimed at identifying the role of zinc finger protein 143 (ZNF143) in gastric cancer (GC) progression. The impact ZNF143 on proliferation ability and apoptosis GC cells detected. expression related targeted genes determined using Western blot analysis. reactive oxygen species (ROS) level examined ROS generation assay. vivo tumor xenograft ectopic overexpression promoted cells, while its knockdown reduced effect vitro. downregulation facilitated cell apoptosis. decreased...
<b>Objective:</b> Osteosarcoma is a common primary highly malignant bone tumor. Kinesin family member 18B (<i>KIF18B</i>) has been identified as potential oncogene involved in the development and metastasis of several cancer types. While KIF18B overexpression osteosarcoma tissue clearly detected, its specific function disease process remains to be established. <b>Methods:</b><i>KIF18B</i> expression was assessed tissues cells. We additionally evaluated effects on proliferation, migration,...
BACKGROUND Mesenchymal stem cells (MSCs) have emerged as an attractive alternative to modulating immune response after transplantation. Recent studies shown that systemically administered MSCs enter the inflamed intestine. In present study, we propose a strategy improve efficacy of MSC-based cellular therapy for inflammation using Astragaloside and Baicalein enhance cell survival, inhibit apoptosis, modulate inflammatory in vitro. MATERIAL AND METHODS were induced with lipopolysaccharide...
The epithelial-to-mesenchymal transition (EMT) of peritoneal mesothelial cells (PMCs) is a crucial event in the induction fibrosis (PF), which canonical Wnt/β-catenin signaling participates. Smads reported to interact with β-catenin and synergistically regulates EMT. This study was aimed reveal effect Astragalus on EMT PMCs.To obtain role EMT, gene transfer into HMrSV5 cell line rats has been achieved. After treatment, markers pathway-related indicators were detected by western blotting,...
Plasmid size is one of the factors affecting transfection efficacy in most molecular genetic research studies. One effective approach for reducing plasmid to replace relatively large, conventional antibiotic resistance genes with short-size
MDM2 proto‑oncogene, E3 ubiquitin protein ligase (MDM2) is a well‑known oncogene and has been reported to be closely associated with epithelial‑to‑mesenchymal transition (EMT). The present study first demonstrated that the expression levels of were markedly increased in TGF‑β‑induced EMT using quantitative PCR western blotting. In addition, was pathological grade clinical glioma samples by immunohistochemical staining. Furthermore, overexpression promoted glioma, lung cancer breast cell...
Abstract Scutellarin, an active flavone extracted from Erigeron breviscapus , is known to exhibit antitumour activity in many cancers. However, the effects of Scutellarin on osteosarcoma remain unclear. In this study, we found that suppressed cell growth, induced apoptosis and inhibited tumorigenesis. Mechanistically, our data revealed EGR1 was significantly increased under treatment. Increased enhanced tumour‐suppressive cells via transcriptionally downregulating LINC00857 expression....
Duchenne Muscular Dystrophy (DMD) is a recessive form of muscular disorder, resulting from the dystrophin gene mutations in X-chromosome. Application embryonic stem cells or adult has demonstrated therapeutic effects on DMD through both cell-based and non-cell based mechanisms. In this study, we proposed that Myogenic Progenitor Cells Induced Pluripotent Stem (iPSC-MPCs) would be more effective repairing muscle damage caused by dystrophy.Mouse iPSCs were cultured myogenic differentiation...
Glioblastoma multiforme is the most aggressive primary brain cancer in adults. Therefore, it important to investigate mechanisms associated with cell viability and invasion ability of cells glioblastoma multiforme. The opposite strand glial line‑derived neurotrophic factor (GDNF) gene used transcribe cis‑antisense GDNF (GDNFOS) gene, which belongs long noncoding RNAs. current study assessed effects GDNFOS1 overexpression interference on expression, U87 U251 MG cells. Overexpression were...
To explore the effect of Yiqi Huoxue Decoction on metabolomics acute myocardial infarction rats. Left anterior descending coronary artery ligation was used to establish an animal model. The rats were randomly divided into model, perindopril, QishenYiqi Dropping Pill and groups compared with a sham-operation group. Blood metabolite changes detected by nuclear magnetic resonance 7 28 days after operation. Metabolite differences between administration model analyzed. P-values in levels drug...
BACKGROUND Inflammation-related markers including neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte (PLR), monocyte-to-lymphocyte (MLR), systemic immune-inflammation index (SII), inflammation response (SIRI) and prognostic nutritional (PNI) could reflect tumor immune microenvironment predict prognosis of cancers. However, it had not been explored in alpha-fetoprotein (AFP) producing gastric cancer (GC). AIM To determine the predictive value inflammation-related peripheral blood as...