A5075780481- Cytomegalovirus and herpesvirus research
- RNA modifications and cancer
- Hematopoietic Stem Cell Transplantation
- Ferroptosis and cancer prognosis
- Cancer-related molecular mechanisms research
- Environmental Quality and Pollution
- Toxoplasma gondii Research Studies
- Lung Cancer Diagnosis and Treatment
- Traditional Chinese Medicine Analysis
- Epigenetics and DNA Methylation
- Peptidase Inhibition and Analysis
- Cancer-related gene regulation
- Bacteriophages and microbial interactions
- Traditional Chinese Medicine Studies
- Antimicrobial Peptides and Activities
- Innovations in Aquaponics and Hydroponics Systems
- Lung Cancer Research Studies
- Monoclonal and Polyclonal Antibodies Research
- Viral Infectious Diseases and Gene Expression in Insects
- Water Quality Monitoring Technologies
- Cancer, Hypoxia, and Metabolism
- Metabolomics and Mass Spectrometry Studies
- Immunodeficiency and Autoimmune Disorders
- Aquaculture Nutrition and Growth
- Immune Cell Function and Interaction
Beijing University of Chinese Medicine
2007-2025
Hebei University of Chinese Medicine
2024
Xuzhou Medical College
2022-2024
Chongqing Medical University
2020-2024
Chengdu Medical College
2024
The Affiliated Yongchuan Hospital of Chongqing Medical University
2024
First Affiliated Hospital of Xinjiang Medical University
2008-2022
Xinjiang Medical University
2008-2022
Sichuan University
2022
Beijing Fengtai Hospital
2021
Chronic hepatitis B virus (HBV) infection is a serious public health burden, and current therapies cannot achieve satisfactory cure rate. There are high unmet medical needs of novel therapeutic agents with differentiated mechanism action (MOA) from the standard care. RG7834, compound dihydroquinolizinone (DHQ) chemical series, first-in-class highly selective orally bioavailable HBV inhibitor which can reduce both viral antigens DNA action. Here we report discovery RG7834 phenotypic screening...
ABSTRACT Detection of Toxoplasma gondii infection with sensitive and specific methods is a key step in the prevention treatment toxoplasmosis. Among available diagnostic tests, serology commonly used. Although serological tests give satisfactory results, production reliable reagents remains laborious expensive. There therefore real need to acquire effective recombinant antigens for serodiagnosis T. infection. In this study, multiepitope peptide was designed successfully expressed Escherichia...
Huayu Wan (HYW), a traditional Chinese medicine prescription widely used in the clinical treatment of advanced lung cancer, has been clinically proven to effectively inhibit progression pulmonary tumors and improve patients' quality life. However, its specific components potential anti-cancer molecular mechanisms remain unclear. To explore active ingredients HYW predict effective targets pathways against non-small cell cancer (NSCLC) using combination network pharmacology transcriptomics....
Phytophthora cactorum is a devastating pathogen that infects wide range of plants and causes rot disease, which has resulted in great economic losses crop production. Therefore, the rapid practicable detection P. important for disease monitoring forecasting. In this study, we developed lateral flow recombinase polymerase amplification (LF-RPA) assay sensitive visual cactorum. Specific primers were designed based on ras-related protein gene Ypt1; all 10 isolates yielded positive results,...
Colorectal cancer (CRC) is the second leading cause of cancer-related deaths. Tumor angiogenesis plays a critical role in CRC metastasis, and hypoxia, which widely existed tumor mass, drives angiogenesis. Sesamin, phytochemical derived from sesame seeds, has been reported to inhibit cell growth however, sesamin its underlying mechanism have not investigated yet. Here, an vitro tube formation assay vivo were used explore In this study, we found that significantly inhibited hypoxia-stimulated...
Gastric cancer (GC) is a malignant tumor with low survival rate, high recurrence and poor prognosis. With respect to this, pyroptosis type of programmed cell death that can affect the occurrence development tumors. Indeed, long non-coding RNAs (lncRNAs) were broadly applied for purposes early diagnosis, treatment, prognostic analysis in regard cancer. Based on association these three purposes, we developed novel prognosis risk model based pyroptosis-related lncRNAs (PRlncRNAs) GC. The...
Recently, numerous studies have been focused on the relationship between GABA-A receptors and alcohol-induced spatial learning memory deficits. GABA-Aα5, a subunit of receptors, is considered to play an important role in cognitive impairment, however, mechanism remains obscure. In this study, we found that expression GABA-Aα5 increased rats treated with chronic ethanol via histone H3K9 acetylation. Furthermore, epigenetic modification could be inherited by next generations, which eventually...
Background Hedysarum Multijugum Maxim–Curcumae Rhizoma (HMMCR), a well-known herb pair in traditional Chinese medicine (TCM), has been widely used for the treatment of various cancers. However, active components HMMCR and underlying mechanism non-small-cell lung carcinoma (NSCLC) remain unclear. Methods Active ingredients were detected by liquid chromatography electrospray ionization tandem mass spectrometry (LC-ESI-MS/MS). On this basis, potential targets obtained from SwissTargetPrediction...
Antigenic drift is the biggest challenge for mutagenic RNA virus vaccine development. The primary purpose to determine IEMM (immune escape mutation map) of 20 amino acids' replacement reveal rule viral immune escape. To relationship between epitope and escape, we use universal protein tags as a linear model. describe draw acid linkage diagrams, mutations are classified into four categories: IEM mutation), ADERM (antibody-dependent enhancement risk EQM (equivalent IVM (invalid mutation)....
Abstract Hemodynamic alteration with postural change from supine to sitting has been unclear in the young. In cross-sectional study, 686 participants (371 boys and 315 girls, aged 6–18 years) were recruited 4 schools Kaifeng city, central area of China. The active test was performed obtain heart rate (HR) blood pressure (BP) changes children adolescents. change-associated intolerance analyzed. study participants, 95th percentile (P 95 ) values HR BP within 3 min 25 beats/min 18/19 mm Hg,...
To construct a traditional Chinese medicine (TCM) syndrome elements diagnostic scale for diabetic kidney disease (DKD).A total of 492 DKD patients were included in the study. TCM symptoms, signs and tongue manifestation information collected, which constituted items scale. Frequency dominance method was used to screen core items. Cluster analysis factor identify elements. Correlation coefficient regression determine Regression items, threshold established by receiver operating characteristic...
The enhancer of zeste homolog 2 (EZH2) is a methylated modification enzyme Histone H3-Lys 27. high expression EZH2 in cells closely related to the progression, invasion, and metastasis neoplasm. Therefore, this target gradually becoming one research hot spots tumor pathogenesis, inhibitors are expected become new antitumor drugs. This study used series virtual screening technologies calculate affinity between compounds obtained from ZINC15 database protein EZH2, stability ligand-receptor...
Thermal ablation is widely used in the treatment of lung cancer and beneficial for overall survival patients clinic. However, there barely a priority which system should be chosen under different periods tumor progression cancer. The present study investigated modes thermal systems mice with transplanted Lewis carcinoma tumors their various biological effects local regions using untargeted metabolomics. results showed that could significantly suppress growth differentially expressed...