A5103135002- Aortic Disease and Treatment Approaches
- Cancer-related molecular mechanisms research
- Aortic aneurysm repair treatments
- RNA modifications and cancer
- Lipid metabolism and disorders
- Medicinal Plant Pharmacodynamics Research
- Retinal Diseases and Treatments
- Intraocular Surgery and Lenses
- Liver Disease Diagnosis and Treatment
- Cardiac, Anesthesia and Surgical Outcomes
- Circular RNAs in diseases
- Autophagy in Disease and Therapy
- Cancer Cells and Metastasis
- Angiogenesis and VEGF in Cancer
- Renal and related cancers
- Corneal surgery and disorders
- Epigenetics and DNA Methylation
- Hepatitis B Virus Studies
- Ophthalmology and Visual Impairment Studies
- Cardiac Valve Diseases and Treatments
- Intracerebral and Subarachnoid Hemorrhage Research
- Traditional Chinese Medicine Analysis
- MicroRNA in disease regulation
- Heme Oxygenase-1 and Carbon Monoxide
- Infectious Aortic and Vascular Conditions
Heilongjiang University of Chinese Medicine
2025
Southwest Medical University
2025
Xuzhou Medical College
2022-2024
Second Affiliated Hospital of Jilin University
2018-2024
Guangdong Academy of Medical Sciences
2019-2024
Southern Medical University
2024
Guangdong Provincial People's Hospital
2019-2024
Union Hospital
2024
China Medical University
2024
Fujian Medical University
2024
Liver pathological changes are as high 21%-78% in diabetic patients, and treatment options lacking. Liraglutide is a glucagon-like peptide-1 (GLP-1) receptor that widely used the clinic approved to treat obesity diabetes. However, specific protection mechanism needs be clarified. In present study, db/db mice were simulate Type 2 diabetes mellitus (T2DM), they intraperitoneally injected daily with liraglutide (200 μg/kg/d) for 5 weeks. Hepatic function, pathologic changes, oxidative stress,...
Obstructive sleep apnoea (OSA) causes chronic intermittent hypoxia (CIH), which results in mitochondrial dysfunction and generates reactive oxygen species (ROS) the heart. Excessive free iron could accelerate oxidative damage, may be involved this process. Banxia-Houpu decoction (BHD) was reported to improve hypopnoea index OSA patients, but specific mechanism still unclear.To investigate whether BHD reduce CIH-induced heart damage by regulating metabolism function.C57BL/6N mice were...
Colorectal cancer is a malignancy with high incidence and mortality worldwide, ulcerative colitis (UC) strongly associated colorectal cancer. Purple yam, also known as Dioscorea alata, has been reported to be rich in plant polyphenols that have possessed anti-inflammatory, antioxidant, antitumor properties. However, it not clear whether purple yam polyphenol extracts (PYPE) can improve inhibit colitis-related tumorigenesis. Therefore, we used dextran sulfate sodium (DSS)-induced azoxymethane...
Chronic intermittent hypoxia (CIH) could cause neuronal damage, accelerating the progression of dementia. However, safe and effective therapeutic drugs delivery are needed for successful CIH therapy.
Glucocorticoids-induced osteoporosis poses a critical health issue due to its detrimental impact on bone marrow mesenchymal stem cells (BMSCs); Tanshinone IIA (TSA) emerges as promising therapeutic intervention, demonstrating capacity reverse osteogenic differentiation impairment. The aim is determine whether TSA enhances the of BMSCs damaged by dexamethasone (DEX) through ERK1/2 -CREB signaling pathway. were treated with varying concentrations DEX (0.1-30 μM) and (0.04-5 for 18 or 36 h....
The goal of present study is to document our single-center experience with chimney technique for aortic arch diseases.From August 2012 October 2017, 226 patients (mean age 54±12 years; 197 men) diseases underwent thoracic endovascular repair combined stents. stent-grafts were deployed in zone 0 (n=22), 1 (n=13), or 2 (n=191).The technical success rate was 84% (189/226) and immediate type Ia endoleak (ELIa) happened 37 (16%) patients. 30-day mortality morbidity rates 2% (4/226) 4% (8/226),...
Vitiligo is a frequent acquired depigmentation skin disease due to loss of melanocytes. This study sought characterize the expression pattern microRNA (miRNA) in peripheral blood mononuclear cells (PBMCs) non-segmental vitiligo (NSV) patients. We also screened for molecular markers that can be used evaluate clinical stages NSV.The miRNA profile PBMCs four patients with progressive NSV and healthy controls was determined using high-throughput RNA sequencing. The divergently expressed verified...
Abstract Background The predominant immune cells in solid tumors are M2-like tumor-associated macrophages (M2-like TAMs), which significantly impact the promotion of epithelial-mesenchymal transition (EMT) tumors, enhancing stemness and facilitating tumor invasion metastasis. However, contribution TAMs to progression gallbladder cancer (GBC) is partially known. Methods Immunohistochemistry was used evaluate expression stem cell (CSC) markers 24 pairs GBC adjacent noncancerous tissues from...
BACKGROUND Diabetic retinopathy is a primary contributor of visual impairment in adult diabetes mellitus patients. causes breakdown blood retinal barrier (BRB), and leads to diabetic macular edema. Previous studies have demonstrated angiopoietin-like protein 4 (ANGPTL4) as an effective therapeutic target, however, its role maintaining the outer BRB has yet not elucidated. MATERIAL AND METHODS We established vivo rat model with use streptozotocin injections cultured ARPE-19 cells under...
Obstructive sleep apnea (OSA) patients exhibit different degrees of cognitive impairment, which is related to the activation reactive oxygen species (ROS) production by chronic intermittent hypoxia (CIH) and deposition iron in brain. As a central regulator homeostasis, whether hepcidin involved OSA‐induced impairment has not been clarified. In order simulate OSA, we established mouse model reducing percentage inspired O 2 (FiO ) from 21% 5%, 20 times/h for 8 h/day. We found was rising during...
The hepatitis B Virus X (HBx) protein plays a crucial role in the HBV-induced hepatic steatosis. Fatty acid transport 2 (FATP2) is key that involved lipogenesis, and it was found to be highly expressed various metabolic diseases. However, Whether FATP2 factor pathogenesis of HBx-induced steatosis remains unclear. In this study, we up-regulated by HBx vitro vivo participated lipid accumulation. Treatment HBx-expressing cell lines mice with inhibitor (FATP2i) lipofermata ameliorated...
This study aimed to assess the association of postoperative platelet counts with early and late outcomes after thoracic endovascular aortic repair (TEVAR) for type B dissection (TBAD). We retrospectively evaluated 892 patients TBAD who underwent TEVAR from a prospectively maintained database. Postoperative nadir were as continuous variable, categorical variable (thrombocytopenia), which was defined count≤ lowest 10% percentile (108 × 109/l). Multivariable logistic regression analyses...
The present study aimed to investigate the incidence and predictors of post-operative delirium (POD) in patients with complicated type B aortic dissection (TBAD) undergoing TEVAR with/without concomitant procedures assess association POD early follow-up outcomes.A retrospective single-center cross-sectional analysis was conducted using a prospectively maintained database from 2010 2017. Outcomes were postoperative clinical outcomes, survival.A total 517 TBAD enrolled. observed 13.3% (69/517)...
Aims: The monocyte to high-density lipoprotein ratio (MHR), a novel marker of inflammation and cardiovascular events, has recently been found facilitate the diagnosis acute aortic dissection. This study aimed assess association preoperative MHR with in-hospital long-term mortality after thoracic endovascular repair (TEVAR) for type B dissection (TBAD). Methods: We retrospectively evaluated 637 patients TBAD who underwent TEVAR from prospectively maintained database. Multivariable logistic...
Prostate cancer is currently the most common malignancy among men. Given limitations of current conventional anticancer therapies, new high-risk treatments are urgently needed. Previous studies have shown that embryonic stem cells (ESCs) can reverse tumorigenic phenotype tumor cells. However, there still challenges in using human ESCs (hESCs) directly treatment. To facilitate practical application hESCs, we established a co-culture system consisting prostate cell lines and hESCs investigated...
We explored the patterns of long non-coding RNA (lncRNA) expression in peripheral blood mononuclear cells (PBMCs) from patients with non-segmental vitiligo.We used high-throughput sequencing technology to generate sequence data five vitiligo alongside normal healthy individuals, and then performed bioinformatics analyses detect differential lncRNA PBMCs. Gene Ontology (GO) pathway were for functional annotation, quantitative real-time polymerase chain reaction (qRT-PCR) was verify gene...
Abstract Renal cell carcinoma, a leading cause of death in urological malignancies, arises from the nephron. Its characteristics include diversity disease biology, varied clinical behaviors, different prognoses, and diverse responses to systemic therapies. The term ‘organoids’ is used describe structures resembling tissues created through three-dimensional cultivation stem cells vitro. These organoids, when derived tumor tissues, can retain primary tumor, mirror its spatial tissue structure,...