A5102757067- Cancer-related molecular mechanisms research
- Circular RNAs in diseases
- melanin and skin pigmentation
- Kruppel-like factors research
- Immunotherapy and Immune Responses
- Cancer Immunotherapy and Biomarkers
- Melanoma and MAPK Pathways
- Silkworms and Sericulture Research
- Atherosclerosis and Cardiovascular Diseases
Second Affiliated Hospital of Nanchang University
2018-2024
Nanchang University
2018-2024
Third Affiliated Hospital of Sun Yat-sen University
2018
Sun Yat-sen University
2018
The genes COL1A1 and COL1A2 encode the pro-alpha 1 2 chains of type I collagen, respectively, which is one main components skin dermis. We have previously demonstrated that a circular RNA (a class recently identified non-coding RNAs exhibit regulatory potency by sequestering miRNAs like sponge), we termed circCOL3A1-859267, downregulated regulates collagen expression in UVA-exposed human dermal fibroblasts (HDFs). However, precise mechanisms circCOL3A1-859267-mediated UVA-irradiated HDFs...
Vitiligo is a frequent acquired depigmentation skin disease due to loss of melanocytes. This study sought characterize the expression pattern microRNA (miRNA) in peripheral blood mononuclear cells (PBMCs) non-segmental vitiligo (NSV) patients. We also screened for molecular markers that can be used evaluate clinical stages NSV.The miRNA profile PBMCs four patients with progressive NSV and healthy controls was determined using high-throughput RNA sequencing. The divergently expressed verified...
We explored the patterns of long non-coding RNA (lncRNA) expression in peripheral blood mononuclear cells (PBMCs) from patients with non-segmental vitiligo.We used high-throughput sequencing technology to generate sequence data five vitiligo alongside normal healthy individuals, and then performed bioinformatics analyses detect differential lncRNA PBMCs. Gene Ontology (GO) pathway were for functional annotation, quantitative real-time polymerase chain reaction (qRT-PCR) was verify gene...