A5025428862- Skin Protection and Aging
- RNA Interference and Gene Delivery
- Systemic Lupus Erythematosus Research
- MicroRNA in disease regulation
- Gastrointestinal motility and disorders
- Spaceflight effects on biology
- Gastroesophageal reflux and treatments
- Monoclonal and Polyclonal Antibodies Research
- Thermoregulation and physiological responses
- Acute Ischemic Stroke Management
- Helicobacter pylori-related gastroenterology studies
- Advanced Biosensing Techniques and Applications
- Imbalanced Data Classification Techniques
- Eosinophilic Esophagitis
- Advanced X-ray and CT Imaging
- Antioxidant Activity and Oxidative Stress
- Phytochemistry and biological activity of medicinal plants
- Bee Products Chemical Analysis
- Dermatologic Treatments and Research
- Acute Myocardial Infarction Research
- Chemokine receptors and signaling
- Coronary Interventions and Diagnostics
- Occupational Health and Performance
- Eosinophilic Disorders and Syndromes
- Peroxisome Proliferator-Activated Receptors
Witten/Herdecke University
2020-2021
Protagen (Germany)
2013-2017
Siemens (Germany)
2001
Ruhr University Bochum
2001
TU Dortmund University
2001
Cardiac microRNA-132-3p (miR-132) levels are increased in patients with heart failure (HF) and mechanistically drive cardiac remodelling processes. CDR132L, a specific antisense oligonucleotide, is first-in-class miR-132 inhibitor that attenuates even reverses HF preclinical models. The aim of the current clinical Phase 1b study was to assess safety, pharmacokinetics, target engagement, exploratory pharmacodynamic effects CDR132L on standard-of-care therapy for chronic ischaemic randomized,...
Background and Purpose —Besides the delineation of hypoperfused brain tissue, characterization ischemia with respect to severity is major clinical relevance, because degree hypoperfusion most critical factor in determining whether an ischemic lesion becomes infarct or represents viable tissue. CT perfusion imaging yields a set related parameters which might be useful describe hemodynamic status brain. Our objective was determine measurements relative cerebral blood flow (rCBF), volume...
Coriander oil is used as an antimicrobial agent and a natural fragrance. The present study investigated the anti-inflammatory potency of coriander in ultraviolet (UV) erythema test vivo.40 volunteers were enrolled this monocentric,randomized,placebo-controlled double-blind study.Test areas on back irradiated with 1.5 fold minimal dose UV-B. Subsequently, treated under occlusion for 47 hours lipolotion containing 0.5% or 1.0% essential oil. Hydrocortisone (1.0%) betamethasone valerate (0.1%)...
Gastro-oesophageal reflux disease (GERD), functional dyspepsia (FD) and irritable bowel syndrome (IBS) are highly prevalent gastrointestinal conditions with accumulating evidence of overlap in patients. Despite availability a vast body research related to individual disorders, major pharmacological breakthrough treatment the condition is still lacking.To assess sustainability GERD healing whether known beneficial effects proton pump inhibitor on also extend symptoms suggestive FD IBS.A total...
<b><i>Background:</i></b> Skin reaction to spaceflight has not really been studied yet, although the skin a very important barrier function protect body and can contribute more general understanding of physiology. It is proposed here make thorough investigation during long-term spaceflight, using noninvasive techniques. <b><i>Aims:</i></b> The aim present Skin-B study investigate kinetics range possible modifications long-duration spaceflights...
During the COVID-19 pandemic emergency departments have noted a significant decrease in stroke patients. We performed timely analysis of Bavarian telestroke TEMPiS "working diagnosis" database.Twelve hospitals from network were selected. Data collected for January through April years 2017 2020 extracted and analyzed presumed definite ischemic (IS), amongst other disorders. In addition, recommendations intravenous thrombolysis (rtPA) endovascular thrombectomy (EVT) mobility data region...
Background. Reliable predictive factors for therapy outcome may enable treating physicians to counsel their patients more efficiently concerning probability of improvement or time point discontinuation a certain therapy. Methods. This is retrospective analysis 87 with exudative age-related macular degeneration who received three monthly intravitreal ranibizumab injections. Visual acuity before initiation and 4-6 weeks after last injection was compared related the preoperative visualisation...
Background Chronic inflammation is frequently observed on histological analysis of malignant and non-malignant prostate specimens. It a suspected supporting factor for diseases their progression main cause false positive PSA tests in cancer screening. We hypothesized that induces autoantibodies, which may be useful biomarkers. aimed to identify validate associated serum autoantibodies patients evaluate the expression corresponding autoantigens. Methods Radical prostatectomy specimens (N =...
N,N-Dimethylglycine (DMG), being part of the endogenous homocysteine pathway, and its sodium salt (DMG-Na) have been widely used in animal husbandry to increase feed/weight ratio, induce fattening or boost physical performance, were also approved as a safe non-fuel food supplement for humans (Cupp Tracy, 2003Cupp MJ, Tracy TS. Dimethylglycine (N,N-Dimethylglycine). In: Cupp TS, editors. Dietary Supplements: Toxicology Clinical Pharmacology. Totowa, NJ: Humana Press; 2003. p. 149–160.Google...
Immediate reopening of acutely occluded coronary arteries via primary percutaneous intervention (PCI) is the treatment choice to salvage ischemic myocardium in setting ST-segment elevation myocardial infarction (STEMI). However, sudden re-initiation blood flow achieved with PCI can lead a local acute inflammatory response further endothelial and damage.This phenomenon, described as ‘reperfusion injury’, has been recognized for several decades, yet no pharmacologic so far succeeded reducing...
Symptoms suggestive of functional dyspepsia (FD) and irritable bowel syndrome (IBS) frequently overlap with those gastroesophageal reflux disease. Despite the high prevalence symptomatic overlap, underlying etiology remains poorly defined. We assessed correlation relief health-related quality life (HRQoL) healing esophagitis to further derive insights into etiology. 626 patients were enrolled one two treatment groups (classical concept or complete remission concept) investigate differences...
Abstract Background In space, due to fluid shift a 45% decrease in the skin topography parameter volume (mm 3 ) was seen using VisioScan ® camera. Simultaneously, parameters roughness, scaling and wrinkles changed dramatically as well. Thus, present study has objective understand relationship between SELS under extreme conditions their application by addressing scientific‐dermatological questions. Material Methods measurements were performed on volar forearms of six astronauts. The Pearson...
<b><i>Background:</i></b> Sunscreen products aim to help protect the skin against UV radiation and consequently reduce risk of early ageing cancer. However, it is well known that some sunscreen ingredients are not photostable, but this usually refers irradiation with light. Moreover, has be mentioned a relative cumulative erythema effectiveness compliant light source used for in vivo sun protection factor (SPF) testing. Here, simulators equipped xenon arc lamp use...
Today, the sun protection factor (SPF) value of sunscreen products is determined in vivo with a standardized protocol (EN ISO 24444:2010), and measured SPF biological end point visible skin erythema. However, many currently available on market have antiphlogistic ingredients, which may potentially result an overestimated sunscreen.To investigate potential influence ingredients panthenol bisabolol sunscreens vivo.Formulations different concentrations or were tested. As reference, base...
About 50% of the sun's radiation arriving on earth is visible light (VIS). For a long time, its effects human health have not been fully investigated. But recently, influence VIS has gained more attention, especially regarding skin physiology. Studies showed various effects, many them harmful, comparable to UV radiation. As result, there are now few sunscreens commercially available which claim protection against VIS. The question whether necessary still much discussed.The objective this...
The classification of a population by specific trait is major task in medicine, for example when diagnostic setting groups patients with diseases are identified, but also predictive medicine group classified into disease severity classes that might profit from different treatments. When the sizes those subgroups become small, rare diseases, imbalances between more rule than exception and make statistical problematic error rate minority class high. Many observations as belonging to majority...
BACKGROUND : The first skin physiological pilot experiment (SkinA) on a single astronaut showed deterioration of the skin. In follow-up (SkinB) we that parameters improved average. However, it is well known sports have positive effects skin, astronauts prefer special devices, and do with different intensity. aim this study was to analyze activities SkinB find out whether they an influence parameters. METHODS cumulative distance covered treadmill cycle ergometer as repetition arm-related...
Abstract Background Cardiac microRNA-132-3p (miR-132) levels are increased in patients with heart failure (HF) and mechanistically drive cardiac remodelling processes. CDR132L, a specific antisense oligonucleotide, is first-in-class miR-132 inhibitor that attenuates even reverses HF preclinical models. Purpose The aim of the current clinical Phase 1b study was to assess safety, pharmacokinetics, target engagement, exploratory pharmacodynamic effects CDR132L on standard-of-care therapy for...
Cardiac microRNA-132-3p (miR-132) levels are elevated in people suffering with heart failure (HF) and mechanistically drive remodelling processes the heart. Here we present CDR132L, a specific antisense oligonucleotide. It is first-in-class miR-132 inhibitor that attenuates even reverses HF preclinical models. The aim of this clinical Phase 1b study was to assess safety, pharmacokinetics, target engagement, pharmacodynamics CDR132L patients on therapy for chronic ischaemic randomized,...
<h3>Background</h3> Rheumatoid arthritis (RA) is an autoimmune disease typically characterized by chronic inflammation, accumulation of self-reactive B-cells and production autoantibodies which anti–cyclic citrullinated peptide (anti-CCP) antibodies rheumatoid factor (RF) have diagnostic utility. Despite these two well established markers up to 30% RA patients remain sero-negative making early diagnosis more difficult. Although progress has been made characterize risk factors for anti-CCP...
<h3>Background</h3> SLE is a chronic multisystem autoimmune disease with yet unknown etiology. One hallmark of the B cell activation and production various autoantibodies. Differential diagnosis involves ANA screening which may yield also positive results in many connective tissue disorders other diseases, occur normal individuals. More specific subtypes antinuclear antibodies include anti-Smith anti-double stranded DNA (dsDNA) antibodies. However, anti-dsDNA are present just 70% patients...