A5010857579- Milk Quality and Mastitis in Dairy Cows
- Retinal Development and Disorders
- NF-κB Signaling Pathways
- Immune Response and Inflammation
- Hepatocellular Carcinoma Treatment and Prognosis
- Lung Cancer Research Studies
- Cancer-related molecular mechanisms research
- Pancreatic and Hepatic Oncology Research
- Circular RNAs in diseases
- RNA modifications and cancer
- Functional Brain Connectivity Studies
- Antimicrobial Peptides and Activities
- Cancer Cells and Metastasis
- Natural product bioactivities and synthesis
- Gut microbiota and health
- Advanced Neuroimaging Techniques and Applications
- Lung Cancer Diagnosis and Treatment
- Organ Transplantation Techniques and Outcomes
- Cancer Immunotherapy and Biomarkers
- Pancreatitis Pathology and Treatment
- Parvovirus B19 Infection Studies
- Autoimmune and Inflammatory Disorders Research
- Pharmacological Effects of Natural Compounds
- Immune Cell Function and Interaction
- Corneal Surgery and Treatments
First Hospital of Lanzhou University
2018-2025
Lanzhou University
2018-2025
University of South China
2024
Sun Yat-sen University
2017-2024
Peking University People's Hospital
2016-2024
Peking University
2016-2024
Nanchang University
2019-2021
Zhongshan Ophthalmic Center, Sun Yat-sen University
2020
Third Affiliated Hospital of Sun Yat-sen University
2017-2018
Qingdao University
2015-2017
Gastric cancer (GC) is one of the most common cancers in world; however, chemoresistance greatly decreases efficacy therapy gastric cancer. Long noncoding RNAs (IncRNAs) participate a variety biological processes, and we hypothesize that lncRNA HULC regulates multidrug resistance GC treatment.We obtained tissue samples from 42 patients detected expression level plasma tissues via qRT-PCR. The relationship between survival rate was confirmed by Kaplan-Meier analysis. We verified cell lines...
588 Background: High recurrence rate after curative resection significantly compromised the long-term survival of patients with HCC (pts). TACE as adjuvant therapy was proved to improve clinical outcomes for pts high risk factors hepatectomy. However, prognosis reminded unsatisfactory and controversial. Therefore, this study aimed identify efficacy safety anlotinib maintenance treatment following inductional in HCC. The preliminary results had been reported 2024 ASCO GI (Poster 513) update...
All cancers develop from malignant transformation of normal cells, while it is challenging to identify these cells-of-origin since impossible witness the dynamic changes in human cancers. Retinoblastoma (Rb), an intraocular cancer, a typical model for study molecular and cellular mechanisms Although maturing cone precursors (CPs) are proposed as origin Rb, unknow whether other retinal cells also sensitive RB1 inactivation. Here we developed RB1-deficient organoids (ROs) models RB1-/- or...
Thyroid cancer (TC) is the most common endocrine malignancy. Lack of effective early diagnostic tools one clinical obstacles for TC treatment. Thus, enhanced comprehension molecular changes in tumorigenesis urgently needed to develop novel strategies diagnosis and treatment TC. Long non-coding RNAs (lncRNAs) manage fundamental biochemical cellular processes development. One best-described lncRNAs, HOX transcript antisense RNA (HOTAIR), functions as a regulatory molecule wide variety...
Abstract Background Accumulating evidence demonstrates that tRFs (tRNA-derived small RNA fragments) and tiRNAs stress-induced RNA), an emerging category of regulatory molecules derived from transfer RNAs (tRNAs), are dysregulated in various human cancer types play crucial roles. However, their roles mechanisms hepatocellular carcinoma (HCC) liver stem cells (LCSCs) still unknown. Methods The expression glycine tRNA-derived fragment (Gly-tRF) was measured by qRT-PCR. Flow cytometric analysis...
RPE65-associated Leber congenital amaurosis (LCA) is one of highly heterogeneous, early onset, severe retinal dystrophy with at least 130 gene mutation sites identified. Their pathogenicity has not been directly clarified due to lack diseased cells. Here, we generated human induced pluripotent stem cells (hiPSCs) from putative LCA patient carrying two novel RPE65 mutations c.200T>G (p.L67R) and c.430T>C (p.Y144H), named RPE65-hiPSCs, which were confirmed contain the same mutations. The...
The genes COL1A1 and COL1A2 encode the pro-alpha 1 2 chains of type I collagen, respectively, which is one main components skin dermis. We have previously demonstrated that a circular RNA (a class recently identified non-coding RNAs exhibit regulatory potency by sequestering miRNAs like sponge), we termed circCOL3A1-859267, downregulated regulates collagen expression in UVA-exposed human dermal fibroblasts (HDFs). However, precise mechanisms circCOL3A1-859267-mediated UVA-irradiated HDFs...