A5004631039- Chronic Obstructive Pulmonary Disease (COPD) Research
- Respiratory Support and Mechanisms
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Inhalation and Respiratory Drug Delivery
- COVID-19 Clinical Research Studies
- Occupational and environmental lung diseases
- Long-Term Effects of COVID-19
- Atomic and Subatomic Physics Research
- Circular RNAs in diseases
- Mesenchymal stem cell research
- Mitochondrial Function and Pathology
- Heat shock proteins research
- Air Quality and Health Impacts
- Chronic Disease Management Strategies
- Neuroscience of respiration and sleep
- Skin Protection and Aging
- Congenital Diaphragmatic Hernia Studies
- Lung Cancer Diagnosis and Treatment
- Asthma and respiratory diseases
- Sepsis Diagnosis and Treatment
- Respiratory and Cough-Related Research
- Antifungal resistance and susceptibility
- Genomics, phytochemicals, and oxidative stress
- Nursing Diagnosis and Documentation
- Traditional Chinese Medicine Analysis
Second Xiangya Hospital of Central South University
2014-2025
Central South University
2015-2025
Hunan Provincial Center for Disease Control and Prevention
2020-2025
State Key Laboratory of Respiratory Disease
2023
ORCID
2020
University of Pittsburgh
2017-2019
Third Affiliated Hospital of Sun Yat-sen University
2017
Sun Yat-sen University
2017
XinHua Hospital
2012
Hangzhou Red Cross Hospital
2012
The mechanisms of aging that are involved in the development idiopathic pulmonary fibrosis (IPF) still unclear. Although it has been hypothesized proliferation and activation human lung fibroblasts (hLFs) essential IPF, no studies have assessed how this process works an lung. Our goal was to elucidate if there were age-related changes on primary hLFs isolated from IPF lungs compared with age-matched controls. We investigated several hallmarks patients increased cellular senescence higher...
Idiopathic pulmonary fibrosis (IPF) is a chronic lung disease for which age the most important risk factor. Different mechanisms associated with aging, including stem cell dysfunction, have been described to participate in pathophysiology of IPF. We observed an extrapulmonary effect IPF: increase senescence bone marrow-derived mesenchymal cells (B-MSCs).B-MSCs were obtained from vertebral bodies procured IPF patients and age-matched normal controls. Cell was determined by proliferation...
Chronic obstructive pulmonary disease (COPD) is the third leading cause of death worldwide. There no nomogram model available for mortality prediction stable COPD. We intended to develop and validate a predict risk in COPD patients personalised prognostic assessment.
Bone marrow mesenchymal stem cells (BMSCs)-derived exosomes are rich in a variety of active substances, including microRNA (miR) and have shown powerful therapeutic effects to ameliorate cell injury diseases. However, the role BMSCs-derived on chronic obstructive pulmonary disease (COPD) has been poorly studied. In addition, microvascular endothelial (PMVECs) apoptosis contributes onset COPD. Inhibition PMVECs can reverse COPD changes. Therefore, aim this study was explore investigate...
Background Chronic Obstructive Pulmonary Disease (COPD) is a heterogeneous condition with different risk factors, including family history. This study aimed to explore association between history of chronic airway disease and features outcomes COPD.
Pneumoconiosis may play an important role in the development of chronic obstructive pulmonary disease (COPD), and complication COPD impose a heavy burden illness. The study was conducted Hunan Province China from December 1, 2015, to 2016. Consecutive underground male pneumoconiosis patients employed for at least 1 year were recruited Occupational Disease Prevention Institute. Patient information, respiratory symptoms clinical data collected using structured questionnaire. diagnosis assessed...
Background: The chronic obstructive pulmonary disease (COPD) Assessment Test (CAT) questionnaire is a short patient-completed questionnaire, which used to assess the health status of patients with stable COPD. However, whether it good tool evaluate response treatment in acute exacerbation COPD (AECOPD) has been less studied. Methods: were assessed at two visits, admission and on seventh day. Anthropometric variables collected admission. CAT lung function measured twice above time points. At...
Mesenchymal stem cells (MSC) have been shown to ameliorate the deleterious effects of bleomycin in murine models. However, mechanism responsible for protection from pulmonary fibrosis by cell therapy is still poorly understood, especially terms endoplasmic reticulum (ER) stress. We hypothesized that during bleomycin-induced lung injury, markers ER stress, specifically activation unfolded protein response (UPR), increase resembling kinetics collagen deposition described model. aimed elucidate...
Purpose: This real-world study evaluated the effectiveness of different inhalation therapies in patients with symptomatic chronic obstructive pulmonary disease (COPD) China and also explored relevant factors that influence therapy. Patients Methods: We conducted a multicenter prospective longitudinal was carried out 12 hospitals from December 2016 to June 2021. A face-to-face interview collect data. Baseline data were collected at first visit. Minimum clinically important difference (MCID)...
<b><i>Background:</i></b> Long noncoding RNA (lncRNA) are differentially expressed across stages of differentiation and development, but the role lncRNA in human skin photoaging mechanisms remains poorly understood. <b><i>Objective:</i></b> This study aimed to determine expression changes dermal fibroblasts (HDF) induced by repeated UVA irradiation explore correlations between prognosis. <b><i>Methods:</i></b> In UVA-HDF...
Abstract Background As it is less known about the prevalence and characteristics of pain in patients with interstitial lung disease (ILD), this paper aims at determining ILD. Methods Subjects ILD health controls matched ages genders completed Short Form McGill Pain Questionnaire (SF-MPQ) part Brief Inventory (BPI) to elicit pain. The were also assessed through Pulmonary Function Test, Six Minutes Walking Test (6MWT), modified Medical Research Council Dyspnea Scale (mMRC) for state illness...
Oxygen therapy (OT) is the most widely used supportive regime in patients with hypoxemic acute respiratory failure (ARF) due to severe syndrome coronavirus (SARS-CoV-2) infection. The aim of this study was identify effect noninvasive ventilation support on disease 2019 (COVID-19) and risk factors for invasive mechanical (IMV).We retrospectively analyzed confirmed COVID-19 subjects from nine hospitals outside Wuhan. All hospitalized who tested positive by real-time polymerase chain reaction...
Since most internal medicine nurses work with chronic obstructive pulmonary disease (COPD) patients daily, their ability to meet the needs of COPD is an important issue. Our study aimed assess COPD-related knowledge in nurses.A descriptive cross-sectional including 175 participants was conducted investigate levels among a large top-ranked tertiary hospital China. The Bristol Knowledge Questionnaire (BCKQ) used test participants.Overall BCKQ score for all this 35.76 ± 5.49. In comparison...
Background Adenosine triphosphate (ATP) plays an important role in the cochlea. However, source of ATP and mechanism by which it is released remain unclear. This study investigates presence release vitro cultured marginal cells isolated from stria vascularis cochlea neonatal rats. Methods Sprague-Dawley rats aged 1–3 days old were used for isolation, culture, purification cells. Cultured verified flow cytometry. Vesicles containing these identified fluorescence staining. The bioluminescence...
Prohibitin has been identified to play roles in cell survival and apoptosis. Here, this study aimed clarify the role of prohibitin cigarette smoke extract (CSE)-induced endothelial apoptosis.The protein level was assessed by Western blot lung tissues from emphysema control mice. CSE-induced human pulmonary microvascular cells (hPMECs) were applied mimic smoke-related apoptosis vitro. overexpressed hPMECs with or without CSE. Mitochondrial function analyzed JC-1 staining ATP assay kits....
INTRODUCTION Cigarette smoking is one of the most important causes COPD and could induce apoptosis pulmonary microvascular endothelial cells (PMVECs).The conditional knockout LRG1 from reduced emphysema in mice.However, mechanism deletion rescued by cigarette smoke (CS) induced remains unclear.This research aimed to demonstrate whether promotes PMVECs through KLK10 COPD.METHODS Nineteen patients were divided into three groups: control non-COPD (n=7), smoker (n=5).The mouse model defined as...
OSA can cause cognitive impairment (CI). The aim of this study was to investigate whether miR-20a-5p in exosomes derived from bEnd3 cells with IH mediates intercellular crosstalk and induces CI through hippocampal neuronal cell pyroptosis. BEnd3-derived were isolated the normal oxygen control group (NC-EXOS) (IH-EXOS). In vitro, cocultured HT22 cells. Meanwhile, vivo, injected into mice via caudal vein. spatial memory ability tested by MWM method evaluate effect on function mice. Adults...
Background Cough is a common symptom in patients with chronic obstructive pulmonary disease (COPD). Patients cough may exhibit various clinical characteristics and experience varying outcomes based on inhaled therapies they receive.
Background: The morning is the most troublesome time of day for patients with chronic obstructive pulmonary disease (COPD). However, association symptoms and COPD exacerbations in longitudinal follow-up has not been studied. In this study, we mainly aimed to investigate relationship between over a one-year period. And secondary aim was an investigation baseline clinical features. Patients Methods: Ninety-two stable provided information. Morning were assessed Chinese version Chronic...
Pneumoconiosis has high prevalence of chronic obstructive pulmonary disease (COPD), respiratory morbidity, and mortality.The aim the present study was to examine patient characteristics adherence inhaled therapy among pneumoconiosis with COPD in a real-world clinical setting.A cohort patients prescript at least one type long-acting drug followed for 2 years. Demographic COPD-related were collected baseline.In baseline, after adjusting age, dust exposure duration positively correlated number...