A5100639349- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Immune Cell Function and Interaction
- Arsenic contamination and mitigation
- Ferroptosis and cancer prognosis
- Gastric Cancer Management and Outcomes
- Circular RNAs in diseases
- Cancer Immunotherapy and Biomarkers
- Cancer Mechanisms and Therapy
- Genomics and Phylogenetic Studies
- Epigenetics and DNA Methylation
- Cancer-related gene regulation
- Pancreatic function and diabetes
- Gastrointestinal Tumor Research and Treatment
- Heavy metals in environment
- Plant Molecular Biology Research
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Chromium effects and bioremediation
- Metabolism, Diabetes, and Cancer
- Ubiquitin and proteasome pathways
- FOXO transcription factor regulation
- Chromosomal and Genetic Variations
- Immune cells in cancer
Peking University
2016-2025
Peking University Cancer Hospital
2016-2025
Beijing Forestry University
2016-2025
Taizhou University
2025
Zhengzhou University
2023-2024
Shenzhen Institutes of Advanced Technology
2024
Second Xiangya Hospital of Central South University
2020-2024
Central South University
2020-2024
Taizhou People's Hospital
2015-2024
Nantong University
2015-2024
Exosomes are membranous vesicles actively secreted by almost all cells and they deliver certain intracellular molecules, including nucleic acids, proteins, lipids, to target cells. They also considered be good carriers for drug delivery due their biocompatibility, high permeability, low immunogenicity, toxicity. from immune were reported have immunomodulatory activities. Herein we evaluated the application of exosomes derived expanded natural killer (eNK-EXO) treatment ovarian cancer (OC)....
Abstract Immune checkpoint blockade (ICB) offers a new opportunity for treatment gastric cancer (G.C.). Understanding the upstream regulation of immune checkpoints is crucial to further improve efficacy ICB therapy. Herein, using CRISPR-Cas9-based genome-wide screening, we identified TRIM28 as one most significant regulators PD-L1, protein, in G.C. cells. Mechanistically, directly binds and stabilizes PD-L1 by inhibiting ubiquitination promoting SUMOylation. Furthermore, facilitates K63...
Although immune checkpoint blockade have demonstrated promising results, their effects on gastric cancer (GC) are under investigation. Understanding the clinical significance of PD1 and its ligands' expression, together with T cell infiltration might provide clues for biomarkers screening in GC immunotherapy. Immunohistochemistry were performed a tissue microarray including 1,014 specimens using PD1, PDL1 PDL2 antibodies. markers CD3 CD8 also stained quantified by automated image analysis....
Abstract Impaired osteoblast function is involved in osteoporosis, and microRNA (miRNA) dysregulation may cause abnormal osteogenic activity. However, the influence of miRNA on activity underlying mechanisms remain elusive. In this study, miR‐103‐3p was found to be negatively correlated with bone formation specimens from elderly women fractures ovariectomized (OVX) mice. Additionally, directly targeted Mettl14 inhibit activity, METTL14‐dependent N 6 ‐methyladenosine (m A) methylation...
The combination of immune checkpoint blockade and chemotherapy has revolutionized the treatment advanced gastric cancer (GC). It is crucial to unravel chemotherapy-induced tumor microenvironment (TME) modulation identify which immunotherapy would improve antitumor effect.
Islet 1 (ISL1), a LIM-homeodomain transcription factor is essential for promoting pancreatic islets proliferation and maintaining endocrine cells survival in embryonic postnatal islets. However, how ISL1 exerts the role adult is, to date, not clear.Our results show that expression was up-regulated at mRNA level both cultured undergoing glucose oxidase stimulation as well type 2 diabetes mouse models. The knockdown of increased apoptosis HIT-T15 islet cells. Using primary cell models, we...
Abstract H-ferritin (HFn) nanocarrier is emerging as a promising theranostic platform for tumor diagnosis and therapy, which can specifically target cells via binding transferrin receptor 1 (TfR1). This led us to investigate the therapeutic function of TfR1 in GC. The clinical significance was assessed 178 GC tissues by using magneto-HFn nanoparticle-based immunohistochemistry method. effects doxorubicin-loaded HFn nanocarriers (HFn-Dox) were evaluated on TfR1-positive patient-derived...
Ovarian cancer is a life-threatening disease with high mortality rate in women. Our previous work presented that long non-coding RNA (lncRNA) activated by transforming growth factor beta (TGF-β) (lncRNA ATB) played role of oncogene ovarian cancer. However, whether exosomal lncRNA ATB from cells could regulate the tumorigenesis remains unclear.RT-qPCR assay was performed to evaluate level (SKOV3 and A2780). In addition, cells-secreted exosomes were collected ultracentrifugation. CCK8 detect...
Abstract Background Chimeric antigen receptor natural killer (CAR-NK) cells represent a promising advancement in CAR cell therapy, addressing limitations observed CAR-T therapy. However, our prior study revealed challenges CAR-NK targeting CD19 antigens, as they failed to eliminate + Raji NSG tumor-bearing mice, noting down-regulation or loss of expression some cells. In response, this aims enhance efficacy and mitigate the risk tumor recurrence due target escape by developing CD20...
In the past few decades, field of tissue engineering combined with rapid prototyping (RP) techniques has been successful in creating biological substitutes that mimic tissues. Its applications regenerative medicine have drawn efforts research from various scientific fields, diagnostics, and clinical translation to therapies. While some areas therapeutics are well developed, such as skin replacement, many others cartilage repair can still greatly benefit RP due low success and/or inefficiency...
The major methods are used to fix or stabilize the central airways and bronchi with either anterior suspension and/or posterior fixation for severe tracheomalacia (TM). Many support biomaterials, like mesh sternal plate, can be in surgery. But there no specialized biomaterials TM which must casually fabricated by doctors operation. Three dimensional printing (3DP) has currently untapped potential provide custom, protean devices challenging life-threatening disease processes. After meticulous...
We recently reported that miR-1 was one of the most significantly downregulated microRNAs in gastric cancer (GC) patients from The Cancer Genome Atlas microRNA sequencing data. Here we aim to elucidate role carcinogenesis. measured expression human GC cell lines and 90 paired primary samples, analyzed association its status with clinicopathological features. effect on cells evaluated by proliferation migration assay. To identify target genes miR-1, bioinformatic analysis protein array were...
Summary Small signalling peptides, generated from larger protein precursors, are important components to orchestrate various plant processes such as development and immune responses. However, small peptides involved in immunity remain largely unknown. Here, we developed a pipeline using transcriptomics‐ proteomics‐based screening identify putative precursors of peptides: secreted proteins ( SSP s) rice, induced by rice blast fungus Magnaporthe oryzae its elicitor, chitin. We identified 236 s...
Abstract Fetal cytotrophoblast invasion of maternal decidual vasculature is necessary to normal pregnancy. In preeclampsia, there shallow and abnormal remodeling the uterine that lead significant perinatal morbidity mortality. The placental basement membrane (BM) proteins (e.g., laminin collagen) has been implicated in development placenta while level significantly lower preeclampsia. However, are very limited studies, if any, on effect extracellular matrix (ECM) microenvironment...
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B) has been studied to be involved in the development and progression of several human malignancies.However, little is unveiled regarding complex mechanisms TNFRSF11B gastric cancer (GC).The clinical significance was assessed 70 160 GC tissues using immunohistochemistry method gene microarray analysis, respectively.The biological function vitro vivo assays.Immunofluorescence assay used evaluate expression β-catenin nucleus.The...