A5102924566- CAR-T cell therapy research
- Viral gastroenteritis research and epidemiology
- Immune Cell Function and Interaction
- Immunotherapy and Immune Responses
- Virus-based gene therapy research
- Cancer Cells and Metastasis
- Neurogenesis and neuroplasticity mechanisms
- Alzheimer's disease research and treatments
- Extracellular vesicles in disease
- Immune cells in cancer
- Reproductive System and Pregnancy
- FOXO transcription factor regulation
- Cellular Mechanics and Interactions
- Cancer Immunotherapy and Biomarkers
- Luminescence and Fluorescent Materials
- RNA Interference and Gene Delivery
- Digestive system and related health
- T-cell and B-cell Immunology
- Cholesterol and Lipid Metabolism
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Peroxisome Proliferator-Activated Receptors
- Angiogenesis and VEGF in Cancer
- Educational Robotics and Engineering
- MicroRNA in disease regulation
- Bacteriophages and microbial interactions
Guiyang Medical University
2017-2024
Guiyang University
2019
Exosomes are membranous vesicles actively secreted by almost all cells and they deliver certain intracellular molecules, including nucleic acids, proteins, lipids, to target cells. They also considered be good carriers for drug delivery due their biocompatibility, high permeability, low immunogenicity, toxicity. from immune were reported have immunomodulatory activities. Herein we evaluated the application of exosomes derived expanded natural killer (eNK-EXO) treatment ovarian cancer (OC)....
Abstract Among breast cancer patients, metastases are the leading cause of death. Despite decades effort, little progress has been made to improve treatment metastases, especially triple‐negative (TNBC). The extracellular matrix plays an important role in tumour growth and metastasis by causing its deposition, remodelling, signalling. As we know, process fibrosis results excessive amounts being deposited within cells. So, it will be interesting study if use anti‐fibrotic drugs combination...
The immunosuppressive tumor microenvironment (TME) is the main reason for failure of many immunotherapies that directly stimulate anti-tumor immune response. Anti-CTLA-4 antibody may reduce effector regulatory T (Treg) cell numbers and their suppressive activity in TME. We have previously reported combination anti-CTLA-4 with MUC1 mRNA nanovaccine mutually enhance each single treatment. But enhancement mechanism therapeutic efficacy plus monoclonal (mAb) unknown. In this study, CTL induced...
Q[7] polymer based vesicles, as a PS loading vehicle, demonstrated highly enhanced photosensitization and efficient anticancer effects <italic>via</italic> entering the nuclei of cancer cells.
Abstract Background Cetuximab has been approved for use first-line treatment of patients with wild-type KRAS metastatic colorectal cancer (CRC). However, cetuximab shown limited efficacy as a CRC monotherapy. In addition, natural killer (NK) cell function is known to be severely attenuated in patients. The goal this study was develop new strategy enhance antibody-dependent cell-mediated cytotoxicity (ADCC) mediated by NK cells, combination against cells. Methods Ex vivo expanded cells were...
Oncolytic viruses (OV) have recently emerged as a promising therapeutic modality in cancer treatment. OV selectively infect and kill tumor cells, while sparing untransformed cells. The direct cytotoxic effects combined with the capacity to trigger an immune response make appealing combination partner burgeoning field of immunotherapy. One leading candidates is double-stranded RNA virus reovirus. In order improve oncolytic activity reovirus allow for systemic administration despite prevalence...
Cancer stem cells (CSCs) account for tumor self‐renewal and heterogeneity. Oxidative‐nitrosative stress (ONS) is an independent etiologic factor throughout tumorigenesis. Emerging evidences indicated that the interaction of ONS with CSCs contributes to progression resistance chemoradiotherapy. Cytoglobin (Cygb) a member human hexacoordinate hemoglobin family acts as dynamic mediator redox homeostasis. We observed Cygb significantly deregulated in hepatocellular carcinoma (HCC) tissue its...
Exosomes are lipid bilayer-enclosed vesicles, actively secreted by cells, containing proteins, lipids, nucleic acids, and other substances with multiple biological functions after entering target cells. derived from NK cells have been shown to certain anti-tumor effects potential applications as chemotherapy drug carriers. These developments resulted in high demand for exosomes. Although there has large-scale industrial preparation of exosomes, they only generally engineered such HEK 293T....
To construct type Ⅰ collagen gels with different stiffness and to investigate the effects of three-dimensional (3D) culture environments on morphology, free migration ability, cell killing function natural killer (NK) cells.
Colorectal cancer (CRC) is currently the fourth most common cause of cancer-associated deaths. Treatment with cetuximab, a chimeric immunoglobulin G1 (IgG1) monoclonal antibody targeting epidermal growth factor receptor (EGFR), has shown limited efficacy as CRC monotherapy. In addition, natural killer (NK) cell function known to be severely attenuated in patients. Here, w e describe viable combination strategy enhance NK cytotoxicity while also improving effects cetuxim ab -mediated...