A5101610801- MicroRNA in disease regulation
- Virus-based gene therapy research
- Chronic Kidney Disease and Diabetes
- RNA Interference and Gene Delivery
- Extracellular vesicles in disease
- Renal and related cancers
- Hearing, Cochlea, Tinnitus, Genetics
- Cancer-related molecular mechanisms research
- Cancer, Lipids, and Metabolism
- Connective tissue disorders research
- TGF-β signaling in diseases
- Estrogen and related hormone effects
- Viral Infectious Diseases and Gene Expression in Insects
- CAR-T cell therapy research
- Liver Disease Diagnosis and Treatment
- Connective Tissue Growth Factor Research
- Aquaculture disease management and microbiota
- Osteoarthritis Treatment and Mechanisms
- Nanopore and Nanochannel Transport Studies
- Kruppel-like factors research
- 14-3-3 protein interactions
- NF-κB Signaling Pathways
- Retinoids in leukemia and cellular processes
- Metabolomics and Mass Spectrometry Studies
- Immune cells in cancer
Sir Run Run Shaw Hospital
2023-2025
Zhejiang University
2023-2025
Sichuan University
2025
West China Hospital of Sichuan University
2025
Southwest Jiaotong University
2025
Shenyang Pharmaceutical University
2022-2024
Kunming University of Science and Technology
2023
Affiliated Hospital of Guizhou Medical University
2021-2023
Guiyang Medical University
2021-2023
Maternal and Child Health Hospital of Sichuan Province
2023
Idiopathic pulmonary fibrosis (IPF) is a progressive disease that leads to interstitial inflammation, lung damage, and eventually life-threatening complications. Among various pathologic factors, Smad4 pivotal molecule involved in the progression exacerbation of IPF. It mediates nuclear transfer Smad2/Smad3 complexes initiates transcription fibrosis-promoting genes. Thus, inhibition expression fibroblasts by small interfering RNAs (siRNAs) might be promising therapeutic strategy for Herein,...
Postmenopausal osteoporosis (PMOP) is a chronic systemic bone metabolism disorder. Promotion in the patterns of human marrow mesenchymal stem cells (hBMSCs) differentiation towards osteoblasts contributes to alleviating osteoporosis. Aucubin, natural compound isolated from well-known herbal medicine Eucommia, was previously shown possess various pharmacological effects. However, its effects on hBMSCs PMOP patients are unknown. The aim this present research investigate impact and underlying...
Bio-inspired coral-derived scaffolds have been adopted for bone regeneration. However, these confront challenges such as the limited osteoinductive properties, environmental concerns, and ambiguous calcification mechanisms in coral proteins. In this study, role of recombinant protein galaxin promoting osteogenesis is investigated. The observations reveal that regulates mitochondrial metabolism mouse pre-osteoblasts by interacting with β subunit ATP synthase. This ultimately promotes...
Abstract Osteoporosis is characterized by an imbalance between osteoblasts and osteoclasts coupling excessive oxidative stress in the bone microenvironment that impairs defect healing increases risk of non‐union. In this study, injectable gypsogenin (GN)‐based organic–inorganic composite hydrogel (CCT/nHA@GN) developed to treat osteoporotic defects. The made grafting sodium citrate (SC) nano‐hydroxyapatite (nHA)/GN nanoparticles onto carboxymethylated chitosan (CMCS). GN a natural...
Chronic kidney disease (CKD) is characterized by high morbidity and mortality difficult to cure. Renal interstitial fibrosis (RIF) a major determinant of, commonly occurs within, CKD progression. Epithelial mesenchymal transition (EMT) has been identified as crucial process in triggering renal (RIF). Interleukin-like EMT inducer (ILEI) an important promotor of EMT; this study aims elucidate the mechanisms involved.Male C57BL6/J mouse were randomly divided into 6 groups: sham (n = 10), with...
Bone marrow-derived mesenchymal stem cells (BMSCs) can be obtained by minimally invasive means and would a favourable source for cell-based cartilage regeneration. However, controlling the differentiation of BMSCs towards desired chondrogenic pathway has been challenge hampering their application. The major aim present study was to determine if conditioned medium collected from cultured auricular chondrocytes could promote BMSCs. Auricular were isolated grown in BMSC standard culture (SM)...
Histone H2B protein is not only structurally important for chromosomal DNA packaging but also involved in the regulation of gene expression, including immune response plants against pathogens. In this study, we show that potato virus X (PVX) infection resulted reduced expression at both mRNA and level
Thyroid hormones (T) and estrogens (E) are nuclear receptor ligands with at least two molecular mechanisms of action: ( i ) relatively slow genomic effects, such as the regulation transcription by cognate T receptors (TR) E (ER); ii rapid nongenomic kinase activation calcium release initiated membrane putative receptors. Genomic effects were thought to be disparate independent. However, in a previous study using two-pulse paradigm neuroblastoma cells, we showed that acting could potentiate...
A short period of overfeeding can lead to severe hepatic steatosis in the goose, which is physiological, suggesting that geese, as a descendent migrating ancestor, may have evolutionally developed unique mechanism operates contrast underlying pathological fatty liver humans or other mammals. In this study, we report suppression miR29c and upregulation its target genes goose vs. normal could be part contributes regulation energy homeostasis cell growth.Our data showed expression was...
Renal interstitial fibrosis is the most common process by which chronic kidney diseases progress to end‐stage renal failure. Epithelial‐to‐mesenchymal transitions (EMTs) play a crucial role in progression of fibrosis. A newly identified cytokine, interleukin‐like EMT inducer (ILEI), has been linked some diseases. However, effects ILEI on tubular have not yet well established. Here, we characterize expression and describe mechanism transforming growth factor beta 1 (TGF‐β1)–induced EMT. The...
MicroRNA-122 (miR-122), a completely conserved, liver-specific miRNA in vertebrates, is essential for the maintenance of liver homeostasis. This 22-nucleotide-length RNA regulates diverse functions such as cholesterol, glucose, and lipid metabolism well iron homeostasis infection hepatitis C virus (HCV). Landes goose, which has good, fatty liver, important significance us studying miR-122 function goose liver. In current study, we identified its expression pattern target genes. We found that...
Meeting abstracts Oncolytic virotherapy is safe and clinically active in solid tumors, however its efficacy hematologic malignancies as well combination with checkpoint inhibitors radiation unexplored. To simulate advanced lymphoma, A20 cells were injected subcutaneously on
Exosomes are lipid bilayer-enclosed vesicles, actively secreted by cells, containing proteins, lipids, nucleic acids, and other substances with multiple biological functions after entering target cells. derived from NK cells have been shown to certain anti-tumor effects potential applications as chemotherapy drug carriers. These developments resulted in high demand for exosomes. Although there has large-scale industrial preparation of exosomes, they only generally engineered such HEK 293T....
The thymus is a lobulated unique lymphoid immune organ that plays critical role in the selection, development, proliferation, and differentiation of T cells. developing chickens undergoes continued morphological alterations; however, biomolecular transcriptional dynamics postnatal avian species not clear yet. Therefore, thymuses from at different stages development (at weeks 0, 1, 5, 9, 18, 27) were used present study. RNA-seq method was to study gene expression patterns. On average,...