Lei Cui

ORCID: 0000-0003-2394-7451
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About
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Research Areas
  • Gut microbiota and health
  • Probiotics and Fermented Foods
  • Aquaculture disease management and microbiota
  • Parkinson's Disease Mechanisms and Treatments
  • Fish Biology and Ecology Studies
  • Animal Nutrition and Physiology
  • Immune Response and Inflammation
  • Genetics and Neurodevelopmental Disorders
  • Invertebrate Immune Response Mechanisms
  • Reproductive biology and impacts on aquatic species
  • Trace Elements in Health
  • Epigenetics and DNA Methylation
  • Clostridium difficile and Clostridium perfringens research
  • Protein Hydrolysis and Bioactive Peptides
  • Selenium in Biological Systems
  • Iron Metabolism and Disorders
  • Rabbits: Nutrition, Reproduction, Health
  • Biochemical effects in animals
  • Bacterial biofilms and quorum sensing
  • Aquaculture Nutrition and Growth
  • MicroRNA in disease regulation
  • Medicinal Plant Pharmacodynamics Research
  • Autism Spectrum Disorder Research
  • Neurological disorders and treatments
  • Cell death mechanisms and regulation

Ningbo University
2021-2024

Wenzhou Medical University
2019-2023

Shanghai Academy of Agricultural Sciences
2023

Huazhong Agricultural University
2013-2022

Second Affiliated Hospital & Yuying Children's Hospital of Wenzhou Medical University
2020

Intestinal inflammation is prevalent in chicken, which results decreased growth performance and considerable economic losses. Accumulated findings established the close relationship between gut microbiota chicken performance. However, whether impacts by lessening intestinal remains elusive.Seven-weeks-old male female chickens with highest or lowest body weights were significantly different breast leg muscle indices average cross-sectional area of cells. 16S rRNA gene sequencing indicated...

10.1186/s40168-022-01299-8 article EN cc-by Microbiome 2022-07-15

Background: Alzheimer's disease (AD) and Parkinson's (PD) are two major neurodegenerative diseases worldwide. Demographic aging is in rapid progress China. Up-to-date estimates of AD PD prevalence have not been provided. Methods: Studies that reported the China were identified via a systematic database search from 1985 to 2018. Meta-analysis, local polynomial regression autoregressive integrated moving average model used for analyses. Results: A total 99 studies included study with...

10.3389/fnagi.2020.603854 article EN cc-by Frontiers in Aging Neuroscience 2020-12-21

Protein hydrolysates and peptides in fermented dairy products exhibit antioxidant activities. This study aimed to evaluate the properties of casein whey protein derived from three lactic acid bacteria. The assessment involved observation Reactive oxygen species (ROS), Malondialdehyde (MDA) content, Superoxide dismutase (SOD), Catalase (CAT), cell morphology chromatin H2O2 induced HepG2 model. Casein hydrolyzed by Lactobacillus reuteri exhibited higher activity. ROS content decreased 44.7 %,...

10.1016/j.jff.2024.106221 article EN cc-by-nc Journal of Functional Foods 2024-05-07

Exploring the composition and structure of faecal microbial community improves understanding role gut microbiota in gastrointestinal function egg-laying performance hens. Therefore, detection hen–microbial interactions can explore a new breeding marker for selection egg production due to important microbiome host's metabolism health. Recently, has been recognised as regulator host performance, which led investigations productive effects changes various animals. In present study, metagenomics...

10.1017/s1751731119002428 article EN cc-by-nc-nd animal 2019-10-17

Summary It has been established that gut microbiota influences chicken growth performance and fat metabolism. However, whether affects by regulating metabolism remains unclear. Therefore, seven‐week‐old chickens with high or low body weight were used in the present study. There significant differences weight, breast leg muscle indices, cross‐sectional area of cells, suggesting different performance. The relative abundance caecal contents at genus level was compared 16S rRNA gene sequencing....

10.1111/1751-7915.13841 article EN Microbial Biotechnology 2021-07-15

Viral diseases caused by new outbreaks of viral infections pose a serious threat to human health. Wild brown rats (Rattus norvegicus), considered one the world's largest and most widely distributed rodents, are host various zoonotic pathogens. To further understand composition virus community in wild explore types potentially pathogenic viruses, metagenomics was conducted investigate blood, feces, tissues captured from Zhenjiang, China. Results indicated that different samples showed...

10.1016/j.heliyon.2023.e17222 article EN cc-by Heliyon 2023-06-01

More and more people are aware of the importance intestinal flora to human health, interested in regulation its interaction with host. The survival status probiotics gastrointestinal environment microbial interactions between lactic acid bacteria have also received considerable attention. In this study, tolerance, adhesion ability, biofilm formation Lactobacillus strain coculture system were explored through real-time fluorescence-based quantitative PCR, UPLC-MS/MS metabolic profiling...

10.1128/spectrum.00832-21 article EN Microbiology Spectrum 2022-03-03

MicroRNAs (miRNAs) are small RNA molecules that play key roles in regulation of various biological processes. In order to better understand the significance miRNAs context Aeromonas hydrophila infection Megalobrama amblycephala, libraries obtained from fish liver at 0 (non-infection), 4, and 24 h post (poi) were sequenced using Illumina deep sequencing technology. A total 11,244,207, 9,212,958, 7,939,157 clean reads these three libraries, respectively. Bioinformatics analysis identified 171...

10.3390/ijms17121972 article EN International Journal of Molecular Sciences 2016-11-25

CLEC16A is a membrane-associated endosomal protein implicated in regulating autophagy and antigen presentation. Its genetic variants are broadly associated with multiple autoimmune diseases. Parkinson's disease (PD), which undergoes disruption neuroinflammation, has been clinically observed, for an extensive amount of time, to be In this study, we aimed understand whether the pleiotropically modulate PD risk. Five such variants, including rs6498169, rs12708716, rs12917716, rs7200786,...

10.3389/fgene.2022.856493 article EN cc-by Frontiers in Genetics 2022-03-30

ABSTRACT Parkinson's disease (PD) is associated with α-synuclein-based Lewy body pathology, which has been difficult to observe in conventional two-dimensional (2D) cell culture and even animal models. We herein aimed develop a three-dimensional (3D) cellular model of PD recapitulate the α-synuclein pathologies. All-trans-retinoic acid-differentiated human SH-SY5Y cells Matrigel were optimized for 3D construction. The cultured displayed higher tyrosine hydroxylase expression than 2D improved...

10.1242/dmm.049125 article EN cc-by Disease Models & Mechanisms 2022-01-13

Increasing knowledge of probiotics has shown that co-cultures can achieve better fermentation and beneficial effects, adding LAB to fermented milk fat products increase the production polyunsaturated fatty acids. In this study, acid profiles by L. reuteri DMSZ 8533, plantarum A3, acidophilus CICC 6074 were investigated, strain difference on is also confirmed. The results found A3 with a mixed starter ratio 1 : 2 could promote hydrolysis lipase produce more Furthermore, complex hydrolyzed...

10.1039/d1fo03553c article EN Food & Function 2022-01-01

// Abdur Rahman Ansari 1,2 , Ning-Ya Li 1 Zhi-Jian Sun Hai-Bo Huang Xing Zhao Lei Cui Ya-Fang Hu Ju-Ming Zhong 1,3 Niel A. Karrow 4 and Hua-Zhen Liu Department of Basic Veterinary Medicine, College Animal Science Huazhong Agricultural University, Wuhan, Hubei, China 2 Sciences, Section Anatomy Histology, Sciences (CVAS) Jhang, University (UVAS), Lahore, Pakistan 3 Anatomy, Physiology Pharmacology, Auburn Auburn, USA Biosciences, Guelph, Ontario, Canada Correspondence to: Liu, email: Keywords...

10.18632/oncotarget.19964 article EN Oncotarget 2017-08-05
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