A5100395690- Pain Mechanisms and Treatments
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- Ion channel regulation and function
- RNA modifications and cancer
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Bladder and Urothelial Cancer Treatments
- Cancer Treatment and Pharmacology
- Bone Tissue Engineering Materials
- Hearing, Cochlea, Tinnitus, Genetics
- Neuroscience and Neuropharmacology Research
- RNA Research and Splicing
- Genetic factors in colorectal cancer
- Cancer Genomics and Diagnostics
- Nerve injury and regeneration
- Cancer-related gene regulation
- NF-κB Signaling Pathways
- Gut microbiota and health
- Ion Channels and Receptors
- Botulinum Toxin and Related Neurological Disorders
- Signaling Pathways in Disease
- Cellular Mechanics and Interactions
- Phytochemistry and Biological Activities
Xi'an University of Architecture and Technology
2024
Shaoxing People's Hospital
2015-2024
Guangdong Academy of Medical Sciences
2019-2024
Guangdong Provincial People's Hospital
2019-2024
Southern Medical University
2024
Nanjing University of Chinese Medicine
2018-2024
Jiangsu Food and Pharmaceutical Science College
2024
Shaanxi University of Science and Technology
2024
Chinese PLA General Hospital
2021-2023
Tongji University
2014-2023
Abstract Purpose: To investigate expression, regulation, potential role and targets of miR-195 miR-497 in breast cancer. Experimental Design: The expression patterns were initially examined cancer tissues cell lines by Northern blotting quantitative real-time PCR. Combined bisulfite restriction analysis sequencing carried out to study the DNA methylation status genes. Breast cells stably expressing established their targets. Finally, normal, fibroadenoma employed analyze correlation between...
MiR-145 is known as a tumor suppressor in numerous human cancers. However, its role angiogenesis remains poorly defined. In this study, we found that miR-145 was significantly downregulated breast cancer tissues by using 106 cases of normal and well cells. exhibited inhibitory angiogenesis, cell growth invasion through the post-transcriptional regulation novel targets N-RAS VEGF-A. addition, provide evidence expression levels correlate inversely with malignancy stages tumors, although there...
Abstract Background Tactile and mechanical pain are crucial to our interaction with the environment, yet underpinning molecular mechanism is still elusive. Endophilin A2 (EndoA2) an evolutionarily conserved protein that documented in endocytosis pathway. However, role of EndoA2 regulation sensitivity its underlying mechanisms currently unclear. Methods Male female C57BL/6 mice (8–12 weeks) male cynomolgus monkeys (7–10 years old) were used experiments. Nerve injury-, inflammatory-,...
Abstract Clinically, Microtubule-targeted agents–induced neuropathic pain hampers chemotherapeutics for patients with cancer. Here, we found that application of paclitaxel or vincristine increased the protein and mRNA expression CXCL12 frequency amplitude miniature excitatory post synaptic currents (mEPSCs) in spinal dorsal horn neurons. Spinal local induced long-term potentiation nociceptive transmission mEPSCs. Inhibition using transgenic mice ( CXCL12−/+ ) neutralizing antibody siRNA...
Abstract The acidic tumor microenvironment provides an energy source driving malignant progression. Adaptation of cells to environment leads the emergence cancer stem cells. expression vitamin D receptor (VDR) is closely related initiation and development colorectal carcinoma (CRC), but its regulatory mechanism in CRC still unclear. Our study revealed that acidosis reduced VDR by downregulating peroxisome proliferator-activated delta (PPARD) expression. Overexpression effectively suppressed...
Summary It has been established that gut microbiota influences chicken growth performance and fat metabolism. However, whether affects by regulating metabolism remains unclear. Therefore, seven‐week‐old chickens with high or low body weight were used in the present study. There significant differences weight, breast leg muscle indices, cross‐sectional area of cells, suggesting different performance. The relative abundance caecal contents at genus level was compared 16S rRNA gene sequencing....
Neuropathic pain is a common neurobiological disease involving multifaceted maladaptations ranging from gene modulation to synaptic dysfunction, but the interactions between dysfunction and genes that are involved in persistent remain elusive. In present study, we found neuropathic induced by chemotherapeutic drug paclitaxel or L5 ventral root transection significantly impaired function of GABAergic synapses spinal dorsal horn neurons via reduction GAD67 expression. We also mir-500...
Palmitoylation of δ-catenin is critical to synapse plasticity and memory formation. We found that palmitoylation also instrumental in the development neuropathic pain. The abundances palmitoylated palmitoyl acyltransferase DHHC3 were increased dorsal root ganglion (DRG) sensory neurons rat models Inhibiting acyltransferases or decreasing abundance DRG by intrathecal injection 2-bromopalmitate shRNA, respectively, alleviated oxaliplatin nerve injury-induced pain rats. δ-catenin, which was...
Background The Camrelizumab Plus Apatinib in Patients with Advanced Cervical Cancer trial was a single-arm, phase II study that showed promising activity of the programmed death-1 (PD-1) inhibitor camrelizumab plus vascular endothelial growth factor receptor-2 apatinib patients advanced cervical cancer. However, predictive biomarkers for treatment outcomes are unknown. In this study, we aimed to identify potential predictors response PD-1 combination therapy. Methods Genomic profiling...
The expression patterns of the Dickkopf (Dkk) family proteins varies in different cancers. In present study, levels Dkk1 and Dkk3 were investigated clear cell renal carcinoma (ccRCC) tissues. serum also examined patients with ccRCC, association between clinicopathological features Dkk was investigated. Serum quantified using ELISA 64 ccRCC 30 healthy individuals (controls). analyzed tumor adjacent normal tissues obtained from (n=20) quantitative polymerase chain reaction (qPCR), western blot...
Currently there is no effective treatment available for clinical patients suffering from neuropathic pain induced by chemotherapy paclitaxel. Puerarin a major isoflavonoid extracted the Chinese medical herb kudzu root, which has been used of cardiovascular disorders and brain injury. Here, we found that puerarin dose-dependently alleviated paclitaxel-induced pain. At same time, preferentially reduced excitability blocked voltage-gated sodium (Nav) channels dorsal root ganglion (DRG) neurons...
Abstract Effective treatments for patients suffering from heat hypersensitivity are lacking, mostly due to our limited understanding of the pathogenic mechanisms underlying this disorder. In nervous system, activating transcription factor 4 (ATF4) is involved in regulation synaptic plasticity and memory formation. Here, we show that ATF4 plays an important role nociception. Indeed, loss mouse dorsal root ganglion (DRG) neurons selectively impairs sensitivity. Mechanistically, interacts with...
Breast cancer is the second highest cause of carcinoma-related death caused by distant metastasis in women. Estrogen receptor (ER), human epidermal growth factor 2, (HER2) and progesterone (PR) are three classified makers breast cancer, which defined as ER+, HER2+, most serious ER-PR-HER2- (triple-negative). It well known that ErbB2 (V-Erb-B2 avian erythroblastic leukemia viral oncogene homolog 2) plays an important part cancer. However, molecular mechanisms underlying action needs to be...
Abstract Addiction‐related behaviors, such as conditioned place preference (CPP), require animals to remember an association between environmental cue and drug treatment, exposure is one of the key contributing factors relapse. However, how central neural circuit participates in formation CPP induced by stimulus morphine‐paired environment remains unknown. In present study, we found that reexposure significantly increased activity hippocampal CA3 neurons, excitability GABAergic neurons...
It is well known that nuclear factor-kappaB (NF-κB) regulates neuronal structures and functions by transcription. Here, we showed phospho-p65 (p-p65), an active form of NF-κB subunit, reversibly interacted with Nav1.7 channels in the membrane dorsal root ganglion (DRG) neurons rats. The interaction increased currents slowing inactivation facilitating their recovery from inactivation, which may increase resting state ready for activation. In cultured DRG TNF-α upregulated p-p65 enhanced...
Intracellular tension activity plays a crucial role in cytotoxic brain edema and astrocyte swelling. Here, few genetically encoded FRET-based probes were designed to detect cytoskeletal structural optically, including their magnitude vectors. The swelling resulted GFAP increment, which is associated with the antagonistic effect of inward microfilaments (MFs) microtubules (MTs) forces. In glutamate-induced swelling, rise from outward ion protein nanoparticle-induced osmotic pressure (PN-OP)...