A5032058665- Pain Mechanisms and Treatments
- Cancer Treatment and Pharmacology
- Botulinum Toxin and Related Neurological Disorders
- Signaling Pathways in Disease
- Peripheral Neuropathies and Disorders
- Neuroscience and Neuropharmacology Research
- Nerve injury and regeneration
- RNA modifications and cancer
- Multiple Myeloma Research and Treatments
- Neuropeptides and Animal Physiology
- COVID-19 impact on air quality
- Anesthesia and Pain Management
- Pharmacological Receptor Mechanisms and Effects
- Peptidase Inhibition and Analysis
- Neurotransmitter Receptor Influence on Behavior
- Anesthesia and Sedative Agents
- Pharmacological Effects of Natural Compounds
- Central Venous Catheters and Hemodialysis
- Plant-based Medicinal Research
- COVID-19 epidemiological studies
- Hemodynamic Monitoring and Therapy
- Neuroinflammation and Neurodegeneration Mechanisms
- Veterinary Pharmacology and Anesthesia
- Ion channel regulation and function
- Silk-based biomaterials and applications
Sun Yat-sen University Cancer Center
2015-2025
Sun Yat-sen University
2015-2025
State Key Laboratory of Oncology in South China
2015-2022
Bridge University
2022
Second Military Medical University
2017
Changhai Hospital
2017
Committee on Publication Ethics
2016
University of Michigan
2010-2014
Background: HIV-associated sensory neuropathy (HIV-SN) is one of the most common forms peripheral neuropathy, affecting about 30% people with acquired immune deficiency syndrome (AIDS). The symptoms HIV-SN are dominated by neuropathic pain. Glia activation in spinal cord has become an attractive target for attenuating chronic This study will investigate role TNFα released from glia HIV-related Results: Peripheral gp120 application into rat sciatic nerve induced mechanical allodynia more than...
Abstract Clinically, Microtubule-targeted agents–induced neuropathic pain hampers chemotherapeutics for patients with cancer. Here, we found that application of paclitaxel or vincristine increased the protein and mRNA expression CXCL12 frequency amplitude miniature excitatory post synaptic currents (mEPSCs) in spinal dorsal horn neurons. Spinal local induced long-term potentiation nociceptive transmission mEPSCs. Inhibition using transgenic mice ( CXCL12−/+ ) neutralizing antibody siRNA...
Systemic administration of oxaliplatin has no effect on the tumors in central nervous system (CNS) due to limited concentration cerebrospinal fluid (CSF), while it was clinically reported that can induce acute encephalopathy. Currently, impairment neuronal functions CNS after systemic remains uninvestigated.The von Frey test and plantar were performed evaluate neuropathic pain behavior a single intraperitoneal (4 mg/kg) rats. Inductively coupled plasma-mass spectrometry, electrophysiologic...
Neuropathic pain is a common neurobiological disease involving multifaceted maladaptations ranging from gene modulation to synaptic dysfunction, but the interactions between dysfunction and genes that are involved in persistent remain elusive. In present study, we found neuropathic induced by chemotherapeutic drug paclitaxel or L5 ventral root transection significantly impaired function of GABAergic synapses spinal dorsal horn neurons via reduction GAD67 expression. We also mir-500...
Antineoplastic agents, including vincristine, often induce neuropathic pain and magnesium deficiency clinically, but the causal link between them has not been determined. No drug is available for treating this form of pain.Injection vincristine (0.1 mg · kg day, intraperitoneally, 10 days) was used to nociceptive sensitization, which accessed with von Frey hairs plantar tester in adult male Sprague-Dawley rats. Magnesium-L- threonate administered through drinking water (604 day)....
A totally implantable venous access device (TIVAD) provides reliable, long-term vascular and improves patients' quality of life. The wide use TIVADs is associated with important complications. meta-analysis was undertaken to compare the internal jugular vein (IJV) subclavian (SCV) as percutaneous site for TIVAD determine whether IJV has any advantages.All randomized controlled trials (RCTs) cohort studies assessing two sites, SCV, were retrieved from PubMed, Web Science, Embase, OVID EMB...
Astrocytes are closely linked to depression, and the prefrontal cortex (PFC) is an important brain region involved in major depressive disorder (MDD). However, underlying mechanism by which astrocytes within PFC contribute MDD remains unclear. Using single-nucleus RNA sequencing analyses, we show a significant reduction attenuated pleiotrophin-protein tyrosine phosphatase receptor type Z1 (PTN-PTPRZ1) signaling astrocyte-to-excitatory neuron communication of male patients. We find reduced...
Long-term use of opioids such as morphine has negative side effects, analgesic tolerance and morphine-induced hyperalgesia (MIH). These effects limit the clinical efficacy morphine. Elucidation mechanisms identification feasible effective methods or treatment targets to solve this phenomenon are important. Here, we discovered that YTHDF1 TNF receptor-associated factor 6 (TRAF6) crucial for MIH. The m6A reader positively regulated translation TRAF6 mRNA, chronic treatments enhanced...
Abstract Aversion refers to feelings of strong dislike or avoidance toward particular stimuli situations. can be caused by pain and has a long-term negative impact on physical mental health. also drug abuse withdrawal, resulting in people with substance use disorder relapse. However, the mechanisms underlying aversion remain unclear. The ventrolateral periaqueductal gray (vlPAG) is considered play key role aversive behavior. Our study showed that inhibition vlPAG GABAergic neurons...
In the human immunodeficiency virus (HIV)-associated sensory neuropathy, neuropathic pain associated with use of nucleoside reverse transcriptase inhibitors (NRTIs) in patients HIV/acquired syndrome is clinically common. While evidence demonstrates that influenced by neuroinflammatory events include proinflammatory molecules, tumor necrosis factor-α (TNF-α), stromal cell-derived factor 1-α (SDF1-α), and C-X-C chemokine receptor type 4 (CXCR4), detailed mechanisms which NRTIs contribute to...
In the anesthesia management of percutaneous liver tumor ablation, requirement analgesia is very strict. Currently, intravenous commonly used, such as remifentanil combined with sedative drugs. However, pain relief not instantaneous after increasing dosage remifentanil. Esketamine, a medium- or long-term analgesic drug, does inhibit respiration to maintain patient comfort during ablation and reduces consumption Therefore, this experiment was designed investigate potential combinational...
The aim of this study was to investigate the mechanism oxaliplatin in induction neuropathic pain as a symptom Chemotherapy-Induced Peripheral Neuropathy (CIPN).The CIPN rat model induced with one-time injection oxaliplatin, and paw withdrawal response determined using von Frey filaments. Paw Withdrawal Threshold (PWT) value recorded Dorsal Horn (DH) Root Ganglion (DRG) tissues were collected. mRNA protein levels Calcineurin (CaN), Nuclear Factor Activated T cells (NFAT), other relevant...