A5026225105- Bone Tissue Engineering Materials
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- Advanced Nanomaterials in Catalysis
- Pain Mechanisms and Treatments
- Dental Implant Techniques and Outcomes
- Metal-Organic Frameworks: Synthesis and Applications
- Protein Hydrolysis and Bioactive Peptides
- Graphene and Nanomaterials Applications
- Spectroscopy Techniques in Biomedical and Chemical Research
- Nanoparticles: synthesis and applications
- Dental materials and restorations
- Geoscience and Mining Technology
- RNA Interference and Gene Delivery
- Ion channel regulation and function
- Polysaccharides and Plant Cell Walls
- Analytical Chemistry and Chromatography
- Medicinal Plant Research
- Polymer composites and self-healing
- Neuroscience and Neuropharmacology Research
- Ultrasound and Cavitation Phenomena
- Advanced materials and composites
- Cell death mechanisms and regulation
- Cancer Research and Treatment
- Botulinum Toxin and Related Neurological Disorders
Hainan University
2014-2024
Shandong Maternal and Child Health Hospital
2024
Shandong University of Technology
2022
Materials Science & Engineering
2020
Wuhan University of Technology
2003-2015
Harbin Normal University
2014
Sichuan University
2013
China Railway First Survey and Design Institute Group Co. Ltd.
2012
China Railway Fifth Survey and Design Institute Group
2012
American Society of Safety Professionals
2005
Hydroxyapatite (HAP), similar to inorganic phase in bones, shows good biocompatibility and bioactivity as bone defect repairing material. Recently, nanoscaled HAP the special properties differing from bulk physics, chemistry biology. This paper demonstrates that nanoparticle (nHAP) possesses ability for inhibiting cancer cell growth vitro vivo. In vitro, after treatment with nHAP 3 days, proliferation of human cells are inhibited by more than 65% less 30% normal cells. vivo, injection...
Chemotherapy is still an important and effective clinical treatment for cancer. However, individual drugs hardly achieve precise controlled release targeted therapy, thus resulting in unavoidable side effects. Fortunately, the emergence of drug carriers expected to solve above problems. In this work, MOF-on-MOF strategy was adopted encapsulate DOX into double-layer NH2-MIL-88B fabricate a core–shell-structured DOX@NH2-MIL-88B-On-NH2-MIL-88B (DMM) then realize pH GSH dual-responsive release....
Abstract Background Tactile and mechanical pain are crucial to our interaction with the environment, yet underpinning molecular mechanism is still elusive. Endophilin A2 (EndoA2) an evolutionarily conserved protein that documented in endocytosis pathway. However, role of EndoA2 regulation sensitivity its underlying mechanisms currently unclear. Methods Male female C57BL/6 mice (8–12 weeks) male cynomolgus monkeys (7–10 years old) were used experiments. Nerve injury-, inflammatory-,...
Abstract BACKGROUND A polysaccharide was purified in this study, which acquired from the fermentation broth of Dendrobium officinale Kimura et Migo. We aimed to investigate structural features and bioactivity polysaccharide. RESULTS The main fraction (i.e., DOP‐1) obtained. High‐performance gel permeation chromatography (HPGPC) revealed that molecular weight DOP‐1 447.48 kDa. Galactose, glucose mannose were found be present via monosaccharide composition analysis, at a ratio 1:1.79:6.71....
Controlling the crystal size and surface chemistry of MOF materials, understanding their multifunctional effect are great significance for biomedical applications systems. Herein, we designed synthesized a new anionic MOF, ZJU-64-NSN, which features 1D channels decorated with highly polarized thiadiazole groups, its could be systematically tuned from 200 μm to 300 nm through green simple approach. As result, optimal nanosized ZJU-64-NSN is found enable an ultrafast loading cationic drug...
Currently there is no effective treatment available for clinical patients suffering from neuropathic pain induced by chemotherapy paclitaxel. Puerarin a major isoflavonoid extracted the Chinese medical herb kudzu root, which has been used of cardiovascular disorders and brain injury. Here, we found that puerarin dose-dependently alleviated paclitaxel-induced pain. At same time, preferentially reduced excitability blocked voltage-gated sodium (Nav) channels dorsal root ganglion (DRG) neurons...
Cancer nanovaccines have been widely explored to enhance immunotherapy efficiency, in which the significant irritation of antigen-specific cytotoxic T cells (CTLs) is critical point. In this study, we developed a pH and reduction dual-sensitive nanovaccine (PMSN@OVA-MPN) composed two parts. The inner part was made up polyethyleneimine (PEI)-modified mesoporous silica nanoparticles (MSNs) loaded with model antigen ovalbumin (OVA) outer disulfide bond-involved metal–phenolic networks (MPNs) as...
Abstract Effective treatments for patients suffering from heat hypersensitivity are lacking, mostly due to our limited understanding of the pathogenic mechanisms underlying this disorder. In nervous system, activating transcription factor 4 (ATF4) is involved in regulation synaptic plasticity and memory formation. Here, we show that ATF4 plays an important role nociception. Indeed, loss mouse dorsal root ganglion (DRG) neurons selectively impairs sensitivity. Mechanistically, interacts with...
To establish an experimental model for culturing rabbit osteoblasts in vitro, the were isolated from calvarial bone of a 15-day old using method pieces medium after they had been digested by enzyme 15 min. The acquired cells assayed cell morphology, alkaline phosphatase activity and production mineralized matrix. results showed that morphologic characteristics some biological behaviours osteoblasts. Based on primary isolation combining digestion with explants, novel vitro was established,...
Three-Spot seahorse is a traditional medicine in Asian countries. However, the alcohol extract largely unknown for its anti-inflammatory activity. This study aimed at elucidating fraction of potent activity seahorse. A systematic solvent extraction method liquid-liquid fractionation ethanol crude gave four fractions petroleum ether (PE), and ethyl acetate (EtOAc), water saturated butanol (n-BuOH), (H2O). In this study, PE was selected further after preliminary screening test, connected to...
The present study attempts to investigate the anti-inflammatory potential of isolated lipid extracts three-spot seahorse which is rare marine bony fish. Petroleum ether (PE) extract was obtained from systematic solvent extraction after reflux with 95% ethanol. FrIV collected silica gel column chromatography, and neutral lipids (NL), glycolipids (GL), phospholipids (PL) were separated FrIV. Basic compositions detected analyzed via thin layer chromatography (TLC) Fourier transform infrared...
Abstract Mechanical allodynia is a debilitating condition for millions of patients with chronic pain. can manifest in distinct forms, including brush-evoked dynamic and filament-evoked static allodynia. In the nervous system, forkhead protein Foxo1 plays critical role neuronal structures functions. However, somatosensory signal remains unclear. Here, we found that selectively regulated mechanical knockdown decreased sensitivity to stimuli normal rats attenuated rat models neuropathic,...
Angiotensin-converting enzyme (ACE) inhibitory peptides were found to alleviate acute hepatitis significantly. In this study, we purified and identified ACE peptide from cashew evaluate its protective role on alcohol-induced in mice.The by using consecutive chromatographic techniques. One of these (FETISFK) exhibited the highest inhibition rate (91.04 ± 0.31%). vivo, results showed that decreased levels alanine aminotransferase (ALT) aspartate (AST) caused alcohol exposure. Moreover, it...