A5001015118- Cancer Mechanisms and Therapy
- Immunotherapy and Immune Responses
- Immune Cell Function and Interaction
- Macrophage Migration Inhibitory Factor
- Immune cells in cancer
- RNA Interference and Gene Delivery
- Epigenetics and DNA Methylation
- Phagocytosis and Immune Regulation
- Hepatitis B Virus Studies
- Immune responses and vaccinations
- Cancer Immunotherapy and Biomarkers
- Cytokine Signaling Pathways and Interactions
- Adenosine and Purinergic Signaling
- Liver Disease and Transplantation
- Transplantation: Methods and Outcomes
- Inflammasome and immune disorders
- MicroRNA in disease regulation
- Toxin Mechanisms and Immunotoxins
- Peptidase Inhibition and Analysis
- Galectins and Cancer Biology
- Animal Virus Infections Studies
- IL-33, ST2, and ILC Pathways
- Cytomegalovirus and herpesvirus research
- T-cell and B-cell Immunology
- COVID-19 Impact on Reproduction
Tongji Hospital
2022-2025
Huazhong University of Science and Technology
2022-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2022-2025
Ministry of Education of the People's Republic of China
2022-2024
Saudi Center for Organ Transplantation
2023-2024
RIKEN Center for Sustainable Resource Science
2023
Zhejiang Normal University
2023
University of Cologne
2023
North University of China
2023
Guangdong Medical College
2022-2023
Rationale: Tumor cells possess sophisticated strategies to circumvent immune detection, including the modulation of endogenous checkpoints, particularly those within B7 family. Elucidating mechanisms that govern induction family molecules is crucial for advancement immunotherapy. Lysine lactylation (Kla), a newly identified epigenetic modification, suggested may play role in reshaping tumor microenvironment and facilitating evasion. Methods: We analyzed glycolysis pathway's enrichment...
Innate immune cells remember Immunological memory is a phenomenon by which can quickly recognize an antigen that the host has previously encountered. Certain of innate system exhibit memory-like responses know as trained immunity. Rapid, antigen-specific secondary (anamnestic) were long thought to be domain B and T cells. However, Dai et al. report monocytes macrophages acquire specific for particular major histocompatibility complex I antigens using paired A-type immunoglobulin-like...
Epigenetic therapy using histone deacetylase inhibitors (HDACi) has shown promise in clinical trials for the treatment of human malignancies. In addition to immediate effects on tumour cell growth, HDACi upregulates expression MHC class I-related chain molecules A and B (MICA MICB), resulting an enhanced susceptibility cells natural killer cell-mediated lysis. The molecular mechanism underlying is still unclear.The transcriptional regulation suberoylanilide hydroxamic acid (SAHA)-mediated...
Abstract Glucocorticoid-induced TNFR-related protein (GITR) is a costimulatory molecule with diverse effects on effector T cells and regulatory (Tregs), but the underlying mechanism remains poorly defined. Here we demonstrate that GITR ligation subverts induction of Foxp3 + Tregs directs activated CD4 to Th9 cells. Such GITR-mediated iTreg enhances anti-tumour immunity in vivo . Mechanistically, upregulates NF-κB family member p50, which recruits histone deacetylases locus produce ‘closed’...
Naive CD4+ T cells can be converted to Foxp3+ regulatory (Tregs) in the periphery (iTregs), where induction of Foxp3 gene expression is central Treg differentiation. OX40 signaling known inhibit and induction, but underlying mechanisms remain poorly defined. Here, we found that costimulation activates two distinct molecular pathways suppress freshly activated naive cells. Specifically, upregulates BATF3 BATF, which produce a closed chromatin configuration repress Sirt1/7-dependent manner....
Abstract A chronic viral or tumor microenvironment can push T cells to exhaustion by promoting coinhibitory ligand expression. However, how host factors control expression and whether infection breaks this during progress is unknown. Here we show a close negative correlation between SALL4 PD-L1 miR-200c in tumors from 98 patients with HBV-related hepatocellular carcinoma. correlates negatively expression, lower levels of higher survive longer. Moreover, over-expression antagonizes...
Macrophages infiltrating the allografts are heterogeneous, consisting of proinflammatory (M1 cells) as well antiinflammatory and fibrogenic phenotypes (M2 cells); they affect transplantation outcomes via diverse mechanisms. Here we found that macrophage polarization into M1 M2 subsets was critically dependent on tumor necrosis factor receptor–associated 6 (TRAF6) mammalian target rapamycin (mTOR), respectively. In a heart transplant model showed macrophage-specific deletion TRAF6...
Abstract Hepatitis B virus (HBV) persistence aggravates hepatic immunotolerance, leading to the failure of cell-intrinsic type I interferon and antiviral response, but whether how HBV-induced hepatocyte-intrinsic tolerance influences systemic adaptive immunity has never been reported, which is becoming major obstacle for chronic HBV therapy. In this study, an HBV-persistent mouse, established by hydrodynamic injection HBV-genome-containing plasmid, exhibited not only also immunotolerance...
Th9 cells are prominently featured in allergic lung inflammation, but the mechanism that regulates IL-9 induction T helper remains poorly defined. Here we demonstrate formation of super-enhancers (SEs) is critical robust and assembly Il9 SEs Th requires OX40-triggered chromatin acetylation. Mechanistically, found OX40 costimulation induces RelB expression, which recruits histone acetyltransferase p300 to locus catalyze H3K27 This allows binding SE factor Brd4 organize complex, turn drives...
Tissue-resident immune cells play a key role in local and systemic responses. The liver, particular, hosts large number of invariant natural killer T (iNKT) cells, which are involved diverse However, the mechanisms that regulate survival homeostasis liver iNKT poorly defined. Here we have found constitutively express costimulatory TNF superfamily receptor OX40 stimulation results massive pyroptotic death characterized by release potent proinflammatory cytokines induce injury. This OX40/NKT...
Macrophages exhibit diverse phenotypes and functions; they are also a major cell type infiltrating chronically rejected allografts. The exact roles of macrophages in chronic graft loss remain poorly defined. In the present study, we used mouse heart transplant model to examine allograft rejection. We found that treatment C57BL/6 mice with CTLA4 immunoglobulin fusion protein (CTLA4-Ig) prevented acute rejection Balb/c but allowed develop over time, characterized by prominent neointima...
Abstract The Warburg effect‐related metabolic dysfunction of the tricarboxylic acid (TCA) cycle has emerged as a hallmark various solid tumors, particularly renal cell carcinoma (RCC). RCC is characterized by high immune infiltration and thus recommended for immunotherapeutic interventions at an advanced stage in clinical guidelines. Nevertheless, limited benefits immunotherapy have prompted investigations into underlying mechanisms, leading to proposal dysregulation‐induced immunoevasion...
Melanoma is the deadliest form of commonly encountered skin cancer, and has fast propagating highly invasive characteristics. Pim-3, a expressed oncogene in melanoma, conserved serine/threonine kinase with various biological activities, such as proliferation-accelerating anti-apoptosis effects on cancer progression. However, whether Pim-3 regulates melanoma metastasis not been determined. Here, we constructed Pim-3–silencing short hairpin RNA (sh-Pim-3), TLR7-stimulating ssRNA dual-function...
: CD8
Abstract Tumorigenesis is an immortalization process in which the growth of normal cells uncontrolled and programmed cell death suppressed. Molecular biologic immunologic studies have revealed that aberrant expression some proto-oncogenes boosts proliferation inhibits apoptosis, vital for tumor development. The hypofunction host immune system also drives development metastasis malignant tumors. Pim-3, a member Pim family, aberrantly expressed several cancers. Data suggest Pim-3 apoptosis by...
// Yun Guan 1 , Weiqun Li Zhaohua Hou Qiuju Han Peixiang Lan Jian Zhang Zhigang Tian 2 and Cai Institute of Immunopharmacology Immunotherapy, School Pharmaceutical Sciences, Shandong University, Jinan, Shandong, China Immunology, Life University Science Technology China, Hefei, Anhui, Correspondence to: Zhang, email: Keywords : hepatitis B virus; MICA; hepatocarcinoma; GATA-2; GATA-3; Immunology Microbiology Section; Immune response; Immunity Received March 30, 2016 Accepted August 01,...