A5040894984- Renal cell carcinoma treatment
- Renal and related cancers
- SARS-CoV-2 and COVID-19 Research
- COVID-19 Clinical Research Studies
- Bladder and Urothelial Cancer Treatments
- Cancer Genomics and Diagnostics
- Cancer-related gene regulation
- Epigenetics and DNA Methylation
- COVID-19 epidemiological studies
- Ferroptosis and cancer prognosis
- Prostate Cancer Diagnosis and Treatment
- Urinary Bladder and Prostate Research
- Cancer, Lipids, and Metabolism
- Circular RNAs in diseases
- Pancreatic and Hepatic Oncology Research
- Cancer, Hypoxia, and Metabolism
- RNA modifications and cancer
- SARS-CoV-2 detection and testing
- COVID-19 Pandemic Impacts
- Pediatric Urology and Nephrology Studies
- Cancer Immunotherapy and Biomarkers
- Radiomics and Machine Learning in Medical Imaging
- Multiple and Secondary Primary Cancers
- AI in cancer detection
- Pelvic floor disorders treatments
Renji Hospital
2020-2025
Shanghai Jiao Tong University
2013-2025
Tongji University
2012-2023
Shanghai Tenth People's Hospital
2011-2023
State Key Laboratory of Oncogene and Related Genes
2023
Shanghai First People's Hospital
2018-2022
University of Rochester Medical Center
2022
Fudan University
2020
Huashan Hospital
2020
MSCI (China)
2020
It is of great urgency to explore useful prognostic markers for patients with clear cell renal carcinoma (ccRCC). Prognostic models based on ferroptosis-related gene (FRG) in ccRCC poorly reported now.
Background: Circular RNAs (circRNAs) have been identified as essential regulators in a plethora of cancers. Nonetheless, the mechanistic functions circRNAs Renal Cell Carcinoma (RCC) remain largely unknown. Methods: In this study, we aimed to identify novel that regulate RCC epithelial-mesenchymal transition (EMT), and subsequently determine their regulatory mechanisms clinical significance. Results: circPRRC2A was by circRNA microarray validated qRT-PCR. The role metastasis evaluated both...
Abstract Single-cell and spatial transcriptome sequencing, two recently optimized sequencing methods, are increasingly used to study cancer related diseases. Cell annotation, particularly for malignant cell is essential crucial in-depth analyses in these studies. However, current algorithms lack accuracy generalization, making it difficult consistently rapidly infer cells from pan-cancer data. To address this issue, we present Cancer-Finder, a domain generalization-based deep-learning...
Abstract Purpose Although microRNAs (miRNAs) were revealed as crucial modulators in tumor metastasis and target therapy, our understanding of their roles metastatic renal cell carcinoma (mRCC) Sunitinib treatment was limited. Here we sought to identify human miRNAs that acted key regulators cancer treatment. Experimental design We focused on 2 published microarray data select out anchored miRNA then explored the miR-452-5p both vitro vivo, which downregulated after while upregulated (RCC)...
Abstract Traditional histopathology performed by pathologists the naked eye is insufficient for accurate and efficient diagnosis of bladder cancer (BCa). We collected 643 H&E‐stained BCa images from Shanghai General Hospital The Cancer Genome Atlas (TCGA). constructed cross‐verified automatic prognosis models performing a machine learning algorithm based on pathomics data. Our study indicated that high diagnostic efficiency learning‐based model was observed in patients with BCa, area...
Abstract Accumulating studies have confirmed that PIWI-interacting RNAs (piRNAs) are considered epigenetic effectors in cancer. We performed piRNA microarray expression analysis on renal cell carcinoma (RCC) tumor tissues and paired normal a series of vivo vitro experiments to explore piRNAs associated with RCC progression investigate their functional mechanisms. found piR-1742 was highly expressed tumors patients high had poor prognosis. Inhibition significantly reduced growth xenograft...
Previous studies have reported that hyperoside and quercetin in combination (QH; 1:1) inhibited the growth of human leukemia cells. The aim present study was to investigate anti‑cancer effect QH on prostate cancer results demonstrated decreased production reactive oxygen species (ROS) increased antioxidant capacity PC3 cells at various concentrations (2.5‑60 µg/ml) with peak inhibition augmentation changes 3.22‑ 3.00‑fold, respectively. Following treatment for 48 72 h, IC50-values were 19.7...
Abstract Due to the complicated histopathological characteristics of renal neoplasms, traditional distinguishing clear cell carcinoma (ccRCC) by naked eyes experienced pathologist remains labor intensive and time consuming. Here, we extracted quantitative features hematoxylin‐eosin‐stained images using CellProfiler performed machine learning method develop verify a novel computational recognition digital pathology for diagnosis prognosis ccRCC patients in training, test external validation...
Abstract Cepharanthine (CEP) is a natural remedy that potently inhibits SARS-CoV-2 activity both in vitro and vivo. To evaluate the efficacy safety of CEP compared with placebo adults asymptomatic or mild coronavirus disease 2019 (COVID-19), we conducted proof-of-concept, double-blind, randomized, placebo-controlled trial. Patients were randomized to receive 120 mg/day CEP, 60 for 5 days. Main outcome was time from randomization negative nasopharyngeal swab safety. Among 262 participants,...
ObjectivesTo describe the epidemiological, clinical, and household transmission characteristics of pediatric COVID-19 cases in Shanghai, China.MethodsPediatric patients with hospitalized Shanghai from March-May 2022 were enrolled this retrospective, multicenter cohort study. The symptoms risk factors associated disease severity analyzed.ResultsIn total, 2620 (age range, 24 days-17 years) Of these, 1011 (38.6%) asymptomatic, whereas 1415 (54.0%), 190 (7.3%), 4 (0.2%) developed mild, moderate,...
The expression patterns of the Dickkopf (Dkk) family proteins varies in different cancers. In present study, levels Dkk1 and Dkk3 were investigated clear cell renal carcinoma (ccRCC) tissues. serum also examined patients with ccRCC, association between clinicopathological features Dkk was investigated. Serum quantified using ELISA 64 ccRCC 30 healthy individuals (controls). analyzed tumor adjacent normal tissues obtained from (n=20) quantitative polymerase chain reaction (qPCR), western blot...
CD44 is a critical cell-surface glycoprotein. However, its prognostic significance and correlation with tumor-infiltrating lymphocytes in clear cell renal carcinoma (ccRCC) are not well-understood.The mRNA protein levels of ccRCC were assessed. The value was analyzed the TCGA PrognoScan databases. functional enrichment immune infiltrates analyses conducted. STRING database used to analyze interactions CD44. Tissue array, western blot, qRT-PCR, transwell assay performed determine expression...
The aim of the present study was to compare efficacy and safety fosfomycin combinational therapy with other antibiotics for treatment infections caused by carbapenem-resistant Klebsiella pneumoniae (CRKP). This retrospective cohort examined 104 cases sepsis CRKP occurring between January 2012 November 2014 in Shanghai Tenth People's Hospital. Three categories patient outcome were assessed: Survival/mortality, duration intensive care unit stays medical ventilation. Univariate ordinal analyses...
It is of great urgency to explore useful prognostic markers and develop a robust model for patients with clear-cell renal cell carcinoma (ccRCC). Three independent patient cohorts were included in this study. We applied high-level neural network based on TensorFlow construct the by using deep learning algorithm. The learning-based (FB-risk) could perform well predicting survival status 5-year follow-up, which also significantly distinguish high overall risk three ccRCC pan-cancer cohort....
Hypertension is a common complication in hemodialysis patients during erythropoietin (EPO) treatment. The underlying mechanisms of EPO-induced hypertension still remain to be determined. Increased transient receptor potential canonical (TRPC) channels have been associated with hypertension. Now, TRPC gene expression was investigated using quantitative real-time RT-PCR and immunoblotting cultured human endothelial cells monocytes from patients. EPO dose-dependently increased TRPC5 mRNA cells....
Traditional histopathology performed by pathologists through naked eyes is insufficient for accurate survival prediction of bladder cancer (BCa). In addition, how neutrophil to lymphocyte ratio (NLR) could be used prognosis BCa patients has not been fully understood. this study, we collected 508 whole slide images (WSIs) hematoxylin–eosin strained slices and NLR value from the Shanghai General Hospital The Cancer Genome Atlas (TCGA), which were further processed nuclear segmentation....