A5100767237- Kidney Stones and Urolithiasis Treatments
- Sexual function and dysfunction studies
- Bladder and Urothelial Cancer Treatments
- Hormonal and reproductive studies
- Pediatric Urology and Nephrology Studies
- Prostate Cancer Treatment and Research
- Renal cell carcinoma treatment
- Urinary and Genital Oncology Studies
- Urological Disorders and Treatments
- Ferroptosis and cancer prognosis
- Urinary Bladder and Prostate Research
- Prostate Cancer Diagnosis and Treatment
- Ureteral procedures and complications
- Epigenetics and DNA Methylation
- Urinary Tract Infections Management
- Renal and Vascular Pathologies
- Parathyroid Disorders and Treatments
- Renal and related cancers
- Cancer, Lipids, and Metabolism
- Cancer Immunotherapy and Biomarkers
- Cancer-related molecular mechanisms research
- Urologic and reproductive health conditions
- Hypothalamic control of reproductive hormones
- Sperm and Testicular Function
- Sexuality, Behavior, and Technology
Tongji Hospital
2016-2025
Huazhong University of Science and Technology
2016-2025
Hazard Community and Technical College
2024
Bladder Cancer Advocacy Network
2024
Specific Technologies (United States)
2024
Renmin Hospital of Wuhan University
2024
Harbin Institute of Technology
2024
Wuhan University
2024
Wuhan National Laboratory for Optoelectronics
2013-2020
Wuhan University of Science and Technology
2020
Abstract Objectives Coronavirus disease 2019 (COVID‐19) is rapidly spreading worldwide. Lianhua Qingwen capsule (LQC) has shown therapeutic effects in patients with COVID‐19. This study aimed to discover its molecular mechanism and provide potential drug targets. Materials Methods An LQC target COVID‐19–related gene set was established using the Traditional Chinese Medicine Systems Pharmacology database seven disease‐gene databases. Gene ontology (GO), Kyoto Encyclopedia of Genes Genomes...
BACKGROUNDCurrent methods for the detection and surveillance of bladder cancer (BCa) are often invasive and/or possess suboptimal sensitivity specificity, especially in early-stage, minimal, residual tumors.METHODSWe developed an efficient method, termed utMeMA, urine tumor DNA methylation at multiple genomic regions by MassARRAY. We identified BCa-specific markers combined analyses cohorts from Sun Yat-sen Memorial Hospital (SYSMH), The Cancer Genome Atlas (TCGA), Gene Expression Omnibus...
The coronavirus disease 2019 (COVID-19) has been spreading all over the world since December 2019. However, medical information regarding urogenital involvement in recovered COVID-19 patients is limited or unknown.To comprehensively evaluate patients.Men aged between 20 years and 50 who were diagnosed with SARS-CoV-2 infection when study was conducted enrolled our study. Demographic clinical characteristics, history of hospitalization collected analyzed. Urine, expressed prostatic secretions...
Abstract Clear cell renal carcinoma (ccRCC) is a complex disease with remarkable immune and metabolic heterogeneity. Here we perform genomic, transcriptomic, proteomic, metabolomic spatial transcriptomic analyses on 100 patients ccRCC from the Tongji Hospital RCC (TJ-RCC) cohort. Our analysis identifies four subtypes including De-clear differentiated (DCCD)-ccRCC, subtype distinctive features. DCCD cancer cells are characterized by fewer lipid droplets, reduced activity, enhanced nutrient...
PURPOSE For patients with metastatic hormone-sensitive prostate cancer (mHSPC), delaying progression to castration-resistant disease is important not only for overall survival (OS) but also patients' quality of life. Darolutamide plus androgen-deprivation therapy (ADT) docetaxel improved OS versus ADT and in mHSPC. The ARANOTE trial evaluated darolutamide without chemotherapy METHODS In this global phase III trial, were randomly assigned 2:1 receive 600 mg twice daily or placebo, concomitant...
The coronavirus disease 2019 (COVID-19) pandemic remains threatening to women and children, but clinical evidence regarding during pregnancy, puerperium lactation is limited. We assessed immunologic features of breastfeeding advice provided mother–infant pairs. This observational analysis was conducted in a tertiary-care centre Wuhan, China. Pregnant patients with laboratory-confirmed COVID-19 who delivered hospitalization were enrolled. Clinical characteristics serial specimens the pairs...
Background Erectile dysfunction (ED) occurs more frequently and causes a worse response to the first-line therapies in diabetics compared with non-diabetic men. Corpus cavernosum vascular plays pivotal role occurrence of diabetes mellitus ED (DMED). The aim this study was investigate protective effects glucagon-like peptide-1 (GLP-1) analog liraglutide on explore underlying mechanisms vivo vitro. Methods Type 1 induced rats by streptozotocin, apomorphine test for screening DMED model...
Urolithiasis is common worldwide and can predispose to urinary tract infections renal failure. We aimed explore the global, regional, national burden of urolithiasis between 1990 2019, stratified by sex, age, sociodemographic index (SDI).From data on number incident cases urolithiasis, associated deaths, disability-adjusted life years (DALYs) were extracted from 2019 Global Burden Disease (GBD) study. The trends for incidence rate, mortality, DALYs evaluated using estimated annual percentage...
Treatment options are limited for patients with high-risk non-muscle-invasive bladder cancer (NMIBC) disease recurrence after bacillus Calmette-Guérin (BCG) treatment and who ineligible for/refuse radical cystectomy. FGFR alterations commonly detected in NMIBC. We evaluated the activity of oral erdafitinib, a selective pan-fibroblast growth factor receptor (FGFR) tyrosine kinase inhibitor, versus intravesical chemotherapy NMIBC select FGFR3/2 following BCG treatment.
The role of tumor-associated macrophages (TAMs), along with the regulatory mechanisms underlying distinct macrophage activation states, remains poorly understood in prostate cancer (PCa). Herein, we report that PCa growth mice macrophage-specific Ubc9 deficiency is substantially suppressed compared wild-type littermates, an effect partially ascribed to augmented CD8+ T cell response. Biochemical and molecular analyses revealed signal transducer activator transcription 4 (STAT4) a crucial...
Prospective randomized comparison of intermediate-term outcomes patients with small renal tumors who were treated partial nephrectomy (PN) or microwave ablation.Of 102 selected solitary had prospectively completed at least 2 years follow-up since December 2004, randomizedly, 54 either open (19) laparoscopic (35) PN and 48 (28) (20) ablation. Patient tumor characteristics, surgical data, complications, histologic oncologic functional data the two approaches compared.Patients in ablation group...
Summary Excessive production of reactive oxygen species (ROS) by an overactive nicotinamide adenine dinucleotide phosphate (NADPH) oxidase system in penile tissue is important mechanism erectile dysfunction (ED). S ‐allyl cysteine (SAC), a bioactive component derived from garlic, was recently reported to exert versatile antioxidant properties. We hypothesized that SAC would be able resolve diabetes‐related ED reducing ROS generation, and designed this study investigate possibility as well...
Previous studies report that miR-1-3p, a member of the microRNA-1 family (miR-1), and functions as tumor suppressor in several different cancers. However, little is known regarding biological role intrinsic regulatory mechanisms miR-1-3p prostate cancer (PCa). In this study, expression levels were first examined PCa cell lines tissues by RT-qPCR bioinformatics. The vitro vivo functional effect was further. A luciferase reporter assay conducted to confirm target associations. We found...
Summary Adipose‐derived stem cells ( ADSC s) have recently been considered as a promising therapy for erectile dysfunction ED ). However, the mechanism of ‐based is unclear. Insulin‐like growth factor‐1 IGF ‐1), basic fibroblast factor bFGF ), and vascular endothelial VEGF ) secreted by s were assessed in vitro. Sixteen 24‐month‐old male Sprague–Dawley rats used comparative analysis 2‐week treatment with labeled or PBS . Eight additional 5‐month‐old young rat group. At 2 weeks...
Background. Redox plays an essential role in the pathogeneses and progression of tumors, which could be regulated by long noncoding RNA (lncRNA). We aimed to develop verify a novel redox-related lncRNA-based prognostic signature for clear cell renal carcinoma (ccRCC). Materials Methods. A total 530 ccRCC patients from The Cancer Genome Atlas (TCGA) were included this study. All samples randomly split into training test group at 1 : ratio. Then, we screened differentially expressed lncRNAs...
Background Frontline health professionals are a COVID-19-susceptible population during the outbreak of COVID-19, but prophylactic drugs against SARS-CoV-2 infection to be explored. Method diagnosed with COVID-19 before February 9, 2020 in Tongji Hospital, Wuhan, China and same amount controls uninfected group were included this study. Clinical laboratory data collected standardised forms. Results A total 164 subjects study, 82 cases infected group, median age 37 years, including 63 males 101...
Kidney renal clear cell carcinoma (KIRC) has high morbidity and gradually increased in recent years, the rate of progression once relapsed is high. At present, owing to lack effective prognosis predicted markers post-recurrence drug selection guidelines, KIRC patients greatly affected. Necroptosis a regulated form necrosis way that independent caspase. Induced necroptosis considered an strategy chemotherapy targeted drugs, it can also be used improve efficacy immunotherapy. Herein, we...