A5075122118- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Circular RNAs in diseases
- RNA modifications and cancer
- Bladder and Urothelial Cancer Treatments
- Ferroptosis and cancer prognosis
- Renal cell carcinoma treatment
- Urinary and Genital Oncology Studies
- Peptidase Inhibition and Analysis
- Ubiquitin and proteasome pathways
- Lung Cancer Research Studies
- Urological Disorders and Treatments
- Renal and related cancers
- Endoplasmic Reticulum Stress and Disease
- Epigenetics and DNA Methylation
- Esophageal Cancer Research and Treatment
- Cancer, Hypoxia, and Metabolism
- Lung Cancer Treatments and Mutations
- Escherichia coli research studies
- Viral gastroenteritis research and epidemiology
- RNA Interference and Gene Delivery
- Neuroendocrine Tumor Research Advances
- RNA Research and Splicing
- Cancer Genomics and Diagnostics
- Kidney Stones and Urolithiasis Treatments
Second Hospital of Anhui Medical University
2022-2025
Anhui Medical University
2022-2025
Peking University Shenzhen Hospital
2016-2024
Huazhong University of Science and Technology
2015-2024
Tongji Hospital
2012-2024
Chinese PLA General Hospital
2011-2024
Union Hospital
2005-2024
State Key Laboratory of Information Engineering in Surveying Mapping and Remote Sensing
2021-2024
PLA Academy of Military Science
2024
Chinese People's Liberation Army
2024
Abstract Objectives Coronavirus disease 2019 (COVID‐19) is rapidly spreading worldwide. Lianhua Qingwen capsule (LQC) has shown therapeutic effects in patients with COVID‐19. This study aimed to discover its molecular mechanism and provide potential drug targets. Materials Methods An LQC target COVID‐19–related gene set was established using the Traditional Chinese Medicine Systems Pharmacology database seven disease‐gene databases. Gene ontology (GO), Kyoto Encyclopedia of Genes Genomes...
Reciprocal cellular crosstalk within the tumour microenvironment (TME) actively participates in progression. The anterior gradient-2 (AGR2) can be secreted to extracellular compartments and contribute colorectal cancer (CRC) metastasis. We investigated source for AGR2 TME underlying mechanisms mediating AGR2's effects.Tissue microarray, tissues, blood samples tumour-associated neutrophils (TANs) from patients with CRC were isolated phenotypical functional analyses. role of TAN-secreted was...
Abstract Clear cell renal carcinoma (ccRCC) is a complex disease with remarkable immune and metabolic heterogeneity. Here we perform genomic, transcriptomic, proteomic, metabolomic spatial transcriptomic analyses on 100 patients ccRCC from the Tongji Hospital RCC (TJ-RCC) cohort. Our analysis identifies four subtypes including De-clear differentiated (DCCD)-ccRCC, subtype distinctive features. DCCD cancer cells are characterized by fewer lipid droplets, reduced activity, enhanced nutrient...
Previous studies report that miR-1-3p, a member of the microRNA-1 family (miR-1), and functions as tumor suppressor in several different cancers. However, little is known regarding biological role intrinsic regulatory mechanisms miR-1-3p prostate cancer (PCa). In this study, expression levels were first examined PCa cell lines tissues by RT-qPCR bioinformatics. The vitro vivo functional effect was further. A luciferase reporter assay conducted to confirm target associations. We found...
Kidney renal clear cell carcinoma (KIRC) has high morbidity and gradually increased in recent years, the rate of progression once relapsed is high. At present, owing to lack effective prognosis predicted markers post-recurrence drug selection guidelines, KIRC patients greatly affected. Necroptosis a regulated form necrosis way that independent caspase. Induced necroptosis considered an strategy chemotherapy targeted drugs, it can also be used improve efficacy immunotherapy. Herein, we...
Background: Tumor-associated macrophages (TAMs) and dysregulated tumor epigenetics contribute to hepatocellular carcinoma (HCC) progression. However, the mechanistic interactions between TAMs remain poorly understood. Methods: Immunohistochemistry multiplexed fluorescence staining were performed evaluate correlation numbers UHRF1 expression in human HCC tissues. PGE2 neutralizing antibody COX-2 inhibitor used analyze regulation of isolated from tissues on expression. Multiple microRNA...
We have previously reported that synthetic dsRNA can activate p21 expression by targeting the promoter, thereby suppressing proliferation of human bladder cancer cells. As complementarity between and its target sequences is necessary for RNA activation, miRNAs may also trigger through same mechanism. Here, levels three (miR‐370, miR‐1180 miR‐1236) decreased in tissues compared to healthy controls these mRNAs positively correlated with mRNA levels. The induced nuclear p21‐promoter binding....
Several recent reports have demonstrated that small activating dsRNA [double-stranded RNA; saRNA (small dsRNA)] complementary to promoter regions can up-regulate gene expression in mammalian cells, a phenomenon termed RNAa (RNA activation). However, the mechanism of remains obscure with regard what is target molecule for promoter-targeted and are proteins involved this process. p21Waf1/Cip1 (p21) [CDKN1A (cyclin-dependent kinase inhibitor 1A)], an important tumour suppressor gene, among...
Objective Dual-energy CT (DECT) detects and quantifies monosodium urate (MSU) crystal deposition with high precision. This DECT study assessed in patients gout treated stable-dose allopurinol, investigated potential clinical determinants for deposition. Methods Patients allopurinol ≥300 mg daily at least 3 months were prospectively recruited from the USA New Zealand, using monitored enrolment to include approximately 25% palpable tophi 50% serum (sUA) levels <6.0 mg/dL (<357µmol/L)....
Objective: This study aimed to develop and validate a simple-to-use nomogram for early hepatocellular carcinoma (HCC) patients undergoing preoperative consultation doctors conducting postoperative evaluation. Methods: A total of 2, 225 HCC confirmed with stage I or II were selected from the Surveillance, Epidemiology, End Results database between January 2010 December 2015. The randomly divided into two groups: training group (N=1557) validation (N=668). Univariate multivariate hazards...
Background Anterior gradient homolog 2 (AGR2) is a functional protein with critical roles in diverse range of biological systems, including vertebrate tissue development, inflammatory injury responses, and cancer progression. Clinical studies have shown that the AGR2 overexpressed wide human cancers, carcinomas esophagus, pancreas, breast, prostate, lung, making as potential biomarker. However, general biochemical functions cells remain undefined, signaling mechanisms drive to inhibit p53...