A5040827556- Hippo pathway signaling and YAP/TAZ
- Liver Disease Diagnosis and Treatment
- Bladder and Urothelial Cancer Treatments
- Gastric Cancer Management and Outcomes
- Liver physiology and pathology
- Liver Disease and Transplantation
- Evaluation and Optimization Models
- Cancer-related molecular mechanisms research
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Circular RNAs in diseases
- Lipid metabolism and biosynthesis
- Cancer and Skin Lesions
- MicroRNA in disease regulation
- Hepatitis B Virus Studies
- Extracellular vesicles in disease
- Nanoplatforms for cancer theranostics
- Nonmelanoma Skin Cancer Studies
- RNA modifications and cancer
- Metastasis and carcinoma case studies
- Ubiquitin and proteasome pathways
- Urinary Tract Infections Management
- Wnt/β-catenin signaling in development and cancer
- Angiogenesis and VEGF in Cancer
- Inflammatory Biomarkers in Disease Prognosis
- Hedgehog Signaling Pathway Studies
Affiliated Hospital of North Sichuan Medical College
2025
Second Xiangya Hospital of Central South University
2015-2024
Central South University
2013-2024
Central Hospital of Wuhan
2015-2023
Huazhong University of Science and Technology
2017-2023
Development Research Center
2021
Yanshan University
2010-2021
First Affiliated Hospital of Fujian Medical University
2019
Fujian Medical University
2019
First Affiliated Hospital of Xi'an Jiaotong University
2018
Abstract Pro-inflammatory M1 macrophages, via activating hepatic stellate cells, contribute to liver fibrosis. In this study, we examined the mechanism and significance of a signaling axis, METTL3/MALAT1/PTBP1/USP8/TAK1, in regulating pyroptosis polarization macrophages. Liver fibrosis model was established vivo by CCl 4 treatment; induced vitro treating macrophages with lipopolysaccharide or interferon γ. Expressions METTL3, MALAT1, PTBP1, USP8, TAK1 were measured RT-PCR and/or Western blot...
Human bladder cancer (BCa) is one of the worldwide cancers in men and women populations, with etiology mechanism unknown. In our study, we constructed a weighted gene co-expression network to identify modules associated progression BCa (n = 93). significant module (R2 0.48), total 103 hub genes were identified, 4 them nodes protein-protein interaction as well. validation, COL3A1 showed higher correlation disease than any other test set (p < 0.001). Functional pathway enrichment analysis...
Background: To evaluate the pattern and prevalence trends of liver cirrhosis caused by specific etiologies.Results: Globally, number prevalent cases increased 74.53% from 1990 to 2017.The ASR 0.75 per year.The most pronounced increases were found in middle-high high socio-demographic index (SDI) regions, especially Caribbean Latin America.Among etiologies, non-alcoholic steatohepatitis (NASH) related accounted for 59.46% cases.The 1.74 year, increase was observed all 5 SDI regions.In...
We propose an image-based approach for virtual clothes fitting, in which a user moves freely front of mirror (i.e., video screen) that displays the wearing superimposed garment. The motions and deformations garment are synthesized by tracking user's skeleton utilizing corresponding clips actual worn model. Our system overcomes challenges generating convincing animation. With our technique, we developed real-time using Microsoft Kinect camera demonstrates effective fitting results with variety types.
Abstract Hepatic fibrosis (HF) is caused by chronic hepatic injury and characterized stellate cells (HSCs) activation. Studies focusing on the function of exosomes derived from macrophages in HF progression are limited. This study aims to identify roles exosomal NEAT1 underlying mechanisms. Our studies showed that METTL3 targeted enhanced expression macrophages. Exosomal originating LPS-treated promoted HSCs proliferation migration, induced fibrotic proteins including collagen I, α-SMA,...
<title>Abstract</title> Aims To evaluate the safety profile of Imatinib using FAERS database, identifying both documented and undocumented adverse events. Methods data Q1 2004 to 2024 were analyzed via disproportionality analysis (ROR, PRR, BCPNN, EBGM) quantify drug-AE associations. Results A total 56,364 patients (170,659 AE occurrences) included. exhibited expected AEs (e.g., nausea, diarrhea) consistent with labels, alongside novel signals such as pubertal failure (ROR = 452.74), large...
Abstract Liver cancer is the sixth most common and third leading cause of cancer‐related death globally. Despite efforts being made in last two decades diagnosis treatment, 5‐year survival rate liver remains extremely low. TRIM21 participates metabolism, glycolysis, immunity, chemosensitivity metastasis by targeting various substrates for ubiquitination. serves as a prognosis marker human hepatocellular carcinoma (HCC), but mechanism which regulates HCC tumorigenesis progression elusive. In...
Abstract YAP-TEAD complex plays an important role in tumorigenesis. 5-HT is proved to upregulate YAP expression by our previous study and VGLL4 found compete with for binding TEAD several of cancers. Here, we investigated whether could affect progression prognosis hepatocellular carcinoma (HCC) patients regulate YAP/VGLL4 balance. We that ratio were higher HCC closely related poor prognosis. Furthermore, level, tumor size as independent risk factors study. Based on the factors, nomogram was...
Accumulated evidence has indicated that micro (mi)RNAs play vital roles in the occurrence and development of human muscle invasive bladder cancer (MIBC), however, little is known about miRNAs' regulatory networks. In present study, authors aimed to use bioinformatics analysis identify key miRNAs potential target genes, as well studying underlying mechanisms for MIBC. They collected several MIBC tissues generate a miRNA expression by microarray comparing with normal tissues, identifying 104...
Aiming at the problem of high cost in cold chain logistics fresh products home-delivery supermarket new retail era, paper constructs model Location Inventory Routing Problem (LIRP) optimization Satellite Warehouse mode view customer satisfaction with broken line soft time windows. The minimizes total system through location allocation, inventory optimization, determination distribution service relationship between and customer, constraint penalty cost. Then, designed an improved ant colony...
Heat shock protein B8 (HSPB8) has been recently discovered to be participated in the regulation of tumor progression. However, function HSPB8 intrahepatic cholangiocarcinoma (ICC) not yet elucidated. This study studied ICC progression.ICC patients (n = 150) were enrolled. The relationship between clinicopathological characteristics and expression was analyzed. RBE cells transfected treated by 3-MA. morphology observed under a transmission electron microscope. Cell counting kit-8 assay, wound...
Post-pancreaticoduodenectomy hemorrhage is a life-threatening complication that occurs in 2-10% of patients. The most common location for post-pancreaticoduodenectomy the gastroduodenal artery stump. Nonetheless, unusual sources hemorrhage, which are hard to locate, exist. Here, we report rare postoperative after robotic-assisted pancreatoduodenectomy pancreatic head cancer. A 67-year-old man presenting with appetite loss, general fatigue and painless jaundice was admitted our ward. patient...
Abstract Purpose To investigate the effect of grape seed-derived proanthocyanidin B2 (GSPB2) pretreatment on acute renal ischemia–reperfusion injury model mice. Methods 50 mice were divided into 5 groups: Sham group: treated with right nephrectomy. GSPB2 was injected intraperitoneally 45 min before IRI kidney resected and left arteriovenous vessel blocked for min. + established. BRU brusatol (BRU) Creatinine urea nitrogen detected, morphology pathological changes each group detected by HE...