A5101426480- Cancer-related molecular mechanisms research
- RNA modifications and cancer
- MicroRNA in disease regulation
- Natural product bioactivities and synthesis
- Flavonoids in Medical Research
- Berberine and alkaloids research
- Epigenetics and DNA Methylation
- Biological Activity of Diterpenoids and Biflavonoids
- Circular RNAs in diseases
- Alkaloids: synthesis and pharmacology
- Cancer Cells and Metastasis
- Pancreatic and Hepatic Oncology Research
- Phytochemistry and Biological Activities
- Liver physiology and pathology
- Cell death mechanisms and regulation
- Bioactive Natural Diterpenoids Research
- Telomeres, Telomerase, and Senescence
- Plant-based Medicinal Research
- TGF-β signaling in diseases
- Botanical Research and Chemistry
- Autophagy in Disease and Therapy
- Pluripotent Stem Cells Research
- Metal complexes synthesis and properties
- Cardiac Fibrosis and Remodeling
- Ferroptosis and cancer prognosis
Second Xiangya Hospital of Central South University
2018-2025
Central South University
2012-2025
Shanghai First Maternity and Infant Hospital
2018-2022
Heilongjiang Bayi Agricultural University
2022
Third Affiliated Hospital of Sun Yat-sen University
2020-2021
Sun Yat-sen University
2020-2021
Shenyang Pharmaceutical University
2015-2018
Tongji University
2016
Tongji Hospital
2016
Xiangya Hospital Central South University
2012-2015
Pancreatic ductal adenocarcinoma (PDAC) remains a challenging malignancy due to distant metastasis. RELA, major component of the NF-κB pathway, could serve as an oncogene through activating proliferation or migration-related gene expression, including NEAT1, well-known oncogenic long noncoding RNA. In current study, expression and function RELA NEAT1 in PDAC were examined. The potential upstream regulatory microRNAs screened verified for their correlation with NEAT1. selected miR-302a-3p...
Nowadays, pancreatic cancer (PC) remains the most lethal tumor, partially due to invasive and treatment-resistant phenotype induced by extent of hypoxic stress within tumor tissue. According previous studies, miR-142/HIF-1α miR-133a/EGFR could modulate PC cell proliferation under normoxic conditions, respectively. In present study, FEZF1-AS1, a recently described oncogenic long noncoding RNA, was predicted target both miR-142 miR-133a; thus, we hypothesized that FEZF1-AS1 might affect...
Colorectal cancer (CRC) is a commonly occurring tumour with poor prognosis.Autophagy-related long non-coding RNAs (lncRNAs) have received much attention as biomarkers for prognosis and diagnosis.However, few studies focused on their prognostic predictive value specifically in CRC.This research aimed to construct robust autophagy-related lncRNA signature CRC.Autophagy-related lncRNAs from The Cancer Genome Atlas database were screened using univariate Cox, LASSO, multivariate Cox regression...
Pancreatic cancer has one of the highest mortality rates among malignant tumors and is characterized by rapid invasion, early metastasis chemoresistance. X‑linked inhibitor apoptosis (XIAP) survivin are two most important members IAP family. Previous studies have shown that XIAP were overexpressed in pancreatic closely associated with cell proliferation chemoresistance to gemcitabine. In present study, stable inhibition Panc‑1 cells was performed using lentivirus‑carried short hairpin RNAs....
Inspired by the intriguing structures and bioactivities of dimeric alkaloids, 11 new thalifaberine-type aporphine-benzylisoquinoline thalicultratines A–K, a tetrahydroprotoberberine-aporphine alkaloid, thalicultratine L, five known ones were isolated from roots Thalictrum cultratum. Their defined on basis NMR HRESIMS data. The antiproliferative activities compounds 1–17 evaluated against human leukemia HL-60 prostate cancer PC-3 cells. Most alkaloids showed potent cytotoxicity selected...
A new cytotoxic dimeric naphthopyrone, aurasperone H (1), together with eight related known polyketides (2-9) was isolated from a marine-derived fungus Aspergillus niger 2HL-M-8. The structure of compound 1 elucidated on the basis its spectroscopic data (1D, 2D NMR and CD). Compound exhibited moderate inhibitory activity against human lung adenocarcinoma A549 leukaemia HL-60 cell lines. 5 displayed significant in vitro antiproliferative line an IC50 value 0.8 μM.
MicroRNAs (miRNAs) represent a class of small non‑coding RNAs regulating gene expression by inducing the degradation RNA or interfering with translation. Aberrant miRNA has been described in several types cancer humans. In present study, it was demonstrated that miR‑145 is downregulated pancreatic tissues and Panc‑1 cell line. Restoration inhibited proliferation, invasion migration cells. Neural precursor expressed, developmentally down‑regulated 9 (NEDD9) identified as novel potential...
Abstract Long noncoding RNAs (lncRNAs) are emerging as critical regulators in tumor initiation and progression. However, the biological mechanisms potential clinical application of lncRNA NORAD endometrial cancer (EC) remain unknown. Herein, we identified underwent promoter hypermethylation-associated downregulation EC. Epigenetic inactivation was correlated with EC progression (FIGO stage) poor outcome. Overexpression significantly inhibited cell growth promoted apoptosis cells. Mechanistic...
Individuals with diffuse large B cell lymphoma (DLBCL) infected hepatitis virus (HBV) have worse chemotherapy efficacy and poorer outcomes. It is still unclear whether long noncoding RNAs (lncRNAs) serve as prognostic therapeutic targets in the resistance of individuals DLBCL HBV infection. Here we found that core component (HBX) directly upregulated expression lncNBAT1, which was closely associated outcomes HBV-infected DLBCL. Upregulation lncNBAT1 reduced sensitivity cells to...
Endometrial cancer (EC) is the second leading type of among women, and its progression dependent on several factors. The aim present study was to examine effect solute carrier organic anion transporter family member 4C1 (SLCO4C1) human EC determine underlying molecular mechanism. A total 57 differentially expressed genes associated with advanced stage survival were identified in Cancer Genome Atlas database. In addition, gene ontology analysis indicated that SLCO4C1 highly cell...
In this study, a comprehensive analysis of TNF family members in colorectal cancer (CRC) was conducted and family-based signature (TFS) generated to predict prognosis immunotherapy response. Using the expression data 516 CRC patients from The Cancer Genome Atlas (TCGA) database, were screened construct TFS by using univariate Cox proportional hazards regression least absolute shrinkage selection operator- (LASSO-) method. then validated meta-Gene Expression Omnibus (GEO) cohort ( <a:math...
Abstract The potential for tumor occurrence triggered by cancer stem cells (CSCs) has emerged as a significant challenge human colorectal therapy. However, the underlying mechanism of CSC development remains controversial. Our study provided evidence that bulk could dedifferentiate to CSCs and reacquire CSC‐like phenotypes if cultured in presence extracellular matrix reagents, such Matrigel fibrin gels. In these 3D gels, CD133 − can regain tumorigenic stem‐like phenotypes. Mechanistically,...
Abstract Background Enhancer RNAs (eRNAs) are demonstrated to be closely associated with tumourigenesis and cancer progression. However, the role of eRNAs in lung adenocarcinoma (LUAD) remains largely unclear. Thus, a comprehensive analysis was constructed identify key eRNAs, explore clinical utility identified LUAD. Methods First, LUAD expression profile data from Cancer Genome Atlas (TCGA) dataset eRNA-relevant information were integrated for Kaplan-Meier survival Spearman’s correlation...
A series of nine enmein-type ent-kaurane diterpenoid and furoxan-based nitric oxide (NO) donor hybrids (10a-i) were designed synthesized from commercially available oridonin (1). These evaluated for their antiproliferative activity against Bel-7402, K562, MGC-803, CaEs-17 human cancer cell lines L-02 normal liver cells. The tumor cells was stronger than the lead compound 1 parent molecule 9 in most cases. Especially, 10f showed strongest hepatocarcinoma Bel-7402 line with an IC50 0.81 μM...
Telomere maintenance is critical for chromosome stability. Here we report that periodic tryptophan protein 1 (PWP1) involved in regulating telomere length homeostasis. Pwp1 appears to be essential mouse development and embryonic stem cell (ESC) survival, as homozygous Pwp1-knockout mice ESCs have never been obtained. Heterozygous had shorter telomeres decreased reproductive capacity. depletion induced rapid shortening accompanied by reduced shelterin complex increased DNA damage telomeric...
The authors aimed to investigate the epidemiology of morning blood pressure (BP) surge (MBPS) in chronic kidney disease (CKD) patients, and interaction effect between MBPS dipping status for target organ damage (TOD). A total 823 non-dialysis CKD patients were enrolled this cross-sectional study. Subjects grouped according their systolic BP status, assessed by 24-hour ambulatory monitoring. Patients with elevated had highest quartile (≥26.89 mm Hg). Non-dipping pattern was defined as a...
Gastric cancer is among the most frequently occurring gastrointestinal malignancies with a high mortality rate worldwide. Long non-coding RNAs (lncRNAs) are defined as core regulators in occurrence and progression of multiple cancers, including gastric carcinoma. Mounting evidence has indicated that NR2F2-AS1 can inhibit several malignant tumors. However, function potential mechanism remain unclear. In current study, we found was weakly expressed cells comparison normal cells. The study...
Accumulating evidence has indicated that dysregulation of microRNAs (miRNAs) contributes to the tumorigenesis prostate cancer (PCa). Nevertheless, role miR-593-3p in development PCa remains unclear. The objective this study was investigate and mechanisms cells.RT-PCR used detect expression levels miR-593-3p. CCK-8, colony formation, spheroid formation transwell assays were performed examine proliferation, migration invasion C4-2, DU145 RWPE-1 cells. And then, transcriptome sequencing,...
During reprogramming, telomere re-elongation is important for pluripotency acquisition and ensures the high quality of induced pluripotent stem cells (iPSCs), but regulatory mechanism remains largely unknown. Our study showed that fully reprogrammed mature iPSCs or mouse embryonic expressed higher levels miR-590-3p miR-590-5p than pre-iPSCs. Ectopic expression either in pre-iPSCs improved elongation pluripotency. Activin receptor II A (Acvr2a) downstream target mediates function miR-590....