A5100692462- Colorectal Cancer Surgical Treatments
- Radiomics and Machine Learning in Medical Imaging
- Cancer, Hypoxia, and Metabolism
- Sirtuins and Resveratrol in Medicine
- High Altitude and Hypoxia
- RNA modifications and cancer
- Alzheimer's disease research and treatments
- Lipid Membrane Structure and Behavior
- Analytical Chemistry and Sensors
- Ferroptosis and cancer prognosis
- Cell Adhesion Molecules Research
- Neuroscience and Neuropharmacology Research
- Cancer Cells and Metastasis
- Medical Imaging and Analysis
- Colorectal Cancer Treatments and Studies
- MicroRNA in disease regulation
- Caveolin-1 and cellular processes
- Colorectal and Anal Carcinomas
- Cancer-related molecular mechanisms research
- Erythrocyte Function and Pathophysiology
- Monoclonal and Polyclonal Antibodies Research
- Advanced Fluorescence Microscopy Techniques
- Biochemical effects in animals
- Cancer-related cognitive impairment studies
- Toxin Mechanisms and Immunotoxins
Hebei Medical University
2014-2025
Fourth Hospital of Hebei Medical University
2013-2025
Third Hospital of Hebei Medical University
2019-2023
Yunnan Agricultural University
2023
Second Hospital of Hebei Medical University
2023
Wuhan Academy of Agricultural Sciences
2020-2021
Qingdao Agricultural University
2020
Zhongda Hospital Southeast University
2019
Shanxi Datong University
2019
Shanghai First Maternity and Infant Hospital
2018
MRI is the gold standard for confirming a pelvic lymph node metastasis diagnosis. Traditionally, medical radiologists have analyzed image features of regional nodes to make diagnostic decisions based on their subjective experience; this diagnosis lacks objectivity and accuracy. This study trained faster region-based convolutional neural network (Faster R-CNN) with 28,080 images metastasis, allowing Faster R-CNN read those diagnoses. For clinical verification, 414 cases rectal cancer at...
Abstract Objective Increasing evidence has revealed that mechanical stress and elevated signals promote malignant tumor transformation metastasis. This study aimed to explore the function of mechanically activated ion-channel Piezo1 in colon cancer metastasis its potential regulatory mechanism. Methods First, we examined expression levels mitochondrial calcium uniporter (MCU) both tissues assessed prognostic value MCU a cohort ( n = 110). Second, functional assays were performed investigate...
Extracellular vesicles (EVs), known as cell-derived membranous structures harboring a variety of biomolecules, have been widely used in liquid biopsy. Due to the complex biological composition plasma, plasma RNA omics analysis (RNomics) is easily affected, thus it necessary select an optimal strategy from exiting methods according performance for intended application.In this study, four different strategies EVs isolation were performed and compared (i.e. ultracentrifugation (UC), size...
The interleukin-11 receptor alpha (IL-11Ralpha) is a functional target in bone metastasis. However, its role primary tumors has not been established. As such, here, we evaluated IL-11Ralpha as candidate and metastatic human osteosarcoma. First, an orthotopic mouse model, showed that protein markedly expressed osseus pulmonary osteosarcoma but absent from control normal tibia lung. Moreover, systemic administration of IL-11Ralpha-targeting phage displaying the cyclic nonapeptide CGRRAGGSC...
Long noncoding RNAs (lncRNAs) participate in and regulate the biological process of colorectal cancer (CRC) progression. Our previous research identified differentially expressed lncRNAs 10 CRC tissues matched nontumor by next-generation sequencing (NGS). In this study, we an lncRNA, FEZF1 antisense RNA 1 (FEZF1-AS1), further explored its function mechanism CRC. We verified that FEZF1-AS1 is highly cell lines. Through functional experiments, found reduced levels significantly suppressed...
Abstract Transcobalamin (TCN1) is a vitamin B12 (cobalamin)-binding protein that regulates cobalamin homeostasis. Recent studies and bioinformatic analyses have found TCN1 highly expressed in cancer tissues associated with tumour aggressiveness poor prognosis. The present study aimed to detect as novel biomarker for prognosis chemosensitivity of colon cancer. Next-generation sequencing showed was one several upregulated mRNAs cancer, which verified by further bioinformatics analyses. Western...
Abstract Peritoneal metastasis is a common form of among advanced gastric cancer patients. In this study, we reported the identification LIM domain kinase 1 (LIMK1) as promoter peritoneal metastasis, and its potential to be therapeutic target dabrafenib (DAB). Using transcriptomic sequencing paired primary tumors, normal tissues, first unveiled that LIMK1 selectively up-regulated in metastatic tumors. Increased was validated by immunohistochemistry analysis an independent patient cohort....
Context Paclitaxel (PTX) leads to chemotherapy brain (chemo-brain) which is characterised by cognitive impairment. It has been reported that necroptosis associated with impairment in some neurodegenerative diseases, but it not clear whether related the development of chemo-brain.Objective To investigate role and changes PTX-induced impairment.Materials methods C57bl/6n mice were randomly divided into five groups: control, vehicle, different concentrations PTX (6, 8, 10 mg/kg). Two additional...
TPS315 Background: CRT followed by total mesorectal excision (TME) is the standard care for patients with locally advanced low rectal cancer (≤ 5cm from anal margin). However, TME may lead to permanent colostomy and severely impact quality of life. Organ preservation is, therefore, a critical unmet need these patients. The proportion achieving clinical complete response (cCR) after relatively low, literature reporting around 20%. Total neoadjuvant therapy (TNT) has been investigated increase...
150 Background: It has been found that radiotherapy possess synergistic anticancer effect with immune checkpoint inhibitors (ICIs). Therefore, this phase II randomized clinical trial (RCT) (ClinicalTrials.gov identifier: NCT05086627) aimed to evaluate the efficacy and safety of SCRT followed by CAPOX tislelizumab in patients LARC. Methods: Patients initially diagnosed rectal adenocarcinoma cT1-2N+M0 or cT3-4NanyM0 were recruited, randomly assigned receive (25Gy/5f), four cycles combined...
Previous studies have shown that ovariectomy (OVX) induces lacrimal gland regression and androgens are implicated. This study explored the effects of estrogen androgen on tear secretion matrix metalloproteinase 2 (MMP-2) expression in glands ovariectomized rats.Sixty-four adult female Wistar rats were randomly divided into three groups (control, sham operated, OVX). Bilateral OVX was performed group. After 5 months, group further six subgroups receiving topical ophthalmic or systemic...
An efficient surface enhanced Raman scattering (SERS) substrate of graphene-isolated Ag nanoparticle (G/AgNP) has been developed by using excimer laser to ablate the ordered pyrolytic graphite in high vacuum onto nanoparticles.
Right hemicolectomy is the standard treatment for right-sided colon cancer. There variation in technical aspects of performing right as well short-term outcomes. It therefore necessary to explore best clinical practice following expert centres.
Abstract Dual oxidase 2 (DUOX2) is an important regulatory protein in the organic process of thyroid hormone iodine. Mounting evidence suggests that DUOX2 plays a crucial role occurrence and development cancers. However, function mechanism colorectal cancer (CRC) have not been fully clarified. In present study, relationship between expression clinicopathological features prognosis CRC patients was analyzed. Furthermore, effects on proliferation invasion vitro vivo were examined....
Colorectal cancer (CRC) is one of the most common cancers worldwide, and approximately one-third CRC patients present with metastatic disease. Periplocymarin (PPM), a cardiac glycoside isolated from Periploca sepium, latent anticancer compound. The purpose this study was to explore effect PPM on cells. cells were treated cell viability evaluated by CCK-8 assay. Flow cytometry TUNEL staining performed assess cycle apoptosis. Quantitative proteomics has been used check proteins differentially...
Chronic myeloid leukemia (CML) is a hematopoietic stem cell disease caused by the oncoprotein BCR-ABL, which exhibits constitutive tyrosine kinase activity. Imatinib mesylate (IM), an inhibitor of activity has been used as first-line therapy for CML. However, IM less effective in accelerated phase and blastic phases CML certain patients develop resistance due to mutation amplification BCR-ABL gene. Fangchinoline, important chemical constituent from dried roots Stephaniae tetrandrae S. Moore,...
The internal microbial diversity and small molecular metabolites of Nuodeng ham in different processing years (the first, second third year sample) were analyzed by high-throughput sequencing technology gas chromatography-time flight mass spectrography (GC-TOF-MS) to study the effects microorganisms on quality years. results showed that dominant bacteria phyla <em>Proteobacteria </em>and <em>Firmicutes</em>, fungi <em>Ascomycota <em>Basidiomycota</em>, while <em>Staphylococcus</em>...
Gastric cancer (GC) is one of the major public health problems worldwide with high morbidity and mortality. Nowadays, traditional medicine may hold promise for treatment cancers. Gossypol-acetic acid (GAA) a male contraceptive agent that shows anti-tumor effects on multiple types However, whether GAA would inhibit progression GC remained unclear.The potential targets were predicted by Pharmmapper software GC-related genes obtained from GeneCard database. The "GC-targets-GAA" network was...