A5101665486- Advanced Photocatalysis Techniques
- RNA modifications and cancer
- Copper-based nanomaterials and applications
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- Cell death mechanisms and regulation
- Nanoparticle-Based Drug Delivery
- Advanced biosensing and bioanalysis techniques
- Cancer, Hypoxia, and Metabolism
- Speech and dialogue systems
- Water Quality Monitoring and Analysis
- Imbalanced Data Classification Techniques
- Cancer Mechanisms and Therapy
- Cancer Research and Treatments
- Gas Sensing Nanomaterials and Sensors
- Cancer, Lipids, and Metabolism
- Biosensors and Analytical Detection
- Nanoplatforms for cancer theranostics
- Marine and coastal ecosystems
- Natural Language Processing Techniques
- interferon and immune responses
- CRISPR and Genetic Engineering
- Mechanisms of cancer metastasis
- Characterization and Applications of Magnetic Nanoparticles
- Artificial Intelligence in Law
Guangdong University of Technology
2024-2025
University of Electronic Science and Technology of China
2022-2025
Zhongshan People's Hospital
2024
Hunan University
2019-2024
State Key Laboratory of Chemobiosensing and Chemometrics
2019-2024
Shandong University of Technology
2023
Sun Yat-sen University
2015-2022
Hefei University
2022
Henan University of Urban Construction
2021-2022
State Key Joint Laboratory of Environment Simulation and Pollution Control
2022
Bufalin is the active ingredient of Chinese medicine Chan Su, and it has been reported that bufalin induces apoptosis in some human leukemia solid cancer cell lines. The exact mechanism bufalin-induced is, however, still not clear. In this study, we demonstrated inhibited proliferation gastric MGC803 cells a dose-dependent time-dependent manner. At low concentration (20 nmol/l), induced M-phase cycle arrest, whereas at high (80 nmol/l) cells. increased Bax/Bcl-2 ratio activated caspase-3...
MRI is the gold standard for confirming a pelvic lymph node metastasis diagnosis. Traditionally, medical radiologists have analyzed image features of regional nodes to make diagnostic decisions based on their subjective experience; this diagnosis lacks objectivity and accuracy. This study trained faster region-based convolutional neural network (Faster R-CNN) with 28,080 images metastasis, allowing Faster R-CNN read those diagnoses. For clinical verification, 414 cases rectal cancer at...
Background: Extensive studies related to vascular calcification (VC) were conducted in recent years. However, no bibliometric analysis has systematically investigated this topic. Our study aimed determine the hotspots and frontiers of VC research past decade provide a reference for future scientific directions decision-making field. Methods: acquired from Web Science Core Collection. Bibliometric visual analyses performed using CiteSpace, VOSviewer, Microsoft Excel software. Results: A total...
Drug-resistant tuberculosis (TB) is a serious public health problem and threat to global TB prevention control. Streptomycin (STR) the earliest classical anti-TB drug, it drug that generated resistance treatment, which limits its use in treating impedes control efforts. The rapid, economical, highly sensitive detection of STR-resistant may help reduce disease transmission morbimortality. CRISPR/CRISPR-associated protein (Cas) new-generation pathogen method can detect single-nucleotide...
Estuaries are nitrous oxide (N2O) emission hotspots and play an important role in the global N2O budget. However, large spatiotemporal variability of complex estuary environments is challenging for large-scale monitoring budget quantification. This study retrieved water environmental variables associated with cycling based on satellite imagery developed a machine learning model concentration estimations. The was adopted China's Pearl River Estuary to assess dynamics as well annual total...
Surface-enhanced Raman spectroscopy (SERS) tags have the advantages of unique fingerprint vibration spectrum, ultranarrow spectral line widths, and weak photobleaching effect, showing great potential for bioimaging. However, SERS imaging is still hindered further application due to its spontaneous scattering, biomolecular signal interference, long acquisition times. Here, we develop a novel tag core (Au)–shell (N-doped graphene) structure (Au@NGs) with ultrastrong stable (2180 cm–1) in...
The electrochemical two-electron oxygen reduction reaction (2e–1ORR) is a promising route for renewable H2O2 generation as an alternative method to the anthraquinone process. development of efficient and highly selective catalytic materials meaningful challenging subject due strong competition from traditional four-electron (4e–1ORR). Here, we synthesized bismuth titanate (Bi4Ti3O12) nanosheets type new electrocatalyst 2e–1ORR. structure Bi4Ti3O12 characterized by high-resolution...
Cancers frequently develop resistance to paclitaxel but the underlying molecular mechanisms remain be determined. We have investigated proteins that are associated with in human breast cancer MCF-7 cells using proteomic analysis. Paclitaxel resistant (MCF-7/P) were established by escalating concentrations of drug-sensitive (MCF-7/S). The global protein profiles MCF-7/P and MCF-7/S compared two-dimensional gel electrophoresis (2-DE) matrix-assisted laser desorption/ionization time flight mass...
MicroRNAs can be used in the prognosis of malignancies; however, their regulatory mechanisms are unknown, especially pancreatic ductal adenocarcinoma (PDAC). In 120 PDAC specimens, miRNA levels were assessed by quantitative real time polymerase chain reaction (qRT-PCR). Then, role miR-29b-2-5p cell proliferation was evaluated both vitro (Trypan blue staining and cycle analysis two lines SW1990 Capan-2) vivo using a xenograft mouse model. Next, bioinformatics methods, luciferase reporter...
Oral tongue squamous cell carcinoma (OTSCC) is one of the most aggressive forms head and neck/oral cancer (HNOC), a complex disease with extensive genetic epigenetic defects, including microRNA deregulation. Identifying deregulation microRNA-mRNA regulatory modules (MRMs) crucial for understanding role in OTSCC. A comprehensive bioinformatics analysis was performed to identify MRMs HNOC by examining correlation among differentially expressed mRNA profiling datasets integrating 12 different...
Open AccessCCS ChemistryRESEARCH ARTICLE14 Jul 2022A Magnetocatalytic Propelled Cobalt–[email protected] Navigator for Enhanced Tumor Penetration and Theranostics Liang Zhang†, Qian Dong†, Hui Jieqiong Xu, Shen Wang, Lufeng Zhang, Wentao Tang, Zhaoqian Li, Xin Xia, Xinqi Cai, Shengkai Ruizi Peng, Zhengyu Deng, Michael J. Donovan, Long Chen, Zhuo Chen Weihong Tan Zhang† Molecular Science Biomedicine Laboratory (MBL), State Key of Chemo/Biosensing Chemometrics, College Chemistry Chemical...
Abstract Background The gasdermin E gene ( GSDME , also known as DFNA5 ) is mutated in familial aging-related hearing loss. Recent studies have revealed that the expression of suppressed many cancer types; however, little about function head and neck squamous cell carcinoma (HNSCC). Accordingly, aim present study was to evaluate explore its prognostic value HNSCC. Result We used a set bioinformatics tools, including Oncomine, TIMER, TISIDB, cBioPortal, GEPIA, analyze patients with HNSCC from...
Background PRL ‐3 had been found to be involved in tumorigenesis various malignancies. In this study, we investigated the role of development, migration, and invasion salivary adenoid cystic carcinoma ( SACC ). Methods Immunohistochemistry IHC ) was used analyze development prognosis . Then, overexpressed or inhibited expression paired cells migration vitro assays were used. Western blotting detect metastasis‐related protein levels. Results results confirmed that deregulation a frequent...
Surgical treatment of unilateral Wilms tumor (WT) in children is controversial. In this study, we aimed to evaluate the survival and prognosis radical nephrectomy (RN) nephron-sparing surgery (NSS) with WT receiving adjuvant chemotherapy.