A5020632447- Circular RNAs in diseases
- Prostate Cancer Treatment and Research
- MicroRNA in disease regulation
- Advanced Photocatalysis Techniques
- Cancer-related molecular mechanisms research
- RNA Research and Splicing
- Cancer, Hypoxia, and Metabolism
- Copper-based nanomaterials and applications
- Ubiquitin and proteasome pathways
- Gas Sensing Nanomaterials and Sensors
- RNA modifications and cancer
- ZnO doping and properties
- Cancer-related gene regulation
- Perovskite Materials and Applications
- Genetic and Clinical Aspects of Sex Determination and Chromosomal Abnormalities
- RNA and protein synthesis mechanisms
- Biochemical and Molecular Research
- TiO2 Photocatalysis and Solar Cells
- Redox biology and oxidative stress
- Heat shock proteins research
- CAR-T cell therapy research
- Signaling Pathways in Disease
- Cell death mechanisms and regulation
- Diabetes Treatment and Management
- Advanced Nanomaterials in Catalysis
Southern Medical University
2013-2024
Huizhou Central People's Hospital
2015-2024
Zhujiang Hospital
2024
First People's Hospital of Nanning
2024
Hefei University
2021-2023
Guangzhou Medical University
2012-2021
Guangdong Medical College
2021
Guangzhou Eighth People's Hospital
2021
Capital Medical University
2020
Beijing Tian Tan Hospital
2020
Abstract Renal cell carcinoma (RCC) is one of the three major malignant tumors urinary system and originates from proximal tubular epithelial cells. Clear renal (ccRCC) accounts for approximately 80% RCC cases recognized as a metabolic disease driven by genetic mutations epigenetic alterations. Through bioinformatic analysis, we found that FK506 binding protein 10 (FKBP10) may play an essential role in hypoxia glycolysis pathways ccRCC progression. Functionally, FKBP10 promotes proliferation...
Our previous microarray data showed that microRNA-224 (miR-224) was downregulated in human prostate cancer (PCa) tissues compared with adjacent benign tissues. However, the underlying mechanisms by which miR-224 is involved PCa remain unclear. In this study, we identified TRIB1 as a target gene of miR-224. Forced expression suppressed cell proliferation, invasion and migration, promoted apoptosis downregulating TRIB1. Moreover, level negatively correlated downregulation frequently found...
Abstract Background SOX genes play an important role in a number of developmental processes. Potential roles SOXs have been demonstrated various neoplastic tissues as tumor suppressors or promoters depending on status and types. The aim this study was to investigate the involvement progression prognosis human prostate cancer (PCa). Methods gene expression changes PCa compared with non-cancerous detected using microarray, confirmed by real-time quantitative reverse transcriptase-polymerase...
To investigate the mechanism by which peroxiredoxin III (PRDX3) is altered in human prostate cancer (PCa), we used microRNA (miRNA) target prediction program and miRNA microarray to predict identify miR‐23b as a candidate that targets PRDX3. We showed suppresses PRDX3 protein expression DU145 cells under normal hypoxic conditions. Additionally, clinical significance of PCa patients was also confirmed. In conclusion, our data suggest effects progression may be caused regulation function...
To explore the role of microRNA-1266 in colorectal cancer (CRC) and its underlying mechanism.The expression level 48 CRC tissues paracancerous was detected by quantitative Real-time-polymerase chain reaction (qRT-PCR). The relationship between basic characteristics patients analyzed. effect on viability cells cell counting kit-8 (CCK-8) assay. Subsequently, a potential target gene for predicted through bioinformatics. Finally, binding condition verified RNA protein immunoprecipitation (RIP)...
B-cell lymphoma 9 (BCL9), a component of aberrantly activated Wnt signaling, is an important contributing factor to tumor progression. Our previous data indicated that downregulation the suppressor microRNA-30c (miR-30c) was frequent pathogenetic event in prostate cancer (PCa). However, functional link between miR-30c and BCL9/Wnt their clinical pathological significance PCa, have not been well established. The present study demonstrated serves as key negative regulator targeting BCL9...
Our previous study revealed that microRNA (miR) ‑30c represents a potential tumor suppressor gene, the expression of which is associated with decreased oncogenic in prostate cancer (PCa) cell lines. However, functional role and underlying mechanisms miR‑30c PCa remain to be fully elucidated. Reverse transcription‑quantitative polymerase chain reaction immunohistochemical analysis were used detect levels alternative splicing factor/splicing factor 2 (ASF/SF2) tissues. A luciferase reporter...
Previous researchers have demonstrated that microRNA‑505 (miR‑505) is negatively correlated with progression in various malignancies. However, the detailed function and molecular mechanisms of miR‑505 yet to be completely elucidated prostate cancer (PCa). The present study initially identified potential role PCa using vitro experiments, restoration inhibited proliferation, invasion migration, induced cell cycle arrest promoted apoptosis cells. also expression neuron‑glial‑related adhesion...
Metformin is a classic type II diabetes drug which possesses anti-tumor properties for various cancers. However, different cancers do not respond to metformin with the same effectiveness or acquire resistance. Thus, searching vulnerabilities of metformin-resistant prostate cancer promising strategy improve therapeutic efficiency drug. A genome-scale CRISPR-Cas9 activation library search targeting 23,430 genes was conducted identify that confer resistance in cells. Candidate were selected by...
The relationship of osteoporosis and stroke is still not fully clarified. Apart from the well-known risk factors for stroke, bone mineral density (BMD) has gained more interest in recent years.To further elucidate between BMD risk, a prospective cohort study Chinese rural population was conducted.Retrospective analysis family cohort.Our subjects were selected an conducted Anqing, China. All participants underwent questionnaire assessment, clinical examinations laboratory assessments. During...
Chemotherapy has been proven to be an efficient strategy for the treatment of prostate cancer (PC). However, insufficient cellular uptake drugs is biggest challenge PC therapy. Therefore, in order address above concern, we developed tumor-targeted hyaluronic acid-silver nanoparticles (HA-Ag NPs), which acid can specially bind with its receptor CD44 overexpressed on LNCaP cells. HA-Ag NPs have used load paclitaxel (PTX) prepare functionalized silver (HA-Ag-PTX). The average particle size...