A5101421814- Cancer, Hypoxia, and Metabolism
- Peanut Plant Research Studies
- Medical Research and Treatments
- Agricultural pest management studies
- Plant Pathogens and Fungal Diseases
- Healthcare and Venom Research
- CAR-T cell therapy research
- Hematopoietic Stem Cell Transplantation
- Ubiquitin and proteasome pathways
- Adrenal and Paraganglionic Tumors
- Pluripotent Stem Cells Research
- RNA Research and Splicing
- Mitochondrial Function and Pathology
- Nuclear Structure and Function
- Entomopathogenic Microorganisms in Pest Control
- Cancer-related molecular mechanisms research
- T-cell and B-cell Immunology
- Cancer-related gene regulation
- Agricultural economics and policies
- Genomics and Chromatin Dynamics
- Ferroptosis and cancer prognosis
- Epigenetics and DNA Methylation
- Traditional Chinese Medicine Studies
- Prostate Cancer Treatment and Research
- Traditional Chinese Medicine Analysis
Huizhou Central People's Hospital
2020-2024
Guangdong Medical College
2023
Ministry of Agriculture and Rural Affairs
2021
Jiangsu Academy of Agricultural Sciences
2021
Guangzhou Institutes of Biomedicine and Health
2013-2015
Chinese Academy of Sciences
2015
First Affiliated Hospital of Henan University
2015
Taiwan Semiconductor Manufacturing Company (China)
2013
Objective: To identify a specific hypermethylated molecular biomarker for human malignant glioblastoma prognosis. Materials and Methods: Genome-wide methylation profiling was performed on 33 tumors 3 normal samples using the Infinium HumanMethylation450 microarray. Cluster analysis carried out in these according to differentiated methylated genes. DNA of selected significant candidates subsequently validated analyze association status genes with overall survival as well gene expression....
Metformin is a classic type II diabetes drug which possesses anti-tumor properties for various cancers. However, different cancers do not respond to metformin with the same effectiveness or acquire resistance. Thus, searching vulnerabilities of metformin-resistant prostate cancer promising strategy improve therapeutic efficiency drug. A genome-scale CRISPR-Cas9 activation library search targeting 23,430 genes was conducted identify that confer resistance in cells. Candidate were selected by...
Hoxa5 is preferentially expressed in haematopoietic stem cells (HSCs) and multipotent progenitor (MPPs), more highly expanding HSCs. To date, little known regarding the role of HSCs downstream vivo. In this study, we show that increased expression leads to aberrant erythropoiesis differentially modifies cell cycle lineage committed cells, depending on cellular context. drives HSCs, but not MPPs, through arrests erythroid G0 phase. Although HSC pool shrinks after overexpression Hoxa5, sustain...
Abstract Insect midgut cadherins function as receptors and play critical roles protein of insecticidal Bacillus thuringiensis (Bt) toxins used biopesticides in Bt transgenic crops worldwide. Here, we cloned characterized the full‐length cadherin (CmCad) cDNA from rice leaffolder ( Cnaphalocrocis medinalis ), a destructive pest many Asian countries. Expression recombinant proteins corresponding to extracellular domain CmCad allowed testing binding Cry proteins. Results vitro ligand blotting...
Purpose: To investigate the clinical relevance and biological function of kinesin super-family protein 4A (KIF4A) expression in prostate cancer (PCa). 
 Methods: We examined 1) relationship between KIF4A clinico-pathological characteristics PCa patients using a tissue microarray Cancer Genome Atlas database, 2) prognostic value Kaplan-Meier plots 3) functions LNCaP DU145 cells, such as cell proliferation, cycle apoptosis.
 Results: Compared with normal prostate, mRNA expressions...
Adrenocortical carcinoma (ACC) is a malignancy with poor prognosis and high mortality rate. A tumor mutational burden (TMB) has been found to be associated in ACC. Thus, exploring ACC biomarkers based on TMB holds significant importance for patient risk stratification. In our research, we utilized weighted gene coexpression network analysis an assay transposase-accessible chromatin high-throughput sequencing identify genes TMB. Through the comprehensive of various public datasets, Lamin B1...
Adrenocortical carcinoma (ACC) afflicts both pediatric and adult populations is characterized by dismal prognosis elevated mortality. Given the inconsistent therapeutic benefits significant side effects associated with conventional chemotherapy agent, mitotane, nascent stage of immunotherapy targeted treatments, there an urgent need to identify novel prognostic biomarkers targets in ACC.
以“早钟6 号”枇杷幼果为试材, 采用人工降温的方法, 观察接种冰核细菌后, 果肉细胞超微结构在冻害胁迫下的变化过程。结果显示: 冰核细菌不同程度地加重了冻害胁迫对枇杷果肉细胞壁、叶绿体和线粒体的破坏程度; 冰核细菌对叶绿体的破坏最明显, 其次是细胞壁、线粒体; 冰核细菌使叶绿体在-1 ℃发生胞内结冰导致细胞冻害, 而未感染冰核细菌的叶绿体则发生胞间结冰, 冻害类型不同; 与-1 ℃低温相比, -3 ℃低温条件下冰核细菌的破坏作用更强。表明冰核细菌的存在加重了低温对细胞的伤害。
Background: Metastatic castration-resistant prostate cancer (mCRPC) is a highly aggressive stage of cancer, and non-mutational epigenetic reprogramming plays critical role in its progression. Super enhancers (SE), elements, are involved multiple tumor-promoting signaling pathways. However, the SE-mediated mechanism mCRPC remains unclear. Methods: SE-associated genes transcription factors were identified from cell line (C4-2B) by CUT&Tag assay. Differentially expressed (DEGs) between primary...
Glioma is the most common primary brain tumor. Filamin-binding LIM protein 1 (FBLIM1) has been identified in multiple cancers and suspected of playing a part development tumors. However, potential function FBLIM1 mRNA glioma not investigated. In this study, clinical information transcriptome data patients were, respectively, retrieved from TCGA CGGA databases. The expression level was shown to be aberrant wide variety malignancies. Significantly, when samples were compared normal samples,...
冻害是影响和限制枇杷生产和发展的主要因素。本试验以“早钟6号”枇杷为试材, 采用人工降温的方法, 测定接种冰核细菌后, 枇杷叶片光合参数和叶绿素荧光动力学参数变化。结果显示: 冰核细菌的存在能显著降低低温胁迫下枇杷叶片的<i>Pn</i>、<i>Fm</i>、<i>Fv</i>、<i>Fv/Fo</i>、<i>Fv/Fm</i>和水分利用效率, 说明冰核细菌加重了低温对枇杷叶片光合机构的破坏性, 加重冻害发生。在接种冰核细菌条件下, -3 ℃比-1 ℃ <i>Pn</i>、<i>Fm</i>、<i>Fo</i>、<i>Fv</i>、<i>Fv/Fo</i>和<i>Fv/Fm</i>降低更显著且时间提前, 说明温度愈低, 冰核细菌对光合系统的破坏愈重且冻害发生时间提前。另外, <i>Tr</i>与冰核细菌的存在无显著相关性。
Objective To investigate the effect of hyperbaric oxygen (HBO) combined with temozolomide (TMZ) on apoptosis glioma U373MG cells and also to explore possible mechanism involved. Methods Upon completion cell culture, they were divided into 4 groups, i. e. control group, TMZ HBO group + group. The received neither nor drug treatment, only 50 μmol/L TMZ, just 0.24 MPa treatment for 3 hours was given after pretreatment. CCK-8 method used detect effects alone or use 2 methods proliferation...