A5021293109- Gastrointestinal Tumor Research and Treatment
- Sarcoma Diagnosis and Treatment
- MicroRNA in disease regulation
- Cancer-related molecular mechanisms research
- HIV Research and Treatment
- Virus-based gene therapy research
- Legume Nitrogen Fixing Symbiosis
- PI3K/AKT/mTOR signaling in cancer
- Circular RNAs in diseases
- Animal Virus Infections Studies
- Ultrasound and Hyperthermia Applications
- Neuroblastoma Research and Treatments
- Entomopathogenic Microorganisms in Pest Control
- RNA Interference and Gene Delivery
- Chronic Myeloid Leukemia Treatments
- Nematode management and characterization studies
- Cytokine Signaling Pathways and Interactions
- Viral Infectious Diseases and Gene Expression in Insects
- Immune Response and Inflammation
- Synthesis and biological activity
- Kruppel-like factors research
- Autophagy in Disease and Therapy
- Cancer Research and Treatments
- Protein Degradation and Inhibitors
- Marine Bivalve and Aquaculture Studies
Nanjing Normal University
2025
Hanzhong People's Hospital
2025
First Affiliated Hospital of Kunming Medical University
2016-2024
Harbin Medical University
2010-2024
Kunming Medical University
2016-2024
Heilongjiang Bayi Agricultural University
2021-2024
Third Affiliated Hospital of Harbin Medical University
2023
Northeast Agricultural University
2022
Ministry of Agriculture and Rural Affairs
2019-2022
Henan University
2022
Glioblastoma (GBM) is one of the most deadly brain tumors. The convenient access to Cancer Genome Atlas (TCGA) database allows for large-scale global gene expression profiling and mining potential correlation between genes overall survival a variety malignancies including GBM. Previous reports have shown that tumor microenvironment cells extent infiltrating immune stromal in tumors contribute significantly prognosis. Immune scores calculated based on ESTIMATE algorithm could facilitate...
Abstract Point mutations in the KIT receptor tyrosine kinase gene have recently been identified mucosal, acral lentiginous, and chronically sun-damaged melanomas. We first human melanoma cell line with an endogenous L576P mutation, most common mutation (∼30-40%). In vitro testing showed that viability of mutant was not reduced by imatinib, nilotinib, or sorafenib small molecule inhibitors effective nonmelanoma cells other mutations. However, dasatinib at concentrations as low 10 nM (P =...
Abstract Inversion symmetry broken 3R phase semiconducting transition metal dichalcogenides (TMDC) have huge potential applications in many novel fields, such as valleytronics and nonlinear optics for the strong spin–orbit coupling particularly persistent noncentrosymmetric structure regardless layer numbers, stark contrast to strict number requirement other phases. Unfortunately, fabrication of TMDC is still a task date. Molybdenum telluride (MoTe 2 ) attracts increasing interest recent...
Plant-parasitic nematodes secrete numerous effectors to facilitate parasitism, but detailed functions of nematode and their plant targets remain largely unknown. Here, we characterized four macrophage migration inhibitory factors (MIFs) in Meloidogyne incognita resembling the MIFs secreted by human animal parasites. Transcriptional data showed MiMIFs are up-regulated parasitism. Immunolocalization provided evidence that MiMIF proteins from hypodermis parasite surface, detected tissues giant...
Subversion of the host cell cycle to facilitate viral replication is a common feature coronavirus infections. Coronavirus nucleocapsid (N) protein can modulate cycle, but mechanistic details remain largely unknown. Here, we investigated effects manipulation porcine epidemic diarrhea virus (PEDV) N on and influence replication. Results indicated that PEDV induced Vero E6 arrest at S-phase, which promoted (P < 0.05). S-phase was dependent nuclear localization signal S71NWHFYYLGTGPHADLRYRT90...
Abstract Background Tar is the main toxic of cigarettes, and its effect on atherosclerosis progression underlying mechanisms remain largely unknown. Vascular smooth muscle cells (VSMCs) play a key role in atherogenesis plaque vulnerability. The present study sought to investigate mechanism through tar-induced VSMC necroptosis, recently described form necrosis. Methods tar necroptosis was examined ApoE −/− mice cultured VSMCs. development evaluated RIPK3-deletion (ApoE RIPK3 ). proteins...
Cell autophagy has been proposed to be involved in drug resistance therapy. However, how the long non-coding RNA (lncRNA) reduces risks of renal cancer (RC) cells needs a thorough inquiry. This study was assigned probe effect and mechanism HOTAIR on sunitinib RC.Clinical RC tissues para-carcinoma were obtained detect expressions miR-17-5p, Beclin1. Sunitinib-resistant (786-O-R ACHN-R) constructed using parental (786-O ACHN). The 786-O-R ACHN-R examined. Western blot qRT-PCR assayed obtain...
So far, there are still few studies on the prognostic factors of hepatocellular carcinoma (HCC) patients with macrovascular invasion (MVI) treated transcatheter arterial chemoembolization (TACE) combined intensity modulated radiotherapy (IMRT), and no relevant model has been established to predict prognosis such patients. Thus, purpose this study was determine HCC MVI after treatment TACE IMRT, establish a nomogram for forecasting 1-, 3-, 5-year overall survival (OS) who were diagnosed at...
Interferon (IFN)-γ induces the expression of gp91phox gene both during myeloid differentiation and also in mature phagocytes through several cis-elements their binding proteins. To find new for this induction, transient assays were performed using a reporter driven by serially truncated promoters U937 cells. The results suggest that critical cis-element induction exists region from bp −115 to −96 promoter. Site-directed mutagenesis showed γ-activated sequence (GAS) element at −100 (−100GAS)...
Heterodera avenae is one of the most important plant pathogens and causes vast losses in cereal crops. As a sedentary endoparasitic nematode, H. secretes effectors that modify defenses promote its biotrophic infection hosts. However, number involved interaction between host remains unclear. Here, we report identification putative regulate on large scale. Our results showed 78 95 suppressed programmed cell death (PCD) triggered by BAX 7 themselves caused Nicotiana benthamiana. Among...
We successfully synthesized {BiW8 }, a 10-nuclear heteroatom cluster modified O30 }. At 24 h post-incubation, the IC50 values of } against HUVEC, MG63, RD, Hep3B, HepG2, and MCF7 cells were 895.8, 127.3, 344.3, 455.0, 781.3, 206.3 μM, respectively. The value on MG63 was more than 2-fold lower that other raw materials. Through morphological functional features, we demonstrated pyroptosis as newly identified mechanism cell death induced by increased reactive oxygen species (ROS) levels in at...
PURPOSE: To assess whether a combination of functional (planar imaging and single photon emission computed tomography [SPECT]) anatomic (magnetic resonance [MR] imaging) techniques can be used to noninvasively quantify tumor expression somatostatin receptor type 2A (SSTR2A) gene chimera in vivo. MATERIALS AND METHODS: All animal experiments were approved by the institutional care use committee. Expression SSTR2A was quantified vitro, vivo, ex The epitope tag fusion protein detected through...
Abstract Purpose: Imatinib mesylate (imatinib) has revolutionized clinical outcomes of patients with advanced gastrointestinal stromal tumor (GIST). However, the degree individual benefit varies, and little is known about prognostic factors for these patients. Importantly, selected may be treated an approach to target both Kit vascular endothelial growth factor receptor (VEGFR) expression. Experimental Design: Using tissue microarray technology, we analyzed 53 imatinib-naive GISTs (VEGF)...
Long non‑coding RNAs have been reported to be involved in non‑small cell lung cancer (NSCLC) progression. However, whether Opa‑interacting protein 5 antisense RNA 1 (OIP5‑AS1) serves a role NSCLC remains unclear. Bioinformatics analysis of The Cancer Genome Atlas datasets showed clinical significance and relevance OIP5‑AS1 NSCLC. Western blotting reverse transcription‑quantitative PCR revealed protein RNA expression levels the genes [including <em>OIP5‑AS1</em>, microRNA...