A5016723703- Pregnancy and preeclampsia studies
- Birth, Development, and Health
- Neonatal Respiratory Health Research
- Hepatitis B Virus Studies
- Pulmonary Hypertension Research and Treatments
- Neonatal and fetal brain pathology
- Cancer-related molecular mechanisms research
- Advanced Neuroimaging Techniques and Applications
- Liver Disease Diagnosis and Treatment
- Hepatitis C virus research
- Gastric Cancer Management and Outcomes
- Immune Cell Function and Interaction
- Cerebrovascular and Carotid Artery Diseases
- Inflammasome and immune disorders
- Coronary Interventions and Diagnostics
- Autophagy in Disease and Therapy
- Circular RNAs in diseases
- Reconstructive Surgery and Microvascular Techniques
- T-cell and B-cell Immunology
- Cardiac Health and Mental Health
- MicroRNA in disease regulation
- Healthcare and Venom Research
- Ferroptosis and cancer prognosis
- Cancer Treatment and Pharmacology
- Trauma Management and Diagnosis
Harbin Medical University
2011-2025
Ministry of Education of the People's Republic of China
2022-2025
The Third People's Hospital of Dalian City
2025
Changsha University of Science and Technology
2025
Shaanxi Provincial People's Hospital
2016-2024
Shanxi Medical University
2016-2024
China Medical University
2019-2024
Second Affiliated Hospital of Harbin Medical University
2011-2024
Children's Hospital of Zhejiang University
2012-2023
Shanghai University of Traditional Chinese Medicine
2021-2022
Oxidative stress-associated proximal tubular cells (PTCs) damage is an important pathogenesis of hypertensive renal injury. We previously reported the protective effect VEGFR3 in salt-sensitive hypertension. However, specific mechanism underlying role kidney during overactivation renin-angiotensin-aldosterone system remains unclear. In present study, nephropathy was established by angiotensin II (Ang II). found that highly increased PTCs Ang II-infused mice. Activation mitigated dysfunction,...
Abstract Background Tar is the main toxic of cigarettes, and its effect on atherosclerosis progression underlying mechanisms remain largely unknown. Vascular smooth muscle cells (VSMCs) play a key role in atherogenesis plaque vulnerability. The present study sought to investigate mechanism through tar-induced VSMC necroptosis, recently described form necrosis. Methods tar necroptosis was examined ApoE −/− mice cultured VSMCs. development evaluated RIPK3-deletion (ApoE RIPK3 ). proteins...
Abstract Background Accumulating evidence reveals that intrauterine growth retardation (IUGR) can cause varying degrees of pulmonary arterial hypertension (PAH) later in life. Moreover, epigenetics plays an important role the fetal origin adult disease. The goal this study was to investigate development PAH following IUGR. Methods IUGR rats were established by maternal undernutrition during pregnancy. Pulmonary vascular endothelial cells (PVEC) isolated from rat lungs magnetic-activated cell...
Abstract Pyroptosis plays an important role in inflammatory diseases such as viral hepatitis and atherosclerosis. Apigenin exhibits various bioactivities, particularly anti‐inflammation, but its effect on pyroptosis remains unclear. The aim of this study is to investigate the apigenin explore potential against diseases. THP‐1 macrophages treated by lipopolysaccharides/adenosine 5′‐triphosphate were used vitro model. Western blot was detect expression NLRP3 inflammasome components key...
Gastric cancer (GC) poses a significant threat to public health. However, the clinicopathological features and tumor biological behaviors vary among GC patients, leading individual variations in lymph node metastasis. Consequently, stratification of dissection according specific type, particularly upper GC, has emerged as prominent area research. To investigate distribution metastatic nodes patients with lower analyze differences related pathological elements prognosis. Differential analysis...
The human brain demonstrates anatomical and functional lateralization/asymmetry between the left right hemispheres, such asymmetry is known to start from early age of life. However, how changes with development during infancy remained unknown. In this study, we aimed systematically investigate spatiotemporal pattern in healthy preterm-born infants first-half-year development, using high angular resolution diffusion MRI. Sixty-five (gestational 25.3–36.6 weeks) were scanned postmenstrual...
BACKGROUND:Regulatory B (Breg) cells are a group of with immunomodulatory function, which mainly exert negative function by secreting IL-10 and other cytokines. Due to their immunoregulatory properties, Breg may participate in the pathogenesis acute myeloid leukemia (AML). This study was designed explore frequency relationship between clinical data patients AML. MATERIAL AND METHODS:A total 46 (36 peripheral blood, 10 bone marrow) AML 15 healthy donors (HD) were included for detection...
Background The stress hyperglycemia ratio (SHR) has emerged as a potential prognostic indicator for various critical illnesses. However, its role in determining outcomes patients with atrial fibrillation (AF) within the intensive care unit (ICU) remains unclear. This study aimed to elucidate association between SHR and all-cause mortality this clinical setting. Methods We conducted retrospective cohort utilizing data from large, database. Critically ill documented AF were stratified based on...
Previous studies have shown that hepatitis B core antibody (anti-HBc) levels vary during different phases of disease in treatment-naïve chronic (CHB) patients and can be used as a predictor both interferon-α nucleoside analogue therapy response. However, there is no information on the association between quantitative serum anti-HBc (qAnti-HBc) level liver inflammation CHB patients. Therefore, we investigated these relationships large cohort A total 624 were included study. The qAnti-HBc was...
Background Intrauterine growth retardation ( IUGR ) is related to pulmonary artery hypertension in adults, and mi croRNA ‐206 (miR‐206) proposed affect the proliferation apoptosis of smooth muscle cells PASMC s) via post‐transcriptional regulation. Methods Results In an rat model, we found that expression function potassium voltage‐gated channel subfamily A member 5 (Kv1.5) s was inhibited, exaggerated after chronic hypoxia CH treatment as adults. micro RNA investigated from 12‐week‐old male...
Intrauterine life represents a window of phenotypic plasticity which carries consequences for later health in adulthood as well subsequent generations. growth-restricted fetuses (intrauterine growth restriction [IUGR]) have higher risk pulmonary arterial hypertension adulthood. Endothelial dysfunction, characterized by hyperproliferation, invasive migration, and disordered angiogenesis, is hallmark pathogenesis. Growing evidence suggests that intergenerational transmission disease, including...
Chronic hypoxia pulmonary hypertension (CH-PHT) in adulthood is likely to be of fetal origin following intrauterine growth retardation (IUGR). Oxygen (O₂)-sensitive voltage-gated potassium channels (Kv channels) resistance artery smooth muscle cells (PASMCs) play an important role scaling (PA) pressure. Expression and functional changes Kv are determined, part, by embryonic development. We hypothesized that O₂-sensitive exaggerated CH-PHT IUGR. established a rat model IUGR restricting...
Early postnatal life is considered as a critical time window for the determination of long-term metabolic states and organ functions. Extrauterine growth restriction (EUGR) causes development adult-onset chronic diseases, including pulmonary hypertension. However, effects nutritional disadvantages during early period on vascular consequences in later are not fully understood. Our study was designed to test whether epigenetics dysregulation mediates cellular memory this event.To hypothesis,...
Previous studies have revealed that hepatitis B core antibody (anti-HBc) levels vary throughout the different phases of treatment-naïve chronic (CHB) patients and can be used as a predictor treatment response in both interferon-α nucleoside analogue therapies. However, few data been published regarding relationship between quantitative anti-HBc (qAnti-HBc) liver fibrosis with CHB.A total 489 HBeAg-positive (HBeAg (+)) 135 HBeAg-negative (-)) were recruited. In HBeAg (+) (-) groups, S0-1/S0...