A5101426709- Mosquito-borne diseases and control
- Hedgehog Signaling Pathway Studies
- Epigenetics and DNA Methylation
- Viral Infections and Outbreaks Research
- Viral Infections and Vectors
- Chromatin Remodeling and Cancer
- RNA Research and Splicing
- Nutritional Studies and Diet
- Hepatitis Viruses Studies and Epidemiology
- RNA modifications and cancer
- Genomics and Chromatin Dynamics
- Genomic variations and chromosomal abnormalities
- Consumer Attitudes and Food Labeling
- DNA Repair Mechanisms
- Gastric Cancer Management and Outcomes
- Colorectal and Anal Carcinomas
- Drug Transport and Resistance Mechanisms
- Renal and Vascular Pathologies
- Organ Donation and Transplantation
- Cholangiocarcinoma and Gallbladder Cancer Studies
- RNA Interference and Gene Delivery
- Obesity, Physical Activity, Diet
- Diet and metabolism studies
- Cancer Mechanisms and Therapy
- Protein Degradation and Inhibitors
Shenyang Fifth People Hospital
2025
University of Southampton
2022-2024
Shanghai Jiao Tong University
2017-2021
The First Affiliated Hospital, Sun Yat-sen University
2019-2020
Sun Yat-sen University
2019-2020
MelroseWakefield Healthcare
2016
Jilin University
2015-2016
81th Hospital of PLA
2011
Gastric cancer (GC) poses a significant threat to public health. However, the clinicopathological features and tumor biological behaviors vary among GC patients, leading individual variations in lymph node metastasis. Consequently, stratification of dissection according specific type, particularly upper GC, has emerged as prominent area research. To investigate distribution metastatic nodes patients with lower analyze differences related pathological elements prognosis. Differential analysis...
Summary. The aim of this study was to further investigate the prevalence infection and genotype hepatitis E virus (HEV) among different species animals, people whose works are related pigs general population in suburb Beijing, China. Serum faecal samples were collected from 10 animal humans. Anti-HEV detected by enzyme immunoassays (EIA); HEV RNA amplified reverse transcription–nested polymerase chain reaction (RT-nPCR) method. PCR products cloned sequenced. isolated swine sequences analysed...
The aberrant hedgehog (Hh) pathway plays important roles in multiple cancer types, therefore serving as a promising drug target. Current clinically available hedgehog-targeted drugs act mostly by antagonizing the upstream component smoothened; however, both primary and acquired resistance to FDA-approved smoothened inhibitor (SMOi) have been described. We recently demonstrated that BET effectively suppresses SMOi-resistant Hh-driven cancers through transcription of GLI1 GLI2, core...
We previously identified an ATP-dependent human Ino80 (INO80) chromatin remodeling complex which shares a set of core subunits with yeast complex. Although research evidence has suggested that INO80 functions in gene transcription and genome stability, the precise mechanism remains unclear. Herein, based on expression profiles from complex-knockdown HeLa cells, we first demonstrate negatively regulates p21Waf1/Cip1 (p21) p53-mediated mechanism. In immunoprecipitation (ChIP) sequential ChIP...
Paediatric neuroblastoma and brain tumours account for a third of all childhood cancer-related mortality. High-risk is highly aggressive survival poor despite intensive multi-modal therapies with significant toxicity. Novel are desperately needed. The Zika virus (ZIKV) can access the nervous system there growing interest in employing ZIKV as potential therapy against paediatric tumours, including neuroblastoma.
The BCCIP (BRCA2- and CDKN1A-interacting protein) is an important cofactor for BRCA2 in tumor suppression. Although the low expression of observed multiple clinically diagnosed primary tissues such as ovarian cancer, renal cell carcinoma colorectal carcinoma, mechanism how regulated cells still unclear. human INO80/YY1 chromatin remodeling complex composed 15 subunits catalyzes ATP-dependent sliding nucleosomes along DNA. Here, we first report that a novel target gene by presenting series...
Abstract Hedgehog signaling is aberrantly activated in hematologic malignancies and solid tumors, targeting it a promising therapeutic strategy against these cancers. Resistance to clinically available hedgehog-targeted Smoothened inhibitor (SMOi) drugs has become critical issue hedgehog-driven cancer treatment. Our previous studies identified inhibition of BET CDK7 as two epigenetic/transcriptional-targeted strategies for overcoming SMOi resistance, providing direction anti-hedgehog drug...
To study the effect of Zhusha Anshen pill, cinnabar, HgS, HgCl2 and MeHg on gene expression renal transporters in mice.Healthy male mice were given equivalent physiological saline, pill (1.8 g · kg(-1), containing 0.17 kg(-1) mercury), cinnabar (0.2 1.7 high dose (2 HgS (0.032 0. 024 (0.026 0.024 once daily, for 30 d, measuring body mass gain. days later, sacrificed. The mercury accumulation kidneys was detected with atomic fluorescence spectrometer. Expressions Oat1, Oat2, Oat3, Mrp2, Mrp4,...
Abstract Background Metabolic disturbance is closely correlated with intrahepatic cholangiocarcinoma (IHCC), and we aimed to identify metabolic gene marker for the prognosis of IHCC. Methods We obtained expression clinical data from 141 patients IHCC public databases. Prognostic genes were selected using univariate Cox regression analysis. Unsupervised cluster analysis was applied subtypes, CIBERSORT used immune infiltration different subtypes. Then, signature screened multivariate LASSO...
<ns4:p>Background Paediatric neuroblastoma and brain tumours account for a third of all childhood cancer-related mortality. High-risk is highly aggressive survival poor despite intensive multi-modal therapies with significant toxicity. Novel are desperately needed. The Zika virus (ZIKV) can access the nervous system there growing interest in employing ZIKV as potential therapy against paediatric tumours, including neuroblastoma. Methods Here, we perform extensive data mining, integration...
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<p>Supplementary Table S1_Mouse_ sgRNA library_Sequences</p>
<p>Supplementary Table S3_Short Tandem Repeat (STR) analysis</p>
<ns3:p><ns3:bold>Background:</ns3:bold> Paediatric neuroblastoma and brain tumours account for a third of all childhood cancer-related mortality. High-risk is highly aggressive survival poor despite intensive multi-modal therapies with significant toxicity. Novel are desperately needed. The Zika virus (ZIKV) neurotropic there growing interest in employing ZIKV as potential therapy against paediatric nervous system tumours, including neuroblastoma.</ns3:p><ns3:p> <ns3:bold>Methods:</ns3:bold>...
Atypical Teratoid/Rhabdoid Tumor (AT/RT) is one of the most common aggressive brain tumors in infants with very poor prognosis. Although epigenetic dysregulation caused by loss functional SMARCB1 has been known to serve as its tumor hallmark, oncogenic driver well diagnostic biomarker, effective targeted therapeutic strategies against AT/RT are still needed. Our recent drug screening identified that BET inhibitor (BETi) and HDAC (HDACi) could dramatically inhibit cell viability multiple...
Abstract Background The evidence regarding the impact of healthy eating index on risk cardiovascular events among patients with type 2 diabetes (T2D) is limited. To examine associations adherence to Chinese and American dietary guidelines disease (CVD) individuals T2D. Methods This 1:1 matched case-control study included 419 enrolled pairs hospital-based CVD cases controls who were by age sex, in Guangdong province, China, all whom had A structured questionnaire a 79-item food-frequency was...
ABSTRACT BACKGROUND Paediatric neuroblastoma and brain tumours account for a third of all childhood cancer-related mortality. High-risk is highly aggressive survival poor despite intensive multi-modal therapies with significant toxicity. Novel are desperately needed. The Zika virus (ZIKV) neurotropic there growing interest in employing ZIKV as potential therapy against paediatric nervous system tumours, including neuroblastoma. METHODS Here, we perform an extensive meta-analysis infection...