A5100453092- Wound Healing and Treatments
- Peripheral Artery Disease Management
- Pregnancy and preeclampsia studies
- Gestational Diabetes Research and Management
- Electrospun Nanofibers in Biomedical Applications
- Diabetic Foot Ulcer Assessment and Management
- Vascular Procedures and Complications
- Metabolism, Diabetes, and Cancer
- Magnolia and Illicium research
- Mercury impact and mitigation studies
- Cerebrovascular and Carotid Artery Diseases
- Selenium in Biological Systems
- Diabetes, Cardiovascular Risks, and Lipoproteins
- Tissue Engineering and Regenerative Medicine
- Chronic Kidney Disease and Diabetes
- Extracellular vesicles in disease
- Chromatin Remodeling and Cancer
- Birth, Development, and Health
- Venous Thromboembolism Diagnosis and Management
- Protein Degradation and Inhibitors
- Pancreatitis Pathology and Treatment
- Peripheral Nerve Disorders
- Acute Myeloid Leukemia Research
- Folate and B Vitamins Research
- Bariatric Surgery and Outcomes
Shanghai Jiao Tong University
2016-2025
Shanghai First People's Hospital
2021-2025
Chengdu University of Traditional Chinese Medicine
2019-2025
North Sichuan Medical University
2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2015-2024
First Affiliated Hospital of Anhui Medical University
2024
Anhui Medical University
2024
XinHua Hospital
2018-2024
Institute of Hematology & Blood Diseases Hospital
2020-2024
Wuhan University
2019-2024
Abstract Background Mesenchymal stem cell (MSC)-derived exosomes emerge as promising candidates for treating delayed wound healing in diabetes due to the promotion of angiogenesis. Preconditioned MSC with chemical or biological factors could possibly enhance activities MSC-derived exosomes. The purpose this research focused on whether derived from bone marrow (BMSC) pretreated atorvastatin (ATV), exhibit better pro-angiogenic ability diabetic not and its underlying molecular mechanism....
Objective To determine if local prophylactic application of probiotic bacteria to burn wounds will prevent death in a mouse model wound sepsis. Background Infection remains the most common complication after injury and can result sepsis death, despite use topical systemic antibiotics. Pseudomonas aeruginosa is frequently implicated pathogen. Local probiotics directly an attractive novel intervention that avoids pitfalls standard antibiotic therapies. Methods A burn-sepsis was established...
Rationale: Chronic wounds associated with diabetes exact a heavy burden on individuals and society do not have specific treatment. Exosome therapy is an extension of stem cell therapy, RNA interference (RNAi)-based type advanced precision therapy. Based the discovery chronic wound-related genes in diabetes, we combined exosome RNAi through engineering approach for treatment diabetic wounds. Methods: We to establish diabetes-associated via engineered approach. Results: First, express low...
Objective To evaluate the diagnostic value of Inlet-to-outlet median nerve area ratio (IOR) in patients with clinically and electrophysiologically confirmed carpal tunnel syndrome (CTS). Methods Forty-six wrists 46 consecutive clinical electrodiagnostic evidence CTS forty-four 44 healthy volunteers were examined ultrasonography. The cross-sectional (CSA) was measured at inlet (the level scaphoid-pisiform) outlet hook hamate), IOR calculated for each wrist. Ultrasonography tests performed...
Lira-loaded PLGA/Gel could promote the diabetic wound repair by improvement of pro-angiogenic capacity <italic>via</italic> miR-29b-3p downregulation.
Perilla frutescens essential oil (PEO) has been widely used as a food preservative. This study aimed to clarify the mechanism of PEO against Aspergillus flavus (A. flavus) at protein level by using TMT proteomics. Marked changes in polysaccharides, proteins, and lipids A. were observed after treatment with PEO. Disordered energy metabolism damaged defense function occurred PEO-treated flavus. Proteomic analysis further manifested that inhibited growth blocking antioxidative process...
High-sensitivity C-reactive protein (hs-CRP) is an inflammatory marker. This study aimed to identify the correlation between hs-CRP levels and diabetic kidney disease (DKD) in patients with type 2 diabetes mellitus (T2DM).This cross-sectional observational included 927 T2DM. We collected data of based on their medical data, including sociodemographic characteristics, concomitant diseases, laboratory results, therapy. Multivariate logistic regression analysis was conducted assess relationship...
Insulin resistance and beta cell dysfunction were reported to be responsible for gestational diabetes mellitus (GDM). However, little is known about the heterogeneity of these factors its influences on perinatal outcomes. We investigated whether subtypes insulin in have different impacts In this prospective cohort study, we followed 554 pregnant women glucose challenge test was performed at 24–28th weeks their gestation. Women with plasma ≥ 7.8 mmol/L would included advised undergo...
Abstract Cold atmospheric plasma (CAP) is a group of various chemical active species, such as ozone and nitric oxide, generated by working gas. CAP was demonstrated to have an effect on tissue regeneration wound healing. We conducted this study evaluate the efficacy safety novel therapy for diabetic wounds in vitro vivo. The consists ionised helium gas that produced high‐voltage high‐frequency power supply. Eight‐week‐old male db/db mice C57BL were treated with (control group), 90s'...
The coral symbiont Symbiodinium plays important roles in the adaptation of to environmental changes. However, coral-Symbiodinium symbiotic associations are not well-understood South China Sea (SCS) whilst considering factors and host taxa. In this study, next-generation sequencing internal transcribed spacer region 2 (ITS2) marker gene was used explore between five typical species across tropical subtropical reef regions SCS. results showed that Acropora sp., Galaxea fascicularis, Platygyra...
To assess the feasibility and efficacy of subintimal angioplasty (SA) in treatment below-the-ankle arterial occlusion diabetic patients with chronic critical limb ischemia (CLI).SA was applied 37 (24 men; mean age 70.9+/-8.5 years, range 52-88) CLI occlusive disease dorsalis pedis artery (DPA) and/or plantar (PA) but were poor candidates for intraluminal or bypass surgery. Tissue loss present 31 (54.4%) 57 afflicted limbs, rest pain reported 51 (89.5%) limbs. SA performed to create...
Fibroblast growth factor 21 (FGF21) is an emerging metabolic regulator associated with glucose and lipid metabolism, it still unclear whether FGF21 related to atherosclerosis. Here, we explored the potential link between lower extremity atherosclerotic disease (LEAD) in type 2 diabetic patients. A cross-sectional study was conducted on 504 patients (283 men, 221 women). LEAD defined by Ankle-brachial index (ABI) <0.9 arterial plaque evaluated color Doppler ultrasound. Serum concentrations...
Nicotinamide adenine dinucleotide (NAD+) is a critical molecule involved in various biological functions. Poly (ADP-ribose) polymerase 1 (PARP1) and sirtuin (SIRT1) affect cellular NAD+ levels play essential roles regulating metabolism. However, there has been little research on the effects of PARP1 SIRT1 crosstalk during senescence. We isolated endothelial progenitor cells (EPCs) from human umbilical cord blood treated them with inhibitor (PJ34). Using stress-induced premature aging model...
Direct in vivo investigation of human placenta trophoblast's susceptibility to SARS-CoV-2 is challenging. Here we report that trophoblast stem cells (hTSCs) and their derivatives are susceptible infection, which reveals heterogeneity hTSC cultures. Early syncytiotrophoblasts (eSTBs) generated from hTSCs have enriched transcriptomic features peri-implantation trophoblasts, express high levels angiotensin-converting enzyme 2 (ACE2), productively infected by its Delta Omicron variants produce...
Abstract Surface termination is so far the mainstream passivating method to enhance performance of CsPbI 3 solar cells. However, surface can hardly achieve effective and homogeneous passivation on large‐area films, which one key challenge toward high‐performance inorganic perovskite modules (PSMs). The strong ionic bond between Cs Pb‐I framework in makes it difficult construct 2D layer film via post treatment, otherwise a classic effectual approach for defect elimination organic–inorganic...
Background: The efficacy and safety of endovascular thrombectomy (EVT) in patients with large ischemic infarcts have been the focus recent research, yet discrepancies persist between studies. This meta-analysis evaluates EVT using data from randomized controlled trials (RCTs) real-world cohort Methods: A systematic search PubMed, Web Science, Embase January 1, 2010, to June 17, 2024, identified studies reporting favorable functional outcome (FFO), moderate (MFO), symptomatic intracranial...
ABSTRACT Aims The diagnosis of diabetic peripheral neuropathy (DPN) remains challenging because the lack objective biomarkers. In this study, we explored niacin‐induced skin flushing response (NSFR) as a novel diagnostic biomarker for DPN on basis its association with microangiopathy. Materials and Methods We recruited 114 patients type 2 diabetes (51 DPN, 59 without 4 unclear status) 91 healthy controls. Peripheral was assessed through clinical symptoms signs, vibration threshold testing...