A5101740624- Diabetes Treatment and Management
- Diabetic Foot Ulcer Assessment and Management
- Surgical site infection prevention
- Metabolism, Diabetes, and Cancer
- Diet and metabolism studies
- Lung Cancer Treatments and Mutations
- Bariatric Surgery and Outcomes
- Anorectal Disease Treatments and Outcomes
- Cardiovascular Health and Disease Prevention
- Head and Neck Surgical Oncology
- Vitamin D Research Studies
- Surgical Sutures and Adhesives
- Streptococcal Infections and Treatments
- Neurological and metabolic disorders
- Wound Healing and Treatments
- Cancer Mechanisms and Therapy
- Retinal Diseases and Treatments
- Reconstructive Surgery and Microvascular Techniques
- PI3K/AKT/mTOR signaling in cancer
- Blood donation and transfusion practices
- Ureteral procedures and complications
- Surgical Simulation and Training
- Anatomy and Medical Technology
- Balance, Gait, and Falls Prevention
- Blood transfusion and management
Ningxia Medical University
2018-2024
Harbin Medical University
2024
First Affiliated Hospital of Harbin Medical University
2024
Shanghai Jiao Tong University
2015-2023
Shanghai Sixth People's Hospital
2013-2023
Ruijin Hospital
2023
Army Medical University
2013-2022
Peking University
2012-2022
Chinese Academy of Medical Sciences & Peking Union Medical College
2022
Peking University First Hospital
2012-2020
Abstract Although extracellular DNA is known to form immune complexes (ICs) with autoantibodies in systemic lupus erythematosus (SLE), the mechanisms leading release of from cells remain poorly characterized. Here, we show that pore-forming protein, gasdermin D (GSDMD), required for nuclear and mitochondrial (mtDNA) neutrophils lytic cell death following ex vivo stimulation serum patients SLE IFN-γ. Mechanistically, activation FcγR downregulated Serpinb1 SLE, spontaneous both...
Abstract Aims To investigate the relationship between vitamin D deficiency and diabetic retinopathy. Methods In total, 1520 patients with Type 2 diabetes were recruited divided into three groups according to their fundus oculi results: no retinopathy ( n = 625, 41.12%); non‐sight‐threatening 562, 36.97%); sight‐threatening 333, 21.91%). Vitamin was defined as a serum circulating 25–hydroxyvitamin level < 20 ng/ml. Clinical characteristics biochemical parameters detected compared. Results...
Abstract Background Vitamin D deficiency was reported to be associated with diabetic peripheral neuropathy. But the association in Chinese population and screening value of vitamin for neuropathy were unknown. Methods A total 861 patients type 2 diabetes recruited this cross‐sectional study. defined as serum circulating 25‐hydroxyvitamin D(25(OH)D) level < 20 ng/mL. Peripheral evaluated by neurological symptoms, signs, neurothesiometer electromyogram. Results The had significantly lower...
Abstract Cold atmospheric plasma (CAP) is a group of various chemical active species, such as ozone and nitric oxide, generated by working gas. CAP was demonstrated to have an effect on tissue regeneration wound healing. We conducted this study evaluate the efficacy safety novel therapy for diabetic wounds in vitro vivo. The consists ionised helium gas that produced high‐voltage high‐frequency power supply. Eight‐week‐old male db/db mice C57BL were treated with (control group), 90s'...
Abstract Background Negative pressure wound therapy (NPWT) is one of the most important treatments for diabetic foot, but underlying mechanisms its benefits still remain elusive. This study aims to evaluate inflammatory signals involved in effects negative on foot ulcers. Methods We enrolled 22 patients with ulceration, 11 treated NPWT and other traditional debridement. All were observed 1 week. Granulation tissues harvested analyzed both groups, then histologically immunohistochemically...
BackgroundDespite of its significant therapeutic effects on obesity and metabolic diseases, Roux-en-Y gastric bypass (RYGB) has limited clinical application because considerable impacts the gastrointestinal structure postoperative complications. This study aims to develop a simplified surgical approach with less damage complication but efficient benefit.MethodsThe Esophagus-Duodenum (EDGB) body weight, food intake, glucose lipid metabolism were compared RYGB in mice.FindingsEDGB is simple,...
Abstract The aim of this study was to investigate the effect testosterone and oestrogen on regulating organic cation transporters (Octs) multidrug toxin extrusions (Mates) expression in kidney mice urinary excretion metformin. 8 week‐old male db/db were treated with estradiol (5 mg/kg), (50 mg/kg) or olive oil same volume. Metformin (150 injected daily for successive 7 days. Plasma, urine tissue concentrations metformin determined by liquid chromatography‐tandem mass spectrometry (LCMS)...
Atrial fibrillation (AF) is a prevalent cardiac arrhythmia associated with increased morbidity and mortality, highlighting the need for novel therapeutic strategies. This study aimed to evaluate effects of B-type natriuretic peptide (BNP) on structural remodeling in rabbit model AF. Rabbits were subjected rapid pacing induce an AF model, BNP was delivered subcutaneously at dose 20 μg/kg/d twice per day three weeks. Electrophysiological measurements taken assess induction rate atrial...
Background: Short-term use of standard-dose proton pump inhibitors (PPIs) is the first-line initial non-eradication treatment for duodenal ulcer (DU), but choice on individual PPI drug still controversial. The purpose this study to compare efficacy, safety, and cost-effectiveness medications in DU. Methods: We searched PubMed, Embase, Cochrane Library, Clinicaltrials.gov, China National Knowledge Infrastructure, VIP database, Wanfang database from their earliest records September 2017....
Abstract Objective To investigate the relationship between ankle‐branchial index (ABI) and cardiovascular disease in type 2 diabetes patients. Methods A total of 634 inpatients with were recruited this cross‐sectional study. All patients measured ABI computed tomography angiography (CTA) scan for coronary artery (CAD). According to values, divided into three groups: low‐ABI group (ABI < 0.9, n = 259), normal‐ABI 0.9‐1.3, 272), high‐ABI > 1.3, 103). manifestation CTA, CAD (n 348)...
Rationale: Retroperitoneal necrotizing soft tissue infection (NSTI) is a rare but life-threatening disease. Here, we present case of extended retroperitoneal NSTI caused by extended-spectrum beta-lactamase (ESBL)-producing Escherichia coli (E coli). Patient concerns: The patient complained progressive redness, swelling, and right flank pain for 10 days, extending to the scrotum 1 day. Diagnoses: He was admitted with an initial diagnosis cellulitis. Interventions: Debridement performed after...
To advance blood transfusion safety, the Chinese Haemovigilance Network (CHN) was put into operation in 2018. This report describes development of CHN and evaluates its role by analysing reported adverse reactions (ATRs) from 2018 to 2020.All data this study were obtained online reporting platform. A timeline is presented, activities CHN-enrolled facilities are analysed year. The ATRs detail for ATR types, components involved adherence case definition, severity imputability criteria....
To validate the therapeutic efficacy of metformin on diabetic bladder dysfunction (DBD) and further elucidate whether TXNIP-NLRP3-GSDMD axis serves as a target for in ameliorating DBD. C57BL/6J mice were induced with diet-induced obesity by being fed high-fat diet (HFD) 16 weeks. After establishing model, treated 4 weeks, their glucose metabolism-related parameters assessed. Urine spot assays urodynamic measurements conducted to reflect function urinary behavior mice, while histological...
Abstract Background: Chemotherapy-induced nausea and vomiting (CINV) make many patients have negative adherence of treatment. Acupuncture has been widely applied in treatment CINV, but its efficacy not evaluated scientifically systematically recent years. Hence, evaluating the safety effectiveness acupuncture with CINV is main purpose this review. Methods analysis: We will search following electronic databases from inception to Mar 2020: Cochrane Central Register Controlled Trials, EMBASE,...
Diabetes mellitus (DM) is a clinical condition that affects gait performance and control in millions of individuals worldwide. Contrary to basic spatiotemporal parameters, gait-based spectral analysis may provide useful insights into neuromotor control. Hence, this study was set investigate the content at preferred speed patients with DM. Total 1117 [658 DM 649 healthy adults (HA)] performed 10 m walk while wearing an inertial measurement unit over fourth lumbar vertebra. Mann-Whitney-U test...
Objective Roux-en-Y gastric bypass is an effective intervention for metabolic disorder. We aim to elucidate whether ghrelin contributes weight reduction, and glycemic lipid control after (RYGB). Design Four-week-old WT Ghrl-TSC1 -/- mice were fed high fat diet 12 weeks before surgery, continued be on the same 3 surgery. Body weight, food intake, metabolism analyzed Results Gastric circulating was significantly increased in with RYGB Hypoghrelinemia elicited by deletion of TSC1 activate mTOR...