A5084741386- Osteoarthritis Treatment and Mechanisms
- Bone Tissue Engineering Materials
- Magnesium Alloys: Properties and Applications
- Orthopaedic implants and arthroplasty
- Cancer-related molecular mechanisms research
- MicroRNA in disease regulation
- Diabetic Foot Ulcer Assessment and Management
- Inflammatory mediators and NSAID effects
- Hepatocellular Carcinoma Treatment and Prognosis
- Ferroptosis and cancer prognosis
- Lymphoma Diagnosis and Treatment
- Rheumatoid Arthritis Research and Therapies
- Aquatic Ecosystems and Phytoplankton Dynamics
- Bone Metabolism and Diseases
- Nanoplatforms for cancer theranostics
- Circular RNAs in diseases
- Extracellular vesicles in disease
- RNA modifications and cancer
- Acute Myocardial Infarction Research
- Total Knee Arthroplasty Outcomes
- Orthopedic Infections and Treatments
- Aluminum Alloys Composites Properties
- Lung Cancer Treatments and Mutations
- Acute Myeloid Leukemia Research
- Autoimmune and Inflammatory Disorders Research
Peking University Shenzhen Hospital
2016-2025
Sun Yat-sen University
2025
Fifth Affiliated Hospital of Sun Yat-sen University
2025
Zhejiang Cancer Hospital
2013-2024
Army Medical University
2010-2024
Chinese Academy of Sciences
2018-2024
First Hospital of Jiaxing
2017-2024
Jiaxing University
2017-2024
Ganzhou People's Hospital
2024
Shenzhen Second People's Hospital
2024
Natural polysaccharide (NPH)-based injectable hydrogels have shown great potential for critical-sized bone defect repair. However, their osteogenic, angiogenic, and mechanical properties are insufficient. Here, MgO nanoparticles (NPs) were incorporated into a newly synthesized water-soluble phosphocreatine-functionalized chitosan (CSMP) water solution to form an hydrogel (CSMP-MgO) via supramolecular combination between phosphate groups in CSMP magnesium NPs circumvent these drawbacks of...
Abstract Intra-articular injection of therapeutics is an effective strategy for treating osteoarthritis (OA), but it hindered by rapid drug diffusion, thereby necessitating high-frequency injections. Hence, the development a biofunctional hydrogel improved delivery required. In this study, we introduce liposome-anchored teriparatide (PTH (1–34)) incorporated into gallic acid-grafted gelatin injectable (GLP hydrogel). We show that GLP can form in situ and without affecting knee motion after...
Microcystins have been reported to be carcinogenic by animal and cell experimentation, but there are no data on the linkage between serum microcystins hepatocellular carcinoma (HCC) risk in humans. We conducted a clinical case-control study investigate association HCC after controlling several known factors, such as hepatitis B virus, alcohol, aflatoxin. From December 2013 May 2016, 214 patients newly diagnosed with along controls (frequency-matched age sex) were recruited from three...
Pancreatic cancer (PC) is a highly malignant tumor with increased morbidity and mortality, which difficult to diagnose cure in the clinic. Through secreting exosomes containing biological molecules, including diverse RNAs proteins, bone marrow mesenchymal stem cells (BM-MSCs) influence immunity, inflammation, environment, metastasis. In this study, low expression of miRNA-1231 (miR-1231) derived from peripheral blood was significantly correlated TNM stage PC, suggesting potential inhibitory...
Inspired by the process of bone reconstruction, porous scaffolds with robust osteogenesis and biodegradability would provide an ideal substitute for clinical practice. In this study, a novel Mg–Nd–Zn–Zr (JDBM) alloy scaffold coated brushite (i.e., DCPD), denoted as JDBM-DCPD, is fabricated using special patent template technique, which forms main spherical pores (400–450 μm) smaller (150–250 interconnected between adjacent pores, facilitating nutrient penetration cell in-growth, exhibiting...
Osteoarthritis is the most common disabling joint disease throughout world, and effect of therapy on its course still unsatisfactory in clinical practice. Recent studies have shown that mesenchymal stem cell (MSC)-derived exosomes can promote cartilage repair regeneration osteoarthritis, indicating these could be a novel promising strategy for treating osteoarthritis. This study investigated whether low-intensity pulsed ultrasound (LIPUS) enhances effects bone marrow MSC (BMSC)-derived...
During the past decade, mounting evidence has increasingly linked programmed cell death (PCD) to progression and development of osteoarthritis (OA).There is a significant need for thorough scientometric analysis that recapitulates relationship between PCD OA.This study aimed collect articles reviews focusing on in OA, extracting data from January 1st, 2013, October 31st, 2023, using Web Science.Various tools, including VOSviewer, CiteSpace, Pajek, Scimago Graphica, R package, were employed...
Although the nephrotoxicity of microcystin and aflatoxin has been observed in animal clinical cases, few population data are available. We conducted a cross-sectional study Southwest China to investigate association renal function indicators (RFIs, including BUN, SCr, eGFR) with exposure 5493 members general population. Microcystin-LR levels water aquatic products B1 daily foods were measured by ELISA, individual estimated intake (EDI) was assessed on basis measurement questionnaire. found...
Interconnectivity is the key characteristic of bone tissue engineering scaffold modulating cell migration, blood vessels invasion and transport nutrient waste. However, efforts understanding interconnectivity porous Mg limited due to diverse architectures pore struts size distribution systems. In this work, biomimetic hierarchical scaffolds with tailored as well were prepared by template replication infiltration casting. better showed lower mechanical strength. Enlarging interconnected pores...
It has been widely accepted that monocytes are one of the central mediators contributing to inflammaging. However, it remains unclear whether aged monocytes, similar T cells, have characteristics hyperactivation and increased expression co-inhibitory molecules.Peripheral blood mononuclear cells (PBMCs) were isolated from young (21-40 years old), middle-aged (41-60 older human subjects (> 60 old). Flow cytometry was used monitor changes in surface molecules monocyte subsets cytokine-producing...
Abstract Osteoarthritis (OA) is a degenerative disease caused by variety of factors with joint pain as the main symptom, including fibrosis, chapping, ulcers, and loss cartilage. Traditional treatment can only delay progression OA, classical delivery system have many side effects. In recent years, microspheres shown great application prospects in field OA treatment. Microspheres support cells, reproduce natural tissue microenvironment vitro vivo, are an efficient for release drugs or...