A5100368577- Osteoarthritis Treatment and Mechanisms
- Inflammatory mediators and NSAID effects
- COVID-19 and healthcare impacts
- Total Knee Arthroplasty Outcomes
- Nanoparticle-Based Drug Delivery
- Nanoplatforms for cancer theranostics
- RNA Interference and Gene Delivery
- Orthopaedic implants and arthroplasty
- Bone Tissue Engineering Materials
- Enhanced Recovery After Surgery
- Graphene and Nanomaterials Applications
- Climate Change and Health Impacts
- Bone health and treatments
- Chemokine receptors and signaling
- Bone Metabolism and Diseases
- Orthopedic Infections and Treatments
- Cardiac, Anesthesia and Surgical Outcomes
- COVID-19 Clinical Research Studies
- Clinical practice guidelines implementation
- Autophagy in Disease and Therapy
- Genetic Associations and Epidemiology
- Hip and Femur Fractures
- Extracellular vesicles in disease
- Infection Control and Ventilation
- Bone and Dental Protein Studies
Peking University Shenzhen Hospital
2019-2024
Capital Medical University
2024
Beijing Jishuitan Hospital
2024
Peking University
2024
First Affiliated Hospital of Xinjiang Medical University
2021
Xinjiang Medical University
2021
Northeast Normal University
1995
Institute of Theoretical Physics
1995
Abstract Intra-articular injection of therapeutics is an effective strategy for treating osteoarthritis (OA), but it hindered by rapid drug diffusion, thereby necessitating high-frequency injections. Hence, the development a biofunctional hydrogel improved delivery required. In this study, we introduce liposome-anchored teriparatide (PTH (1–34)) incorporated into gallic acid-grafted gelatin injectable (GLP hydrogel). We show that GLP can form in situ and without affecting knee motion after...
Abstract Background A former cohort study has raised concern regarding the unanticipated hazard of omeprazole in expediting osteoarthritis (OA) advancement. The precise nature their causal evidence, however, remains undetermined. present research endeavors to investigate underlying link between and OA through application mendelian randomization (MR) analysis. Methods incorporated ukb-a-106 ukb-b-14,486 datasets. investigation effects employed methodologies such as MR-Egger, Weighted median,...
Osteoarthritis (OA) is a degenerative joint disease with multiple etiologies that affects individuals worldwide. No effective interventions are currently available to reverse the pathological process of OA. Sodium butyrate (NaB), component short-chain fatty acids (SCFAs), has biological activities, including attenuation inflammation and anti-tumor activities in various diseases. However, whether protective effects NaB OA associated promotion autophagy had not been investigated. Here, we...
Abstract Objectives The purpose of this study is to identify the factors that influence length stay (LOS) in total knee arthroplasty (TKA) patients with an enhanced recovery after surgery (ERAS) program. Methods Information from 167 (31 males and 136 females, range 43 years 88 old) who underwent unilateral elective primary TKA January 2017 2019 were reviewed retrospectively. Factors analyzed by single-factor variance multi-factor linear regression. Results By analysis, American Society...
Knee osteoarthritis (KOA) is a highly prevalent musculoskeletal disorder characterized by degeneration of cartilage and abnormal remodeling subchondral bone (SCB). Teriparatide (PTH (1-34)) an effective anabolic drug for osteoporosis (OP) regulates osteoprotegerin (OPG)/receptor activator nuclear factor ligand (RANKL)/RANK signaling, which also has therapeutic effect on KOA ameliorating degradation inhibiting aberrant SCB. However, the mechanisms PTH (1-34) in treating are still uncertain...
Over the past few years, tissue-engineering technology provided a new direction for bone defects therapy, which involved developing applicable biological materials composite with seed cells to repair tissue.
Introduction: Chemotherapy is a common strategy for the treatment of osteosarcoma. However, its therapeutic efficacy not ideal due to low targeting, lowbioavailability, and high toxicity chemotherapy drugs. Nanoparticles can improve residence time drugs at tumor sites through targeted delivery. This new technology reduce risk patients survival rates. To achieve this goal, we developed pHsensitive charge-conversion polymeric micelle [mPEG-b-P(C7-co-CA) micelles] osteosarcoma-targeted delivery...
Abstract Background Coronavirus disease 2019 (COVID-19) has broken out and spread rapidly nationwide at the beginning of 2020, which brought huge impacts to people work. The current situation prevention control is severe urges guidance for clinicians, especially medical systems. In hope providing a reference recommendation COVID-19, we carried research improve quality patient care during this epidemic. Methods All staff were trained master personal protection in our department. We reviewed...
This study aims to investigate the possible association and comparison between anterolateral approach (ALA) posterolateral (PLA) postoperative lower limb discrepancy (LLD) in selective total hip arthroplasty (THA).April 2021 July 2021, a of 266 consecutive patients (126 males, 140 females; mean age: 46.7±13.6 years; range, 22 60 years) who underwent unilateral primary THA via ALA or PLA were retrospectively analyzed. The operations performed by single surgical team. All divided into two...
Total hip arthroplasty (THA) is a successful treatment for many diseases. Length of stay (LOS) and hospital cost are crucial parameters to quantify the medical efficacy quality unilateral primary THA patients. Clinical variables associated with LOS costs haven't been investigated thoroughly.The present study retrospectively explored contributors among total 452 patients from January 2019 2020. All received conventional in-house rehabilitation services within our institute prior discharge....
Enhanced recovery after surgery (ERAS) has been successfully adopted for the improvement of medical quality and efficacy in many diseases, but effect thereof ankle fracture patients can vary. The aim present study was to explore short-term postoperative outcomes ERAS among patients.The a retrospective cohort conducted between January 2019 May 2019. One hundred sixty participations (58 males 102 females, aged 41.71 ± 14.51 years) were included. participants treated with open reduction...
In clinical settings, regenerating critical-sized calvarial bone defects presents substantial problems owing to the intricacy of surgical methods, restricted growth medications, and a scarcity commercial grafts. To treat this life-threatening issue, improved biofunctional grafts capable properly healing are required. study, we effectively created anti-fracture hydrogel systems using spongy-like metal-organic (magnesium-phosphate) coordinated chitosan-modified injectable hydrogels (CPMg)...
In this study, we explore the cartilage defect repair mechanism by phosphocreatine-grafted chitosan hydrogels loaded with berberine-treated ATDC5 cells (CSMP@BBR@ATDC5). Under optimal concentrations of LPS and BBR ideal conditions, cell toxicity proliferation were detected AM/PI EdU staining. Additionally, qPCR Western blot employed to detect expression SIRT1/BMP4 signaling pathway chondrogenic-related factors in cells. Moreover, BBR-treated was seeded into a hydrogel system. Subsequently,...
Abstract Background Coronavirus disease 2019 (COVID-19) broken out and spread rapidly nationwide at the beginning of 2020, which has brought huge impacts to people work. The current situation prevention control is severe urgent guidance for clinicians, especially medical systems. In hope providing a reference recommendation epidemic, we carried research improve quality patients care during this epidemic. Methods All involved health personnel were trained use personal protection equipment in...
Abstract Background . Chondrocyte apoptosis plays a significant role in the pathogenesis of osteoarthritis (OA), but mechanism remains unclear. This research aimed to elucidate effect mitochondrial oxidative stress on chondrocyte through ROS/NF-κB pathway. Methods Mouse chondrocytes exposed lipopolysaccharide (LPS) were used as OA models vitro. Cell viability was tested by CCK-8. proliferation, apoptosis, reactive oxygen species (ROS), and membrane potential detected fluorescence microscopy...