A5058286534- Chronic Lymphocytic Leukemia Research
- Opioid Use Disorder Treatment
- Regulation of Appetite and Obesity
- Forensic Toxicology and Drug Analysis
- Municipal Solid Waste Management
- COVID-19 and healthcare impacts
- Landfill Environmental Impact Studies
- Biosimilars and Bioanalytical Methods
- Pancreatic and Hepatic Oncology Research
- Hepatocellular Carcinoma Treatment and Prognosis
- Neuroscience and Neuropharmacology Research
- Heavy Metal Exposure and Toxicity
- Breast Cancer Treatment Studies
- Pancreatic function and diabetes
- Neuropeptides and Animal Physiology
- Drug Transport and Resistance Mechanisms
- Asthma and respiratory diseases
- Neurotransmitter Receptor Influence on Behavior
- Global Cancer Incidence and Screening
- Receptor Mechanisms and Signaling
- COVID-19 Clinical Research Studies
- Plant-based Medicinal Research
- Lymphoma Diagnosis and Treatment
- Glycosylation and Glycoproteins Research
- Intracerebral and Subarachnoid Hemorrhage Research
Mayo Clinic in Arizona
2024-2025
Mayo Clinic
2024-2025
WinnMed
2024-2025
Chinese Academy of Medical Sciences & Peking Union Medical College
2018-2023
ARUP Institute for Clinical and Experimental Pathology
2022-2023
ARUP Laboratories (United States)
2020-2023
Affiliated Hospital of Jiangsu University
2023
Jiangsu University
2023
University of Utah
2020-2022
Hebei University of Engineering
2018-2022
Kinase inhibitors are small-molecule drugs designed to target oncogenic mutations in cancer treatment. Although less toxic than conventional chemotherapy drugs, they can cause severe adverse effects some patients, resulting dose reduction and cessation. To evaluate if therapeutic drug monitoring of kinase their metabolites improve toxicity assessment we developed evaluated the analytical performance two parallel methods utilizing liquid chromatography (LC) paper spray (PS) ionization coupled...
Background: Shuanghuanglian injection (SHLI) is a famous Chinese medicine used as an intravenous preparation for the treatment of acute respiratory tract infections. In recent years, immediate hypersensitivity reactions induced by SHLI have attracted broad attention. However, mechanism involved in these has not yet been elucidated. The present study aims to explore characteristics and deciphers role RhoA/ROCK signaling pathway reactions. Methods: SHLI-immunized mice or naive were...
Feeding is regulated by perception in the hypothalamus, particularly first-order arcuate nucleus (ARC) neurons, of body's energy state. However, cellular device for converting states to activity critical neurons ARC less defined. We here show that Na + ,K -ATPase (NKA) senses regulate feeding. Fasting-induced systemic ghrelin rise and glucose lowering reduced ATP-hydrolyzing NKA its substrate ATP level, respectively, preferentially ARC. Lowering concentration (LG), which mimics fasting,...
Urine drug testing (UDT) is a critical tool used in medical, forensic, and occupational settings, but interpreting results can be challenging. We performed study to assess the ability of health care professionals interpret UDT accurately.
Nesfatin-1 is a hypothalamic anorexigenic peptide processed from nucleobindin 2 (NUCB2). Central and peripheral administration of NUCB2/nesfatin-1 enhances glucose metabolism insulin release. also localized in pancreatic islets, while its function remains unknown. To explore the role β-cell-produced NUCB2/nesfatin-1, we developed β-cell-specific NUCB2 knockout (βNUCB2 KO) mice gene knockdown (shNUCB2) MIN6 β-cell line. In βNUCB2 KO mice, casual blood was elevated 12 weeks age. tolerance test...
Prediction of postoperative survival for hilar cholangiocarcinoma (HCCA) remains difficult although there have been a variety clinical classification and staging systems. This study was designed to validate compare some the major HCCA systems in use today. In addition, we sought build up new system modified from Jarnagin-Blumgart (J-B) HCCA, predict better.A total 154 consecutive cases including 95 surgical patients between 2005 2014 were enrolled this study. The pathological data recorded...
Elevated serum alpha-fetoprotein (AFP) can be observed in liver cirrhosis and hepatocellular carcinoma (HCC). The glycosylation patterns of AFP have been shown to differentiate these conditions, with glycoforms core fucosylation (AFP-L3) serving as a malignancy risk predictor for HCC. We developed method detect endogenously present proteoforms quantify the relative abundance AFP-L3 (AFP-L3%) samples. This consists immune enrichment endogenous AFP, followed by liquid chromatography coupled...
Nanofiltration (NF) technology is a membrane-based separation process, which has been pervasively used as the high-effective for drinking water treatment. In this study, kind of composite polyamide NF thin film selected to investigate removal efficiencies and mechanisms 14 trace drugs, are commonly frequently detected in water. The results show that most drugs quite high, indicating an effective improve quality carbamazepine, acetaminophen, estradiol, antipyrine isopropyl-antipyrine...
As Asian American breast cancer incidence rises, it is necessary to investigate the origins of differential outcomes among ethnic subgroups. This study aimed examine disparities in delays surgery subgroups.We obtained California Cancer Registry data on female diagnoses and treatment from 2012 2017. Our main independent variable was patient race ethnicity, including 6 Dependent variables included time surgical for receipt within 30 90 days diagnosis. We conducted multivariable logistic...
Regeneration of pancreatic β-cell mass benefits both type 1 and 2 diabetic patients. A recent study identified betatrophin as a proliferation factor. However, the expressional regulation remains less defined. In this study, we aimed to clarify expression in obese vs. diabetes model animals. We experimented models, diet-induced-obesity (DIO) mice db/db mice, C57B6 receiving streptozotocin (STZ) or 70% pancreatectomy destroy remove β-cells. Serum levels mRNA expressions liver, white adipose...
Abstract Background The direct detection of drugs and metabolites in urine using a targeted panel offers sensitive specific comparison to the traditional approach drug testing (screen with reflex samples positive results confirmation testing). purpose this study was evaluate changes clinical demand for laboratory provide interpretation patient adherence abstinence, based on reconciling individual medication information provided by clinician. shifts toxicology likely reflect inherent...
Hyperglycemia impairs insulin secretion as well action, being recognized the glucotoxicity that accelerates diabetes. However, mechanism underlying in pancreatic β-cells is not thoroughly understood. alters glucose metabolism within and interstitial conditions around β-cells, including elevated osmolarity increased concentrations of ATP released from overstimulated β-cells. In this study, to explore direct effects these alterations on single isolated rat islets were cultured for 3 days...