A5065631754- Neuroscience and Neuropharmacology Research
- Neurotransmitter Receptor Influence on Behavior
- Neural dynamics and brain function
- Sleep and Wakefulness Research
- Receptor Mechanisms and Signaling
- Memory and Neural Mechanisms
- Neuroscience and Music Perception
- Acupuncture Treatment Research Studies
- Neuroendocrine regulation and behavior
- Schizophrenia research and treatment
- Treatment of Major Depression
- EEG and Brain-Computer Interfaces
- Circadian rhythm and melatonin
- Adipose Tissue and Metabolism
- Sexual function and dysfunction studies
- Urinary Bladder and Prostate Research
- Sexuality, Behavior, and Technology
- Axon Guidance and Neuronal Signaling
- Ion channel regulation and function
- Diverse Music Education Insights
- Creativity in Education and Neuroscience
- Pain Mechanisms and Treatments
- Healthcare and Venom Research
- Neural and Behavioral Psychology Studies
- Technology Assessment and Management
Fukushima Medical University
2010-2025
Imperial Household Agency
1991-1999
Allegheny College
1997
Tohoku University
1988-1990
Phencyclidine (PCP) is a psychotomimetic drug that elicits schizophrenia-like symptoms in healthy persons, and administration of PCP to animals used as pharmacological model schizophrenia. We recently demonstrated systemic rats produces long-lasting activation medial prefrontal cortex (mPFC) neurons with augmentation locomotor activity, whereas direct application mPFC has little effect on their firing activity. These findings suggest PCP-induced elicited mainly via excitatory inputs from...
Subchronic administration of the psychotomimetic drug phencyclidine is known to exacerbate serotonin 5-HT2A receptor-relevant behavioral abnormalities. However, effects subchronic on receptors remain unclear. Here, we investigated binding potential (BPND) in rat brain using positron emission tomography. Adult male Sprague-Dawley rats received intraperitoneal injection either (10 mg/kg) or physiological saline once daily, a total 15 times. tomography scans were performed twice, before and...
Perinatal exposure to epidermal growth factor (EGF) induces various cognitive and behavioral abnormalities after maturation in non-human animals, is used for animal models of schizophrenia. Patients with schizophrenia often display a reduction mismatch negativity (MMN), which stimulus-change specific event-related brain potential. Do the EGF model animals also exhibit MMN as schizophrenic patients do? This study addressed this question verify pathophysiological validity model. Neonatal rats...
Using urethane-anaesthetized rats, the effects of acupunctural stimulation to sacral segment on urinary bladder activity and cortical electroencephalogram (EEG) were examined. The acupuncture suppressed in 36 68 trials. On many occasions (22/36 trials), suppression was accompanied by an increase EEG amplitude. In such cases, power increased all frequency bands after stimulation. same changes could be induced when empty with no contraction. results suggest that affects both sleep-arousal system.
Phenotypic development of neocortical GABA neurons is highly plastic and promoted by various neurotrophic factors such as neuregulin-1. A subpopulation expresses not only neuregulin receptor (ErbB4) but also epidermal growth factor (EGF) (ErbB1) during development, the neurobiological action EGF on this cell population less understood than that Here, we examined effects exogenous immature both in culture vivo explored physiological consequences adults. We prepared low density cultures from...
The cholinergic neurons in the laterodorsal tegmental nucleus (LDT) play a crucial role regulation of rapid eye movement (REM) sleep. Because penile erection occurs during REM sleep, involvement LDT was examined unanesthetized head-restrained rats. To detect erection, corpus spongiosum penis (CSP) pressure measured through telemetric device with simultaneous bulbospongiosum (BS) muscle EMG recording stainless wires. Electrical stimulation and around induced following three CSP patterns: 1)...
Abstract Auditory neurophysiological responses, such as steady-state event-related potential P300/P3, and phase-amplitude coupling, are promising translational biomarkers for schizophrenia, but their molecular underpinning is poorly understood. Focusing on ErbB receptor signals that implicated in both schizophrenia auditory processing/cognition, we explored the causal biological links between these traits with an experimental intervention into rats. We peripherally challenged rat pups one of...