A5060597199- Sleep and Wakefulness Research
- Sleep and related disorders
- Obstructive Sleep Apnea Research
- Circadian rhythm and melatonin
- Restless Legs Syndrome Research
- Sexual function and dysfunction studies
- Neuroscience of respiration and sleep
- Urinary Bladder and Prostate Research
- Hormonal and reproductive studies
- EEG and Brain-Computer Interfaces
- Parkinson's Disease Mechanisms and Treatments
- Heart Rate Variability and Autonomic Control
- Cardiovascular and Diving-Related Complications
- Context-Aware Activity Recognition Systems
- Sleep and Work-Related Fatigue
- Neuroendocrine regulation and behavior
- Dysphagia Assessment and Management
- Asthma and respiratory diseases
- Sexuality, Behavior, and Technology
- Drug-Induced Adverse Reactions
- Non-Invasive Vital Sign Monitoring
- Cardiovascular Health and Disease Prevention
- Respiratory and Cough-Related Research
- Spinal Cord Injury Research
- Machine Learning in Healthcare
University Hospital of Bern
2016-2025
University of Bern
2009-2025
Medical University of Vienna
2025
Sleep Management Institute
2014-2024
SleepMed
2006-2024
Universitätsklinik Balgrist
2024
University Hospital Bonn
2024
Technical University of Munich
2023
Weatherford College
2006-2022
University of Applied Sciences and Arts of Southern Switzerland
2022
Abstract The neuronal network responsible for paradoxical sleep (PS) onset and maintenance has not previously been identified in the rat, unlike cat. To fill this gap, study developed a new technique involving recording of sleep–wake states unanaesthetized head‐restrained rats whilst locally administering pharmacological agents by microiontophoresis from glass multibarrel micropipettes, into dorsal pontine tegmentum combining with functional neuroanatomy. Pharmacological used iontophoretic...
Study Objectives:Polysomnographic study evaluating the efficacy of ropinirole for treatment patients with restless legs syndrome (RLS) suffering from periodic leg movements in sleep (PLMS).
Recent studies fueled doubts as to whether all currently defined central disorders of hypersomnolence are stable entities, especially narcolepsy type 2 and idiopathic hypersomnia. New reliable biomarkers needed, the question arises current diagnostic criteria should be reassessed. The main aim this data-driven observational study was see algorithms would segregate 1 identify more subgrouping individuals without cataplexy with new clinical biomarkers.We used agglomerative hierarchical...
AASM guidelines are the result of decades efforts aiming at standardizing sleep scoring procedure, with final goal sharing a worldwide common methodology. The cover several aspects from technical/digital specifications, e.g., recommended EEG derivations, to detailed rules accordingly age. Automated systems have always largely exploited standards as fundamental guidelines. In this context, deep learning has demonstrated better performance compared classical machine learning. Our present work...
Abstract We assessed the efficacy and tolerability of gabapentin enacarbil in treatment moderate to severe primary restless legs syndrome associated sleep disturbance. This was a multicenter, randomized, double‐blind, placebo‐controlled, 2‐period crossover polysomnography study 1200 mg or placebo taken once daily. Subjects were randomized 1:1 sequence enacarbil:placebo placebo:gabapentin enacarbil, receiving each for 4 weeks. The end point mean change from baseline at weeks 10 (4/10) last...
In the absence of systematic and longitudinal data, this study prospectively assessed both frequency evolution sleep-wake disturbances (SWD) after stroke. 437 consecutively recruited patients with ischemic stroke or transient attack (TIA), characteristics outcome were within 1st week 3.2 ± 0.3 years (M±SD) acute event. SWD by interview questionnaires at 1 3 months as well 2 Sleep disordered breathing (SDB) was respirography in phase repeated one fifth participants year later. Patients (63.8%...
Recent advances in long-term time series forecasting have introduced numerous complex prediction models that consistently outperform previously published architectures. However, this rapid progression raises concerns regarding inconsistent benchmarking and reporting practices, which may undermine the reliability of these comparisons. Our position emphasizes need to shift focus away from pursuing ever-more towards enhancing practices through rigorous standardized evaluation methods. To...
Background: Nocturnal hypoglycemia poses significant risks to individuals with insulin-treated diabetes, impacting health and quality of life. Although continuous glucose monitoring (CGM) systems reduce these risks, their poor accuracy at low levels, high cost, availability limit use. This study examined physiological biomarkers associated nocturnal evaluated the use machine learning (ML) detect during nighttime sleep using data from consumer-grade smartwatches. Methods: analyzed 351 nights...
Together with (physical and mental) exercise, diet, social activities, sleep is a key health behavior that occupies one third of our lives, yet remains neglected. In the first part this review, we present current knowledge on how promotes body, brain, mental, occupational, as well creativity, productivity, well-being. second part, discuss good screening for sleep–wake disorders may improve reduce burden cardiovascular, metabolic cancer. We also review literature measurements Bernese Sleep...
<title>Abstract</title> Recent advancements in artificial intelligence (AI) have significantly improved sleep-scoring algorithms, bringing their performance close to the theoretical limit of approximately 80%, which aligns with inter-scorer agreement levels. While this suggests problem is technically solved, clinical adoption remains challenging due ethical and regulatory requirements for rigorous validation, fairness, human oversight. Existing validation methods, such as Bland-Altman...
BACKGROUND: Thalamic stroke (TS) often presents with complex clinical manifestations, including sleep-wake disturbances, cognitive deficits, and autonomic dysregulation, yet the interaction between these functional alterations remains poorly understood. We aimed to investigate interactions in a case-control lesion study. METHODS: Patients acute TS no-stroke controls were included prospectively this The data collected from June 2020 September 2022 at unit or sleep laboratory of Inselspital...
Objective: The international Swiss Primary Hypersomnolence and Narcolepsy Cohort Study (iSPHYNCS) is a multicenter study aimed at identifying novel biomarkers for central disorders of hypersomnolence (CDH). We analyzed questionnaires metadata to uncover distinct clusters participants explore phenotypic variability within CDH. Methods: Data were collected from 227 patients with CDH 33 healthy controls. Participants completed validated clinical study-specific questions addressing CDH-related...
Despite evidence that sleep-disorders alter sleep-stage dynamics, only a limited amount of these parameters are included and interpreted in clinical practice, mainly due to unintuitive methodologies or lacking normative values. Leveraging the matrix transition proportions, we propose (i) general framework quantify sleep-dynamics, (ii) several novel markers their alterations, (iii) demonstrate our approach using obstructive sleep apnea (OSA), one most prevalent sleep-disorder significant risk...
Penile erections are a characteristic phenomenon of paradoxical sleep (PS), or rapid eye movement sleep. Although the neural mechanisms PS-related unknown, forebrain likely plays critical role (Schmidt et al., 1999). The preoptic area is implicated in both generation and copulatory mechanisms, suggesting it may be primary candidate PS erectile control. Continuous recordings penile erections, body temperature, sleep–wake states were performed before up to 3 weeks after ibotenic acid lesions...