A5036122545- Sleep and Wakefulness Research
- Sleep and related disorders
- Circadian rhythm and melatonin
- Neuroscience and Neuropharmacology Research
- Neuroscience of respiration and sleep
- Regulation of Appetite and Obesity
- Neurotransmitter Receptor Influence on Behavior
- Memory and Neural Mechanisms
- Neuropeptides and Animal Physiology
- Neural dynamics and brain function
- Neuroendocrine regulation and behavior
- Restless Legs Syndrome Research
- Parkinson's Disease Mechanisms and Treatments
- Stress Responses and Cortisol
- Receptor Mechanisms and Signaling
- Obstructive Sleep Apnea Research
- EEG and Brain-Computer Interfaces
- Adipose Tissue and Metabolism
- Hypothalamic control of reproductive hormones
- Photoreceptor and optogenetics research
- Biochemical Analysis and Sensing Techniques
- Pain Mechanisms and Treatments
- Neurobiology and Insect Physiology Research
- Biochemical effects in animals
- Cannabis and Cannabinoid Research
Inserm
2016-2025
Université Claude Bernard Lyon 1
2016-2025
Centre National de la Recherche Scientifique
2016-2025
Centre de Recherche en Neurosciences de Lyon
2016-2025
Réseau d'Allergo-Vigilance
2011-2024
Centre Hospitalier Le Vinatier
2013-2024
Délégation Régionale Auvergne-Rhône-Alpes
2024
Tokyo Institute of Psychiatry
2011
Centre National pour la Recherche Scientifique et Technique (CNRST)
2010
Centre de Gestion Scientifique
2009
Peptidergic neurons containing the melanin-concentrating hormone (MCH) and hypocretins (or orexins) are intermingled in zona incerta, perifornical nucleus lateral hypothalamic area. Both types of have been implicated integrated regulation energy homeostasis body weight. Hypocretin also involved sleep-wake narcolepsy. We therefore sought to determine whether hypocretin MCH express Fos association with enhanced paradoxical sleep (PS or REM sleep) during rebound following PS deprivation. Next,...
Abstract The neuronal network responsible for paradoxical sleep (PS) onset and maintenance has not previously been identified in the rat, unlike cat. To fill this gap, study developed a new technique involving recording of sleep–wake states unanaesthetized head‐restrained rats whilst locally administering pharmacological agents by microiontophoresis from glass multibarrel micropipettes, into dorsal pontine tegmentum combining with functional neuroanatomy. Pharmacological used iontophoretic...
Extracellular electrophysiological recordings in freely moving cats have shown that serotonergic neurons from the dorsal raphe nucleus (DRN) fire tonically during wakefulness, decrease their activity slow wave sleep (SWS), and are nearly quiescent paradoxical (PS). The mechanisms at origin of modulation these still unknown. Here, we show unanesthetized rat iontophoretic application GABA A antagonist bicuculline on induces a tonic discharge SWS PS an increase rate quiet waking. These data...
Paradoxical sleep (PS) is a state characterized by cortical activation, rapid eye movements and muscle atonia. Fifty years after its discovery, the neuronal network responsible for genesis of PS has been only partially identified. We recently proposed that GABAergic neurons would have pivotal role in network. To localize these neurons, we combined immunohistochemical detection Fos with non-radioactive situ hybridization GAD67 mRNA (GABA synthesis enzyme) control rats, rats deprived 72 h...
Abstract We recently determined in rats that iontophoretic application of bicuculline or gabazine [two GABAa antagonists] and kainic acid (a glutamate agonist) the sublaterodorsal nucleus (SLD) induces with a very short latency paradoxical sleep‐like state. From these results, we proposed GABAergic glutamatergic inputs to SLD sleep (PS)‐executive neurons gate onset PS [R. Boissard et al . (2002) Eur. J. Neurosci ., 16, 1959–1973]. therefore decided determine origin non‐GABAergic combining...
Abstract It is well known that noradrenergic locus coeruleus (LC) neurons decrease their activity during slow wave sleep (SWS) and are virtually quiescent paradoxical (PS). has been proposed a GABAergic input could be directly responsible for this sleep‐dependent neuronal inactivation. To test hypothesis, we used new method combining polygraphic recordings, microiontophoresis single‐unit extracellular recordings in unanaesthetized head‐restrained rats. We found iontophoretic application of...
Abstract Using a sensitive double‐immunostaining technique with nonconjugated cholera toxin B subunit (CT) as retrograde tracer, we examined the cells of origin and histochemical nature afferents to cat nucleus reticularis magnocellularis (Mc) medulla oblongata. After injections CT confined Mc, found that major Mc arise from: (1) lateral part bed stria terminalis, anterior commissure, preoptic area, central amygdala, posterior hypothalamus, fields Forel; (2) Edinger‐Westphal nucleus,...
It has been shown that wake (W) and slow wave sleep (SWS) modulate synaptic transmission in neocortical projections. However the impact of paradoxical (PS) quantities on remains unknown. We examined whether PS modulated excitatory expression glutamate receptor subtypes phosphorylated extracellular signal-regulated kinases (p-ERK1/2).PS deprivation (PSD) was carried out with multiple platforms method adult male Sprague-Dawley rats. LTP, late-LTP, were studied dorsal ventral hippocampus...
Study Objectives:To determine whether sublaterodorsal tegmental nucleus (SLD) neurons triggering paradoxical (REM) sleep (PS) are glutamatergic.
SEE SCHENCK AND MAHOWALD DOI101093/AWW329 FOR A SCIENTIFIC COMMENTARY ON THIS ARTICLE: Idiopathic REM sleep behaviour disorder is characterized by the enactment of violent dreams during paradoxical (REM) in absence normal muscle atonia. Accumulating clinical and experimental data suggest that might be due to neurodegeneration glutamate neurons involved located within pontine sublaterodorsal tegmental nucleus. The purpose present work was thus functionally determine first, role nucleus...
Plasticity and cortical activation during REM sleep is shown by a subset of hippocampal neurons.