A5061744472- Restless Legs Syndrome Research
- Sleep and Wakefulness Research
- Sleep and related disorders
- Parkinson's Disease Mechanisms and Treatments
- Circadian rhythm and melatonin
- Obstructive Sleep Apnea Research
- Eating Disorders and Behaviors
- Obesity, Physical Activity, Diet
- Child Nutrition and Feeding Issues
- Dysphagia Assessment and Management
- Neuroscience of respiration and sleep
- Neuroscience and Neuropharmacology Research
- Neurological disorders and treatments
- Schizophrenia research and treatment
- Youth Substance Use and School Attendance
- Sleep and Work-Related Fatigue
- Bipolar Disorder and Treatment
- Diet and metabolism studies
- Pain Management and Opioid Use
- Nutrition and Health in Aging
- Cardiovascular Syncope and Autonomic Disorders
- Heart Rate Variability and Autonomic Control
- Migraine and Headache Studies
- Transcranial Magnetic Stimulation Studies
- Nutritional Studies and Diet
Massachusetts General Hospital
2016-2025
Harvard University
2015-2024
Brigham and Women's Hospital
2008-2022
Gachon University
2022
Seoul National University Bundang Hospital
2022
Ewha Womans University
2022
Wayne State University
2020
Michigan Medicine
2020
Vanderbilt University Medical Center
2017
Pennsylvania State University
2017
We validated actigraphy for detecting sleep and wakefulness versus polysomnography (PSG).
We evaluated the cross-sectional association between restless legs syndrome (RLS) and prevalent cardiovascular disease (CVD) in a large community-based sample of middle-aged elderly subjects.This is observational study 1,559 men 1,874 women (mean age 67.9 years) who were enrolled Sleep Heart Health Study, consequences sleep-disordered breathing. RLS was defined by positive responses on self-administered questionnaire to four diagnostic criteria, with symptoms occurring at least five times...
A Task Force was established by the International Restless Legs Syndrome Study Group (IRLSSG) in conjunction with European (EURLSSG) and RLS Foundation (RLS-F) to develop evidence-based consensus-based recommendations for prevention treatment of long-term pharmacologic dopaminergic-induced augmentation restless legs syndrome/Willis–Ekbom disease (RLS/WED). The made following recommendations: As a means prevent augmentation, medications such as α2δ ligands may be considered initial RLS/WED...
Brain iron deficiency has been implicated in the pathophysiology of RLS, and current RLS treatment guidelines recommend when peripheral levels are low. In order to assess evidence on oral intravenous (IV) periodic limb movement disorder (PLMD) adults children, International Restless Legs Syndrome Study Group (IRLSSG) formed a task force review these studies provide evidence-based consensus for adults, PLMD children.A literature search was performed identify papers appearing MEDLINE from its...
To determine current patterns and predictors of use prescription medications commonly used for insomnia (MCUFI) in the U.S.Cross-sectional study.National Health Nutrition Examination Survey, 1999-2010.32,328 noninstitutionalized community-dwelling U.S. adults.N/A.WE DEFINED MCUFI USE AS OF ANY THE FOLLOWING MEDICATIONS IN PRECEDING MONTH: benzodiazepine receptor agonists (eszopiclone, zaleplon, zolpidem, estazolam, flurazepam, quazepam, temazepam, triazolam), barbiturates (amobarbital,...
A Task Force was established by the International Restless Legs Syndrome Study Group (IRLSSG) to develop evidence-based and consensus-based recommendations for long-term pharmacologic treatment of restless legs syndrome/Willis–Ekbom disease (RLS/WED). The reviewed results all studies RLS/WED treatments with durations 6 months or longer presented at meetings over past 2 years, posted on Web sites pharmaceutical companies, published in peer-reviewed journals, asking questions, "What is...
Dopaminergic medications relieve symptoms of the restless legs syndrome (RLS) but have potential to cause iatrogenic worsening (augmentation) RLS with long-term treatment. Pregabalin may be an effective alternative.In this 52-week, randomized, double-blind trial, we assessed efficacy and augmentation in patients who were treated pregabalin as compared placebo pramipexole. Patients randomly assigned receive 52 weeks treatment at a dose 300 mg per day or pramipexole 0.25 0.5 12 followed by 40...
To make evidence-based recommendations regarding restless legs syndrome (RLS) management in adults.
To review the literature on restless legs syndrome (RLS), periodic limb movements in sleep, and depression. Literature review. N/A. We conducted a comprehensive of searching for publications that included data depression or antidepressants RLS sleep. Sixtytwo relevant references were found reviewed. Four population-based studies 9 clinical reported significantly higher rates symptoms individuals with than controls. Conversely, prevalence patients presenting was as elevated 2 studies....
Rapid eye movement (REM) sleep behavior disorder (RBD) is generally observed in older men and individuals with specific neurologic diseases. There are case reports of RBD taking serotonergic antidepressants. Our objective was to assess electromyogram (EMG) activity during REM antidepressants a matched control group not on such medication.Chart review clinical polysomnographic data.Sleep laboratory affiliated general hospital.15 subjects antidepressant 15 age-matched medication.Submental...
Periodic leg movements of sleep are currently subdivided based upon whether or not they associated with EEG arousal. "Autonomic" arousals, characterized by elevations in heart rate and blood pressure without AASM-defined changes, have been daytime somnolence experimental protocols. In this study, we will describe the response to periodic sleep, both arousals.Heart was averaged for each ten cardiac cycles before, after, onset individual occurring non-REM eight patients Limb Movement Disorder...
To evaluate the efficacy and safety of pramipexole in patients with moderate to severe restless legs syndrome (RLS) METHODS: The authors conducted a 12-week, double-blind, randomized, placebo-controlled trial fixed doses (0.25, 0.50, 0.75 mg/day). Patients (N = 344) were up-titrated their randomized dose over 3 weeks. primary endpoints patient ratings symptom severity on International RLS Study Group Rating Scale (IRLS) clinician improvement Clinical Global Impressions-Improvement (CGI-I)...
Both basic and clinical data suggest a potential significant role for GABA in the etiology maintenance of primary insomnia (PI). Proton magnetic resonance spectroscopy (1H-MRS) can non-invasively determine levels human brain. Our objective was to assess unmedicated individuals with PI, using 1H-MRS.Matched-groups, cross-sectional study conducted at two university-based hospitals.Sixteen non-medicated (8 women) PI (mean age = 37.3 +/- 8.1) 16 (7 well-screened normal sleepers 37.6 4.5).PI...