A5071094667- Memory and Neural Mechanisms
- Neuroendocrine regulation and behavior
- Neural dynamics and brain function
- Neuroscience and Neuropharmacology Research
- Neurogenesis and neuroplasticity mechanisms
- Neuroinflammation and Neurodegeneration Mechanisms
- Stress Responses and Cortisol
- Biochemical Analysis and Sensing Techniques
- Axon Guidance and Neuronal Signaling
- Neuroscience and Neural Engineering
- Sleep and Wakefulness Research
- Olfactory and Sensory Function Studies
- Neuroscience and Music Perception
- Autism Spectrum Disorder Research
- Photoreceptor and optogenetics research
- Neuroscience, Education and Cognitive Function
- Empathy and Medical Education
- Mental Health and Psychiatry
- Nicotinic Acetylcholine Receptors Study
- Sleep and related disorders
- Circadian rhythm and melatonin
- Bullying, Victimization, and Aggression
- Health Policy Implementation Science
- Proteoglycans and glycosaminoglycans research
- Vagus Nerve Stimulation Research
Max Planck Institute of Psychiatry
2021-2024
Max Planck Institute of Neurobiology
2017-2023
Harvard University
2009-2014
Friedrich Miescher Institute
2006-2009
In adult animals, fear conditioning induces a permanent memory that is resilient to erasure by extinction. contrast, during early postnatal development, extinction of conditioned leads erasure, suggesting memories are actively protected in adults. We show here this protection conferred extracellular matrix chondroitin sulfate proteoglycans (CSPGs) the amygdala. The organization CSPGs into perineuronal nets (PNNs) coincided with developmental switch resilience. adults, degradation PNNs...
Abstract One unifying explanation for the complexity of Autism Spectrum Disorders (ASD) may lie in disruption excitatory/inhibitory (E/I) circuit balance during critical periods development. We examined whether Parvalbumin (PV)-positive inhibitory neurons, which normally drive experience-dependent refinement (Hensch Nat Rev Neurosci 6:877–888, 1), are disrupted across heterogeneous ASD mouse models. performed a meta-analysis PV expression previously published models and analyzed two...
Understanding the neurobiological underpinnings of emotion relies on objective readouts emotional state an individual, which remains a major challenge especially in animal models. We found that mice exhibit stereotyped facial expressions response to emotionally salient events, as well upon targeted manipulations emotion-relevant neuronal circuits. Facial were classified into distinct categories using machine learning and reflected changing intrinsic value same sensory stimulus encountered...
The insular cortex (IC) plays key roles in emotional and regulatory brain functions is affected across psychiatric diseases. However, the brain-wide connections of mouse IC have not been comprehensively mapped. Here, we traced whole-brain inputs outputs its rostro-caudal extent. We employed cell-type-specific monosynaptic rabies virus tracings to characterize afferent onto either excitatory or inhibitory neurons, adeno-associated viral label efferent axons. While connectivity between other...
How does the brain maintain fear within an adaptive range? We found that insular cortex acts as a state-dependent regulator of is necessary to establish equilibrium between extinction and maintenance memories in mice. Whereas responsiveness fear-evoking cues increased with their certainty predict harm, this activity was attenuated through negative bodily feedback arose from heart rate decelerations during freezing. Perturbation body-brain communication by vagus nerve stimulation disrupted...
Neuroscientists studying the neural correlates of mouse behavior often lack access to brain-wide activity patterns elicited during a specific task interest. Fortunately, large-scale imaging is becoming increasingly accessible thanks modalities such as Ca2+ and functional ultrasound (fUS). However, these other techniques involve challenging cranial window procedures are difficult combine with neuroscience tools. We address this need an open-source 3D-printable implant-the COMBO (ChrOnic...
Abstract The insular cortex (IC) plays key roles in emotional and regulatory brain functions is affected across psychiatric diseases. However, the brain-wide connections of mouse IC have not been comprehensively mapped. Here we traced whole-brain inputs outputs its rostro-caudal extent. We employed cell-type specific monosynaptic rabies virus tracings to characterize afferent onto either excitatory or inhibitory neurons, adeno-associated viral label efferent axons. While connectivity between...
ABSTRACT Neuroscientists studying the neural correlates of mouse behavior often lack access to brain-wide activity patterns elicited during a specific task interest. Fortunately, large-scale imaging is becoming increasingly accessible thanks modalities such as Ca 2+ and functional ultrasound (fUS). However, these other techniques involve challenging cranial window procedures, are difficult combine with neuroscience tools. We address this need an open-source 3D-printable implant - COMBO ( C...