A5027880928- Vestibular and auditory disorders
- Hearing, Cochlea, Tinnitus, Genetics
- Ophthalmology and Eye Disorders
- Olfactory and Sensory Function Studies
- Glaucoma and retinal disorders
- Ear Surgery and Otitis Media
- Head and Neck Cancer Studies
- Sleep and Wakefulness Research
- Salivary Gland Tumors Diagnosis and Treatment
- Ear and Head Tumors
- Head and Neck Surgical Oncology
- Tracheal and airway disorders
- Cerebral Venous Sinus Thrombosis
- Hearing Loss and Rehabilitation
- Mast cells and histamine
- Neuroscience and Neuropharmacology Research
- Sinusitis and nasal conditions
- Renal Diseases and Glomerulopathies
- Ocular Surface and Contact Lens
- Cancer Immunotherapy and Biomarkers
- Dysphagia Assessment and Management
- Allergic Rhinitis and Sensitization
- Neuroendocrine regulation and behavior
- Facial Nerve Paralysis Treatment and Research
- Circadian rhythm and melatonin
Niigata University
2016-2025
Niigata University Medical and Dental Hospital
2018-2024
National Hospital Organization
2012-2024
Fukuyama Cardiovascular Hospital
2012-2024
Registered Nurses' Association of Ontario
2023
Osaka University
2006-2022
Osaka National Hospital
2013-2016
Kangbuk Samsung Hospital
2016
Sungkyunkwan University
2016
Karl Landsteiner University of Health Sciences
2016
This paper presents diagnostic criteria for persistent postural-perceptual dizziness (PPPD) to be included in the International Classification of Vestibular Disorders (ICVD).The term PPPD is new, but disorder not.Its were derived by expert consensus from an exhaustive review 30 years research on phobic postural vertigo, space-motion discomfort, visual and chronic subjective dizziness.PPPD manifests with one or more symptoms dizziness, unsteadiness, non-spinning vertigo that are present most...
The hippocampus is thought to be important for spatial representation processes that depend on the integration of both self-movement and allocentric cues. vestibular system a particularly source information may contribute this representation. To test hypothesis provides hippocampus, rats were given either bilateral labyrinthectomy (n = 6) or sham surgery 6), at least 60 d after hippocampal CA1 neurons recorded extracellularly while animals foraged freely in an open arena. Recorded cells...
To establish a questionnaire to diagnose and assess the severity of persistent postural-perceptual dizziness (PPPD).Retrospective chart review.Tertiary referral center.Fifty PPPD patients 50 consecutive control with other vestibular disorders.Patients answered questions on three exacerbating factors (upright posture/walking, movement, visual stimulation), each factor was evaluated using four scoring from 0 (none) 6 (unbearable). Somatic psychological distress by Visual Analog Scale (VAS)...
Abstract NRF2 is a transcription factor responsible for antioxidant stress responses that usually regulated in redox‐dependent manner. p62 bodies formed by liquid–liquid phase separation contain Ser349‐phosphorylated p62, which participates the redox‐independent activation of NRF2. However, regulatory mechanism and physiological significance phosphorylation remain unclear. Here, we identify ULK1 as kinase p62. colocalizes with bodies, directly interacting ULK1‐dependent allows KEAP1 to be...
The hippocampus has a major role in memory for spatial location. Theta is rhythmic hippocampal EEG oscillation that occurs at approximately 8 Hz during voluntary movement and may have some encoding information. We investigated whether, as part of this process, theta might be influenced by self-movement signals provided the vestibular system. effects bilateral peripheral lesions, made > or = 60 days prior to recording, were assessed freely moving rats. Power spectral analysis revealed...
For more than a decade, evidence from animal studies has suggested that damage to the vestibular system leads deficits in spatial navigation which are indicative of impaired learning and memory. More recently, direct emerged demonstrate humans with disorders exhibit range cognitive not just nature, but also include non-spatial functions such as object recognition Vestibular dysfunction been shown adversely affect attentional processes increased demands can worsen postural sway associated...
Objective The aim of this study was to profile and compare the middle ear microbiomes human subjects with without chronic otitis media. Study Design Prospective multicenter cohort study. Methods All consecutive patients undergoing tympanoplasty surgery for media or conditions other than were recruited. Sterile swab samples collected from mucosa during surgery. variable region 4 16S rRNA gene in each sample amplified using region‐specific primers adapted Illumina MiSeq sequencer (Illumina,...
Meniere’s disease, characterised by episodic vertigo, fluctuating hearing loss and tinnitus, can occur under conditions of stress. Its pathology was first revealed to be inner ear hydrops through temporal bone studies in 1938. Although its pathogenesis has been proposed a disorder water transport the ear, subsequently, it remains unsolved, until now. A recent study that both plasma stress hormone, vasopressin (pAVP) receptor, V2 (V2R) expression endolymphatic sac were significantly higher...
Meniere's disease is peculiar to humans and characterised by episodic vertigo, fluctuating hearing loss tinnitus, attacks of the affliction occurring under conditions stress. Its pathology was first revealed be inner ear hydrops through temporal bone studies in 1938. Although subsequently proposed as a disorder water metabolism ear, its pathogenesis remains unsolved. The present study aimed assess link between vasopressin, an anti-diuretic stress hormone with potential role fluid...
To search for prognostic predictors and reexamine the usefulness of electroneurography (ENoG) in predicting prognosis peripheral facial palsy using statistical methods.Prospective study.Tertiary referral center.Consecutive 142 patients with Bell's 26 Ramsay Hunt syndrome treated steroid plus antiviral agents.Multivariate analysis was used to identify which factors, including Yanagihara grading score ENoG, predict better recovery. Receiver operating characteristic (ROC) curves were...
In this study, we examined the effects of sensory inputs visual-vestibulosomatosensory conflict induced by virtual reality (VR) on subjective dizziness, posture stability and visual dependency postural control in humans. Eleven healthy young volunteers were immersed two different VR conditions. condition, subjects walked voluntarily with background images interactive computer graphics proportionally synchronized to their walking pace. kept still, but that experienced condition presented. The...
Immunoglobulin A nephropathy (IgAN) is the most prevalent primary chronic glomerular disease, in which mucosal immune response elicited particularly tonsils or intestine has been estimated to be involved development of disease. To explore relationship between IgAN and bacterial flora tonsils, we conducted a comprehensive microbiome analysis. We enrolled 48 patients, 21 recurrent tonsillitis (RT) patients without urine abnormalities 30 children with tonsillar hyperplasia (TH) who had...
Persistent postural-perceptual dizziness (PPPD) is a chronic neuro-otologic disorder characterized by vestibular symptoms such as dizziness, unsteadiness, or non-spinning vertigo. Its pathophysiology presumed to involve sensory reweighting visual/somatosensory sensations for maintaining spatial orientation. Serotonergic antidepressants are major treatment option PPPD. However, no reports describe the long-term outcomes of these therapeutic agents in patients with Therefore, we evaluated...
In order to investigate whether bilateral peripheral vestibular lesions cause long-term impairment of spatial learning, rats were tested in a reference memory radial arm maze learning task at least 5 weeks following labyrinthectomy (BL) or sham control lesion. All reached criterion (i.e., 1 error less, averaged across 7 trials for 3 consecutive days training) but only 4 the 8 BL had by day 21 training sessions. The more quickly than lesioned (Control, 7.0 +/- 0.63 days, Lesioned, 15.8 1.4...
Abstract: In order to elucidate the modulatory role of histaminergic neural system in cholinergic system, acetylcholine release from CA1‐CA3 region hippocampus anesthetized rats was studied by an vivo microdialysis method coupled with HPLC‐electrochemical detection. The mean value for basal 0.98 β 0.04 pmol/20 min. increased 172% level when electrical stimulation at 200 μA applied tuberomammillary nucleus. An administration α‐fluoromethylhistidine (100 mg/kg i.p.) blocked electrically evoked...
1. The effects of electrical stimulation to the round window inner ear and caloric vestibular on in vivo release acetylcholine (ACh) from rat hippocampus were investigated, using brain microdialysis coupled with high performance liquid chromatography-electrochemical detection. 2. Hippocampal ACh was increased 152% basal by 1-Hz, 200-ms, 500-microA window. This effect dependent current intensity. 3. Microinjection 6,7-dinitroquinoxaline-2,3-dione (DNQX) (10 nmol/0.2 microliter), an antagonist...
A prospective, open-label clinical trial was conducted for two aims: first, to evaluate the role of fluvoxamine, one selective serotonin reuptake inhibitors, in treatment dizziness first time and investigate its effective mechanisms. Second, test hypothesis that patients without abnormal neuro-otologic findings would be induced by psychiatric disorders rather than unnoticed diseases. Nineteen with diseases (Group I) 22 whom standard vestibular tests revealed no II) were treated fluvoxamine...
To investigate the occurrence rate, prognosis, and inner ear abnormality in intractable benign paroxysmal positioning vertigo (BPPV).A prospective study.Tertiary referral university hospital.Intractable BPPV was defined case of either a persistent nystagmus or frequent relapse each lasting more than 1 year after initial diagnosis.T2-weighted 3-dimensional fast imaging employing steady-state acquisition sequences magnetic resonance (MRI) were reconstructed 3-dimensionally for 13 patients 14...