A5080923776- Hormonal Regulation and Hypertension
- Adrenal and Paraganglionic Tumors
- Adrenal Hormones and Disorders
- Carbon Nanotubes in Composites
- Graphene research and applications
- Cardiovascular, Neuropeptides, and Oxidative Stress Research
- Diamond and Carbon-based Materials Research
- Neurogenesis and neuroplasticity mechanisms
- Respiratory and Cough-Related Research
- Ocular Diseases and Behçet’s Syndrome
- Asthma and respiratory diseases
- Diet and metabolism studies
- Pluripotent Stem Cells Research
- Autism Spectrum Disorder Research
- Catalytic Processes in Materials Science
- Tuberculosis Research and Epidemiology
- Workplace Health and Well-being
- Mycobacterium research and diagnosis
- Otitis Media and Relapsing Polychondritis
- Dysphagia Assessment and Management
- Employment and Welfare Studies
- Pharmacy and Medical Practices
- Diagnosis and treatment of tuberculosis
- Electrolyte and hormonal disorders
- Catalysts for Methane Reforming
International University of Health and Welfare
2017-2025
Saitama Medical University
2020-2025
Hitachi (Japan)
2016-2025
Saitama Medical University Hospital
2023-2024
The University of Tokyo
2006-2024
NIHR Leicester Biomedical Research Centre
2024
British Heart Foundation
2024
University of Leicester
2024
Yokohama City University Hospital
2024
Yokohama City University
2024
There have been several clinical studies examining the factors associated with cardiovascular disease (CVD) in patients primary aldosteronism (PA); however, their results left it unclear whether CVD is affected by plasma aldosterone concentration or hypokalemia. We assessed PA database established multicenter JPAS (Japan Primary Aldosteronism Study) and compared prevalence of among that age-, sex-, blood pressure-matched essential hypertension participants a general population cohort. also...
Previous energetic considerations have led to the belief that carbon nanotubes (CNTs) of $4\text{ }\text{ }\AA{}$ in diameter are smallest stable CNTs. Using high-resolution transmission electron microscopy, we find a $3\text{ CNT can be grown inside multiwalled nanotube. Density functional calculations indicate is armchair $\mathrm{CNT}(2,2)$ with radial breathing mode at $787\text{ }{\mathrm{cm}}^{\ensuremath{-}1}$. Each end capped by half ${\mathrm{C}}_{12}$ cage (hexagonal prism)...
Dehydroepiandrosterone (DHEA) is the most abundant adrenal steroid hormone in humans. Although it well established that DHEA serves as an intermediate sex synthesis, recent studies mice suggest may also be a physiologic regulator of IL2 secretion. To explore effect on human immune system, T lymphocytes from healthy adults were exposed to followed by stimulation with mitogens or antigen. Upon activation variety stimuli, cells pretreated 10−8 10−11 M produced significantly greater amounts and...
Gut microbiota compositional alteration may have an association with immune dysfunction in patients Behcet's disease (BD). We conducted a fecal metagenomic analysis of BD patients. analyzed obtained from 12 and normal individuals by sequencing 16S ribosomal RNA gene. compared the relative abundance bacterial taxa. Direct comparison taxa demonstrated that genera Bifidobacterium Eggerthella increased significantly Megamonas Prevotella decreased individuals. A linear discriminant showed phylum...
OBJECTIVE To investigate the prevalence and causes of diabetes in patients with primary aldosteronism (PA) a multi-institutional cohort study Japan. RESEARCH DESIGN AND METHODS The was determined 2,210 PA (diagnosed or glycated hemoglobin [HbA1c] ≥6.5% [≥48 mmol/mol]; NGSP) compared that Japanese general population according to age sex. In 1,386 clear laterality (unilateral bilateral), effects plasma aldosterone concentration (PAC), hypokalemia (<3.5 mEq/L), suspected subclinical...
<i>Background:</i> Pneumonia is the reported cause of death a high proportion Alzheimer’s disease (AD) patients. <i>Objectives:</i> This study assessed swallowing function to explore potential risk factors aspiration pneumonia in AD <i>Methods:</i> Data were gathered on 121 patients (mean age 78.2, SD 7.5, male/female ratio = 48/73) treated two psychiatric hospitals. Multiple logistic regression analysis was used estimate odds ratios for pneumonia. The...
Excessive T helper type 1 (Th1) cell activity has been reported in Behçet's disease (BD). Recently, association of Th17 cells with certain autoimmune diseases was reported, and we thus investigated circulating BD. CD4(+) CD45RO(-) (naive) were cultured Th0-, Th1-, Th2- Th17-related cytokines antibodies, their mRNA studied by real-time polymerase chain reaction (PCR). When naive Th1- cytokines, interferon (IFN)-γ interleukin (IL)-17 up-regulated, respectively, BD patients. Naive a...
Although confirmatory testing to verify aldosterone excess is a key step in the diagnosis of primary aldosteronism (PA), there no consensus as whether it always needed and which tests need be performed.The objective this study was investigate diagnostic significance PA.In group A, 120 hypertensive patients who had positive case detection using renin ratio (ARR) were subjected at least one test: captopril challenge test (CCT), furosemide upright (FUT), or saline infusion (SIT). Among 57...
The number of centers with established adrenal venous sampling (AVS) programs for the subtype diagnosis primary aldosteronism (PA) is limited. Aim was to develop an algorithm AVS based on prediction by computed tomography (CT) and serum potassium. A multi-institutional retrospective cohort study in Japan. total 1591 patients PA were classified into four groups according CT findings potassium status. Subtype determined AVS. Prediction value combination status diagnosis. percentages unilateral...
Objective The aim of this study was to profile and compare the middle ear microbiomes human subjects with without chronic otitis media. Study Design Prospective multicenter cohort study. Methods All consecutive patients undergoing tympanoplasty surgery for media or conditions other than were recruited. Sterile swab samples collected from mucosa during surgery. variable region 4 16S rRNA gene in each sample amplified using region‐specific primers adapted Illumina MiSeq sequencer (Illumina,...
Brain‐derived neurotrophic factor (BDNF) is involved in the survival, development, and synaptic plasticity of neurons. BDNF believed to be associated with pathophysiology psychiatric disorders. Several studies have suggested relevance DNA methylation its promoter region depression. Here, we report different statuses groups depressive scores or undergoing levels job‐stress. samples were extracted from saliva 774 Japanese workers, status was determined using Illumina HumanMethylation 450 K...
Relapsing polychondritis (RP) is an inflammatory disease of unknown causes, characterized by recurrent inflammation in cartilaginous tissues the whole body. Recently, researchers have reported that, mouse experiments, altered gut microbe-dependent T cell differentiation occurred associated lymphoid tissues. Here, we investigated whether microbe alteration existed, and if so, affected peripheral patients with RP. In analysis microbiota, found increased annotated species numbers RP compared...
Summary Context The current Endocrine Society Guideline suggests that patients aged <35 years with marked primary aldosteronism ( PA ) and unilateral adrenal lesions on computed tomography CT scan may not need vein sampling AVS before proceeding to adrenalectomy. This suggestion is, however, based the data from only one report in literature. Objective We sought determine accuracy of findings young who had disease hypokalaemia elevation aldosterone. Design retrospectively studied 358 (n =...
Recently, the relationship between primary aldosteronism (PA) and various metabolic disorders, including obesity, diabetes mellitus, dyslipidemia, has been discussed. However, in PA, aldosterone-producing adenoma (APA) idiopathic hyperaldosteronism (IHA) have different etiologies. Our objectives were to clarify differences obesity disorders APA IHA gain insight pathogenesis of IHA. This is a retrospective cross-sectional study. We assessed PA database established by multicenter Japan Primary...
A subtype prediction score for primary aldosteronism has not yet been developed and validated using a large dataset. This study aimed to develop validate new compare it with existing scores multicenter database.In total, 1936 patients were randomly assigned the development validation datasets, constituting 1290 646 patients, respectively. Three generated or without confirmatory tests, logistic regression analysis. In dataset, compared receiver operating characteristic curve, net...
Objectives: Current clinical guidelines of primary aldosteronism recommend adrenalectomy (AdX) for unilateral based on the studies showing potential superiority AdX over medical treatment. However, since most medically treated cases consisted bilateral and all surgically aldosteronism, different subtype could be a bias their effects. This study compared effects therapy in patients with confirmed by adrenal vein sampling. Methods: Of 339 Japan Primary Pldosteronism Study data base, treatment...
Adrenal vein sampling (AVS) is the standard criterion for subtype diagnosis in primary aldosteronism (PA). Although lateralized index (LI) ≥4 after cosyntropin stimulation commonly recommended cut-off unilateral aldosterone hypersecretion, many of referral centres world use LI <4 without sufficient evidence its diagnostic accuracy.The aim study was to establish significance contralateral (CL) suppression patients with AVS.A retrospective multicentre conducted Japan. Of 124 PA subjected...
Primary aldosteronism causes renal structural damage after glomerular hyperfiltration, and primary aldosteronism-specific treatment leads to an acute fall in estimated filtration rate (eGFR). We investigated whether this change affected the long-term eGFR slope a retrospective cohort from multicenter Japan Aldosteronism Study. allocated patients with adrenalectomy (n=202) MR (mineralocorticoid receptor) antagonist (n=303) groups based on their history analyzed association between initial...
Abstract Objective Primary aldosteronism (PA) is one of the most frequent causes secondary hypertension. Although clinical practice guidelines recommend a diagnostic process, details steps remain incompletely standardized. Design In present SCOT-PA survey, we have investigated diversity approaches utilized for each step in different expert centers through survey using Google questionnaires. A total 33 from 3 continents participated. Results We demonstrated prominent conditions blood...