A5048212731- Vestibular and auditory disorders
- Head and Neck Cancer Studies
- Hearing, Cochlea, Tinnitus, Genetics
- Head and Neck Surgical Oncology
- Ophthalmology and Eye Disorders
- Voice and Speech Disorders
- Sinusitis and nasal conditions
- Dysphagia Assessment and Management
- Cancer Diagnosis and Treatment
- Glaucoma and retinal disorders
- Galectins and Cancer Biology
- Tracheal and airway disorders
- Ear Surgery and Otitis Media
- Ear and Head Tumors
- Phonetics and Phonology Research
- Salivary Gland Tumors Diagnosis and Treatment
- Allergic Rhinitis and Sensitization
- Peptidase Inhibition and Analysis
- Cerebral Venous Sinus Thrombosis
- Asthma and respiratory diseases
- Oral and Maxillofacial Pathology
- Lung Cancer Treatments and Mutations
- Hearing Loss and Rehabilitation
- Bone Tumor Diagnosis and Treatments
- Crystallization and Solubility Studies
Osaka University
2016-2025
Osaka University Hospital
2012-2025
RELX Group (Netherlands)
2023
Takeda (United States)
2022
Osaka National Hospital
2022
Suita Municipal Hospital
2010-2021
Ministry of Health Labour and Welfare
2014
In-Q-Tel
2014
Ikeda Municipal Hospital
2013
Tokushima University
2011
The causality and pathogenic mechanism of microbiome composition remain elusive in many diseases, including autoimmune diseases such as rheumatoid arthritis (RA). This study aimed to elucidate gut microbiome's role RA pathology by a comprehensive metagenome-wide association (MWAS).We conducted MWAS the Japanese population (ncase=82, ncontrol=42) using whole-genome shotgun sequencing high depth (average 13 Gb per sample). Our consisted three major bioinformatic analytic pipelines...
Galectin-3, a β-galactoside-binding protein, is implicated in cell growth, adhesion, differentiation, and tumor progression by interactions with its ligands. Recent studies have revealed that galectin-3 suppresses apoptosis anoikis contribute to survival during metastatic cascades. Previously, it has been shown human undergoes post-translational signaling modification of Ser<sup>6</sup> phosphorylation acts as an "on/off" switch for sugar-binding capability. We questioned whether required...
Galectin-3 (Gal-3), a member of the beta-galactoside binding protein family containing NWGR antideath motif Bcl-2 family, is involved in various aspects cancer progression. Previously, it has been shown that antiapoptotic activity Gal-3 regulated by phosphorylation at Ser(6) casein kinase 1 (CK1). Here we questioned how regulates function. We have generated serine-to-alanine (S6A) and serine-to-glutamic acid (S6E) mutants transfected them into BT-549 human breast carcinoma cell line, which...
The clinical significance of human papillomavirus (HPV) in neck node metastasis from cancer unknown primary (CUP) is not well established. We aimed to address the relationship HPV status between and tumor, also relevance regarding radiographically detected cystic head squamous cell carcinoma (HNSCC) CUP. DNA was examined 68 matched pairs 27 CUPs. In surgically treated CUPs, p16 immunohistochemically. When tonsillectomy proved occult tonsillar CUP, were primary. Cystic on contrast-enhanced...
We aimed to reveal the prevalence and pattern of human papillomavirus ( HPV ) infection p53 mutations among Japanese head neck squamous cell carcinoma HNSCC patients in relation clinicopathological parameters. Human DNA were examined 493 s its subset 283 s. Oropharyngeal was more frequently ‐positive than non‐oropharyngeal (34.4% vs 3.6%, P < 0.001), 16 accounted for 91.1% tumors. In oropharyngeal carcinoma, which showed an increasing trend over time inversely correlated with tobacco...
The incidence of severe mucositis in the oral cavity, pharynx and larynx is high among patients with head neck cancer (HNC) receiving chemoradiotherapy (CRT), resulting significant pain impairment quality life. present study investigated whether L-glutamine (glutamine) decreases severity induced by CRT. This double-blind, randomized, placebo-controlled trial included 40 untreated squamous cell carcinoma nasopharynx, oropharynx, hypopharynx or larynx. Patients received 66 70 Gy total...
Objective Alteration of the gut microbiome has been linked to pathogenesis systemic lupus erythematosus (SLE). However, a comprehensive view in SLE and its interaction with host remains be revealed. This study aimed reveal SLE-associated changes by metagenome-wide association (MWAS) followed integrative analysis. Methods We performed MWAS based on shotgun sequencing microbial DNA from Japanese individuals ( N case =47, control =203). integrated result genome-wide (GWAS) data plasma...
Abstract Human DNA present in faecal samples can result a small number of human reads gut shotgun metagenomic sequencing data. However, it is presently unclear how much personal information be reconstructed from such reads, and this has not been quantitatively evaluated. Such quantitative evaluation necessary to clarify the ethical concerns related data sharing enable efficient use genetic stool samples, as for research forensics. Here we used genomic approaches reconstruct metagenomes 343...
The <sup>18</sup>F-labeled fibroblast activation protein inhibitor (FAPI) [<sup>18</sup>F]FAPI-74 has the benefit of a higher synthetic yield and better image resolution than <sup>68</sup>Ga-labeled FAPI. We preliminarily evaluated diagnostic performance PET in patients with various histopathologically confirmed cancers or suspected malignancies. <b>Methods:</b> enrolled 31 (17 men 14 women) lung cancer (<i>n</i> = 7), breast 5), gastric pancreatic 3), other benign tumors 6). Twenty-seven...
BACKGROUND Galectin-3 is a β-galactoside-binding protein that has been reported to be expressed preferentially in thyroid malignancies. The current study was designed substantiate this finding further and establish presurgical diagnostic modality of differentiating between benign malignant neoplasms by analyzing galectin-3 expression fine-needle aspirates. METHODS examined immunohistochemically total 172 specimens: 45 primary 20 metastatic papillary carcinomas, 8 2 follicular 5 3 anaplastic...
Abstract Studies of CD95 (APO-1/Fas), a member the death receptor family, have revealed that it is involved in two primary apoptotic signaling pathways, one regulated by large amount active caspase-8 (type I) formed at death-inducing complex and other apoptogenic activity mitochondria II). To date, still unclear which pathway will be activated response to an insult. Here, we demonstrate antiapoptotic molecule galectin-3, contains four amino acid-anti-death-motif (NWGR) conserved BH1 domain...
Cancer stem cells (CSCs) are responsible for treatment failure. However, their identification and roles in resistance not well established head neck squamous cell carcinoma (HNSCC). Three HNSCC lines (FaDu, Detroit562 BICR6) were treated with cisplatin or radiation. Cell surface antigens analysed by LyoPlate, a novel antigen array. The expression levels of highly expressed after treatments further compared between cisplatin-resistant its parental line. Association the candidate CSCs...
Recent studies have shown that cancer immunotherapy could be a promising therapeutic approach for the treatment of cancer. In present study, to identify novel tumor-associated antigens (TAAs), proteins expressed in panel cells were serologically screened by immunoblot analysis and eukaryotic elongation factor 2 (eEF2) was identified as an antigen recognized IgG autoantibody sera from group patients with head neck squamous cell carcinoma (HNSCC) or colon Enzyme-linked immunosorbent assay...