A5039983689- Head and Neck Cancer Studies
- Galectins and Cancer Biology
- Cancer Diagnosis and Treatment
- Head and Neck Surgical Oncology
- Inflammatory Biomarkers in Disease Prognosis
- Salivary Gland Tumors Diagnosis and Treatment
- Dysphagia Assessment and Management
- Nutrition and Health in Aging
- Oral health in cancer treatment
- Ear and Head Tumors
- Lung Cancer Treatments and Mutations
- Cancer Immunotherapy and Biomarkers
- Tracheal and airway disorders
- Signaling Pathways in Disease
- Voice and Speech Disorders
- Toxin Mechanisms and Immunotoxins
- Thyroid Cancer Diagnosis and Treatment
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Cancer Genomics and Diagnostics
- Thyroid and Parathyroid Surgery
- RNA modifications and cancer
- Infectious Diseases and Tuberculosis
- Sarcoma Diagnosis and Treatment
- Medical Imaging Techniques and Applications
- Lung Cancer Research Studies
Osaka University
2014-2025
Osaka Prefectural Medical Center
2015-2023
Osaka Police Hospital
2022-2023
Kansai Medical University
2018-2021
Osaka City General Hospital
2015-2017
Takenaka (Japan)
2017
Creative Commons
2015
Christie's
2015
Kinki Central Hospital
2009-2010
The Barbara Ann Karmanos Cancer Institute
2002-2005
Galectin-3 (Gal-3), a member of the beta-galactoside binding protein family containing NWGR antideath motif Bcl-2 family, is involved in various aspects cancer progression. Previously, it has been shown that antiapoptotic activity Gal-3 regulated by phosphorylation at Ser(6) casein kinase 1 (CK1). Here we questioned how regulates function. We have generated serine-to-alanine (S6A) and serine-to-glutamic acid (S6E) mutants transfected them into BT-549 human breast carcinoma cell line, which...
Abstract Galectin-3 (gal-3), a pleiotrophic protein, is an important regulator of tumor metastasis, which like β-catenin shuttles between the nucleus and cytosol in phosphorylation-dependent manner. We report herein that stimulation cyclin D1 c-myc expression gal-3 dependent. Gal-3 binds to β-catenin/Tcf complex, colocalizes with nucleus, induces transcriptional activity Tcf-4 as determined by TOP/FOPFLASH reporter system. have identified β-catenin–gal-3–binding sequences, are NH2 COOH...
The clinical significance of human papillomavirus (HPV) in neck node metastasis from cancer unknown primary (CUP) is not well established. We aimed to address the relationship HPV status between and tumor, also relevance regarding radiographically detected cystic head squamous cell carcinoma (HNSCC) CUP. DNA was examined 68 matched pairs 27 CUPs. In surgically treated CUPs, p16 immunohistochemically. When tonsillectomy proved occult tonsillar CUP, were primary. Cystic on contrast-enhanced...
We aimed to reveal the prevalence and pattern of human papillomavirus ( HPV ) infection p53 mutations among Japanese head neck squamous cell carcinoma HNSCC patients in relation clinicopathological parameters. Human DNA were examined 493 s its subset 283 s. Oropharyngeal was more frequently ‐positive than non‐oropharyngeal (34.4% vs 3.6%, P < 0.001), 16 accounted for 91.1% tumors. In oropharyngeal carcinoma, which showed an increasing trend over time inversely correlated with tobacco...
The incidence of severe mucositis in the oral cavity, pharynx and larynx is high among patients with head neck cancer (HNC) receiving chemoradiotherapy (CRT), resulting significant pain impairment quality life. present study investigated whether L-glutamine (glutamine) decreases severity induced by CRT. This double-blind, randomized, placebo-controlled trial included 40 untreated squamous cell carcinoma nasopharynx, oropharynx, hypopharynx or larynx. Patients received 66 70 Gy total...
Galectin-3 (gal-3), a member of the beta-galactoside-binding proteins family, was identified as binding partner beta-catenin. Analysis human gal-3 sequence reveled structural similarity to beta-catenin it also contains consensus (S92XXXS96) for glycogen synthase kinase-3beta (GSK-3beta) phosphorylation and can serve its substrate. In addition, Axin, regulator protein Wnt that complexes with beta-catenin, binds using same motif here by deletion mutant analysis. The data presented give...
Abstract The antiapoptotic molecule galectin-3 was previously shown to regulate CD95, a member of the tumor necrosis factor (TNF) family proteins in apoptotic signaling pathway. Here, we question generality phenomenon by studying different this [e.g., TNF-related apoptosis-inducing ligand (TRAIL), which induces apoptosis wide variety cancer cells]. Overexpression J82 human bladder carcinoma cells rendered them resistant TRAIL-induced apoptosis, whereas phosphatidylinositol 3-kinase (PI3K)...
Abstract Prostate cancer is one of the malignant tumors which exhibit resistance to anticancer drugs, at least in part due enhanced antiapoptotic mechanisms. Therefore, understanding such mechanisms should improve design chemotherapy against prostate cancer. Galectin-3 (Gal-3), a multifunctional oncogenic protein involved regulation tumor proliferation, angiogenesis, and apoptosis has shown effects certain cell types. Here, we show that expression exogenous Gal-3 human LNCaP cells, do not...
Abstract Studies of CD95 (APO-1/Fas), a member the death receptor family, have revealed that it is involved in two primary apoptotic signaling pathways, one regulated by large amount active caspase-8 (type I) formed at death-inducing complex and other apoptogenic activity mitochondria II). To date, still unclear which pathway will be activated response to an insult. Here, we demonstrate antiapoptotic molecule galectin-3, contains four amino acid-anti-death-motif (NWGR) conserved BH1 domain...
Cancer stem cells (CSCs) are responsible for treatment failure. However, their identification and roles in resistance not well established head neck squamous cell carcinoma (HNSCC). Three HNSCC lines (FaDu, Detroit562 BICR6) were treated with cisplatin or radiation. Cell surface antigens analysed by LyoPlate, a novel antigen array. The expression levels of highly expressed after treatments further compared between cisplatin-resistant its parental line. Association the candidate CSCs...
ABSTRACT Background Patients with head and neck cancer frequently experience malnutrition. The purpose of this study was to examine the impact nutritional status on prognosis its association treatment modalities. Methods This retrospective included 706 patients diagnosed between 2004 2012. effects pretreatment body mass index (BMI) overall survival were analyzed using Kaplan–Meier method Cox regression model. Results BMI ranged from 11.6 38.0 kg/m 2 (median, 21.5) a prognostic factor for...
Abstract A biomarker that is useful for the detection of human papillomavirus (HPV)‐related oropharyngeal cancer (OPC) and unknown primary (CUP) indispensable. We evaluated diagnostic performance HPV DNA mRNA in oral gargle samples circulating tumor HPV16 (ctHPV16DNA) blood samples. Oral were analyzed using commercially available assays GENOSEARCH HPV31 Aptima, respectively. ctHPV16DNA was in‐house droplet digital polymerase chain reaction. Seventy‐four patients with OPC eight CUP included....
Circulating tumor DNA (ctDNA), which circulates in the blood after being shed from cancer cells body, has recently gained attention as an excellent marker. The purpose of this study was to evaluate whether ct human papillomavirus (HPV) 16 (ctHPV16DNA) levels were associated with quantitative PET parameters patients HPV-positive head and neck (HN) squamous cell carcinoma (SCC). Fifty oropharyngeal SCC (OPSCC) 5 unknown primary (SCCUP) before treatment included. They all underwent sampling...
Abstract Purpose Chemoradiotherapy (CRT) for head and neck cancer (HNC) often causes dysphagia. The risk of dysphagia increases during CRT tends to become more severe after finishing CRT, persists a few weeks thereafter. Thus, understanding the changes in swallowing physiology immediately is essential. This study aimed clarify response early identify associated factors. Methods retrospective enrolled 107 patients with HNC who underwent CRT. We measured pharyngeal delay time (PDT) laryngeal...
Integration of human papillomavirus (HPV) into the host genome drives HPV-positive head and neck squamous cell carcinoma (HPV+ HNSCC). Whole-genome sequencing 51 tumors revealed intratumor heterogeneity HPV integration, with 44% breakpoints subclonal, a biased distribution integration across genome. Four physical states were identified, at least 49% progressing without integration. was associated APOBEC-induced broad genomic instability focal instability, including structural variants sites....