A5107934331- Osteoarthritis Treatment and Mechanisms
- Total Knee Arthroplasty Outcomes
- Advanced biosensing and bioanalysis techniques
- Cancer, Hypoxia, and Metabolism
- Peroxisome Proliferator-Activated Receptors
- Inflammatory mediators and NSAID effects
- Cancer, Lipids, and Metabolism
- Orthopaedic implants and arthroplasty
- Nerve injury and regeneration
- Circular RNAs in diseases
- Chemokine receptors and signaling
- Metabolomics and Mass Spectrometry Studies
- HIV, Drug Use, Sexual Risk
- Nanoplatforms for cancer theranostics
- Orthopedic Infections and Treatments
- Bone Tissue Engineering Materials
- HIV/AIDS Research and Interventions
- Catalytic Processes in Materials Science
- Geotechnical Engineering and Soil Mechanics
- Electrospun Nanofibers in Biomedical Applications
- Bone Metabolism and Diseases
- Acute Lymphoblastic Leukemia research
- RNA Interference and Gene Delivery
- Organ and Tissue Transplantation Research
- Biosensors and Analytical Detection
Peking University Shenzhen Hospital
2022-2025
Shenzhen University
2023-2025
First Affiliated Hospital Zhejiang University
2023-2025
Shenzhen Second People's Hospital
2024-2025
China Social Welfare Foundation
2024
Air Force Medical University
2024
Binzhou Medical University
2024
Zhejiang University
2023-2024
Chinese Academy of Sciences
2024
Liuzhou General Hospital
2024
Abstract Intra-articular injection of therapeutics is an effective strategy for treating osteoarthritis (OA), but it hindered by rapid drug diffusion, thereby necessitating high-frequency injections. Hence, the development a biofunctional hydrogel improved delivery required. In this study, we introduce liposome-anchored teriparatide (PTH (1–34)) incorporated into gallic acid-grafted gelatin injectable (GLP hydrogel). We show that GLP can form in situ and without affecting knee motion after...
Diabetic sarcopenia (DS) is characterized by muscle atrophy, slower nerve conduction, reduced maximum tension generated skeletal contraction, and contraction rate. Hence, DS can cause limb movement degeneration, slow movement, balance, metabolic rate, falls, fractures, etc. Moreover, the relevant early biological metabolites their pathophysiological mechanism have yet to be characterized.The current cross-sectional study employed serum metabolomics analysis screen potential noninvasive...
Abstract Background A former cohort study has raised concern regarding the unanticipated hazard of omeprazole in expediting osteoarthritis (OA) advancement. The precise nature their causal evidence, however, remains undetermined. present research endeavors to investigate underlying link between and OA through application mendelian randomization (MR) analysis. Methods incorporated ukb-a-106 ukb-b-14,486 datasets. investigation effects employed methodologies such as MR-Egger, Weighted median,...
Abstract Peripheral nerve disease is commonly encountered in orthopedics, neurology, and neurosurgery. Due to its large population, a substantial number of patients are affected by these conditions China. has high disability rate current treatments show poor clinical efficacy, resulting heavy burden for the country's healthcare system. Defensins widespread proteins, found animals, plants, fungi, with multiple subtypes able kill variety pathogens. As regulatory factors immune system,...
Background: To evaluate the value and challenges of real-world clinical application metagenomic next-generation sequencing (mNGS) for bronchoalveolar lavage fluid (BALF) in HIV-infected patients with suspected multi-pathogenic pneumonia. Methods: Fifty-seven mixed pneumonia who were agreed to undergo bronchoscopy recruited retrospectively reviewed results mNGS conventional microbiological tests (CMTs) BALF from July 2020 June 2022. Results: 54 diagnosed including 49 definite pathogens five...
Osteoarthritis is a chronic degenerative disease based on the degeneration and loss of articular cartilage. Inflammation aging play an important role in destruction extracellular matrix, which microRNA (miRNA) key point, such as miRNA-34a-5p. Upregulation miRNA-34a-5p was previously reported rat OA model, its inhibition significantly suppressed interleukin (IL)-1β-induced apoptosis chondrocytes. However, Oxidative stress caused by reactive oxygen species (ROS) can exacerbate progression...
A chain-shattering polymeric SO 2 prodrug micelle system was fabricated for effective delivery and redox-triggered based gas therapy of osteosarcoma.
Knee osteoarthritis (KOA) is a highly prevalent musculoskeletal disorder characterized by degeneration of cartilage and abnormal remodeling subchondral bone (SCB). Teriparatide (PTH (1-34)) an effective anabolic drug for osteoporosis (OP) regulates osteoprotegerin (OPG)/receptor activator nuclear factor ligand (RANKL)/RANK signaling, which also has therapeutic effect on KOA ameliorating degradation inhibiting aberrant SCB. However, the mechanisms PTH (1-34) in treating are still uncertain...
Infiltration of tumor-associated macrophages (TAMs) can promote tumorigenesis and development. C-C motif chemokine ligand 3 (CCL3) was reported to be derived from TAMs tumor cells facilitate the progression several cancers. Nevertheless, whether CCL3 colon adenocarcinoma (COAD) is unclarified. Peripheral blood monocytes-derived were polarized by conditioned medium COAD establish TAM-like (TAM1/2). RT-qPCR western blotting used for detection expression levels its receptors receptor 1 (CCR1)...
Polypropylene (PP)/sepiolite nanocomposites were prepared using the melt blending technique. The effects of nano-sepiolite content on mechanical property, thermal crystallinity, morphology and rheological property PP/sepiolite investigated. organic modified sepiolites (OSep) dispersed evenly in PP matrix after surface treatment. addition OSep improved storage modulus stability, showing a strong interaction between matrix. With increase content, fluidity PP/OSep composites first increased due...
Osteoporotic fractures are induced by osteoporosis, which may lead to the degradation of bone tissues and microstructures impair their healing ability. Conventional internal fixation therapies ineffective in treatment osteoporotic fractures. Hence, developing tissue engineering materials is crucial for repairing It has been demonstrated that nanomaterials, particularly graphene oxide (GO), possess unique advantages due excellent biocompatibility, mechanical properties, osteoinductive...
d-Pinitol (DP) is primarily found in