Abstract Osteoarthritis (OA) is a degenerative disease caused by variety of factors with joint pain as the main symptom, including fibrosis, chapping, ulcers, and loss cartilage. Traditional treatment can only delay progression OA, classical delivery system have many side effects. In recent years, microspheres shown great application prospects in field OA treatment. Microspheres support cells, reproduce natural tissue microenvironment vitro vivo, are an efficient for release drugs or...

Abstract Osteoarthritis (OA), known as one of the most common types aseptic inflammation musculoskeletal system, is characterized by chronic pain and whole-joint lesions. With cellular molecular changes including senescence, inflammatory alterations, subsequent cartilage defects, OA eventually leads to a series adverse outcomes such disability. CRISPR-Cas-related technology has been proposed explored gene therapy, offering potential gene-editing tools that are in spotlight. Considering...

Nanoparticles (NPs) are currently under intensive research for their application in tumor diagnosis and therapy. X-ray fluorescence computed tomography (XFCT) is considered a promising non-invasive imaging technique to obtain the bio-distribution of nanoparticles which include high-Z elements (e.g., gadolinium (Gd) or gold (Au)). In present work, set experiments with quantitative GdNPs mice were performed using our benchtop XFCT device. solution consists 20 mg/mL NaGdF4 was injected into...

This study aimed to evaluate the health-related quality of life (HRQoL) in ankylosing spondylitis (AS) patients Chaoshan region and identify factors influencing ASAS Health Index (ASAS-HI) enhance comprehensive AS treatment strategies. A survey ASAS-HI was conducted on 82 from rheumatology outpatient department First Affiliated Hospital Shantou University Medical College. The Bath Ankylosing Spondylitis Global Score (BAS-G) assessed overall health status, Quality Life Questionnaire (AS-QOL)...

A nanostrategy that combines bright core–shell probes, a nanomixing chip, and machine learning was proposed to evaluate the clinical performance of plasma EV phenotypes in differentiating early-stage lung cancer benign diseases.

Osteoporotic fractures are induced by osteoporosis, which may lead to the degradation of bone tissues and microstructures impair their healing ability. Conventional internal fixation therapies ineffective in treatment osteoporotic fractures. Hence, developing tissue engineering materials is crucial for repairing It has been demonstrated that nanomaterials, particularly graphene oxide (GO), possess unique advantages due excellent biocompatibility, mechanical properties, osteoinductive...

Abstract The face image data collected by ordinary recognition system is usually static. In real life, to fully capture the state information of human emotion change, we need collect dynamic expression change data, which needs a video sequence reflect process change. this paper, combine ResNet residual neural network and long-term memory (LSTM) extract features from sequences then recognize them. network, element has very good effect on training optimization deep CNN model, shortens...

Rectal cancer (RC) is one of the most common cancers throughout world. Chemotherapy or neoadjuvant chemotherapy play an important role in treatment advanced RC. Whether to add topoisomerase inhibitor individualized a puzzling question for clinicians.To investigate whether pretreatment MR-based radiomics signature can assess expression II alpha (TOPO-IIα) RC.Retrospective.In all, 122 patients with Field Strength/Sequence: Pretreatment 3.0T; T2 WI turbo spin echo (TSE) sequence.A training...

Abstract Objective To investigate the correlations and feasibility of diffusion kurtosis imaging (DKI) parameters tumour histopathology after radiotherapy in human nasopharyngeal carcinoma (NPC) xenografts on nude mice. Materials Methods Seventy-two mice were used for construction CNE-1 (radio-insensitive) CNE-2 (radio-sensitive) NPC xenograft models, followed by fraction irradiation at different doses X-ray. The randomly divided into six groups each cell line models according to dose X-ray...

Abstract Purpose: This study aims to elucidate emerging trends, dynamic advancements, and research focal points in exosome-mediated repair regeneration of cartilage damage over the past decade, employing a visualization approach. Methods: A total 300 records focusing on utilization exosomes were systematically gathered from Web Science Core Collection (WoSCC) database spanning years 2013 2023. Utilizing R language, VOSviewer, CiteSpace, GraphpadPrism software, we conducted analyses general...

With the continuous development of information technology, our country has achieved great progress and in Electronic Science technology. Nowadays mobile embedded systems are gradually coming into people's vision. Mobile system is a brand-new computer technology current Now it been widely used enterprises. extends its functions mainly by combining access capability Internet. Nowadays, network welcomed people. But for network, there also variety attacks. Therefore, research process this paper,...

Traditional convolutional neural network classification models often only focus on the most distinguishing feature regions of image and ignore weaker regions. However, position distribution plant diseases is very uneven. If we use for disease recognition, there will be insufficient response, which cause recognition errors. Aiming at such problems, have designed a deep complementary network. First, uses DeepLabv3+ Conditional Random Field (CRF) to generate part detection frames in weakly...

Objective To investigate the peri-nasopharyngeal invasion patterns of nasopharyngeal carcinoma (NPC) on MRI and its relationship with tumor staging. Methods One thousand five hundred seventy-three patients newly diagnosed NPC which were histo-pathologically proved retrospectively studied. The manifestations NPCs elevated according to 2008 Tstaging system NPC. Z test was used analyze rate adjacent structures in NPCs. Results invaded by included pharyngobasilar fascia 1299 cases (82. 58% );...

Computed tomography (CT) is the preferred method for evaluating therapeutic effect of lung cancer. Radiomics parameters can provide a lot supplementary information clinical diagnosis and treatment.To investigate value radiomics features CT imaging to predict evaluate early efficacy chemotherapy in patients with advanced adenocarcinoma.A total 101 adenocarcinoma were enrolled. Patients classified into response group non-response according RECIST 1.1 standard. All underwent chest examination...