A5049709983- Endometrial and Cervical Cancer Treatments
- Colorectal and Anal Carcinomas
- Interstitial Lung Diseases and Idiopathic Pulmonary Fibrosis
- Ovarian cancer diagnosis and treatment
- Food Quality and Safety Studies
- Autophagy in Disease and Therapy
- Adrenal and Paraganglionic Tumors
- Cervical Cancer and HPV Research
- Cancer, Hypoxia, and Metabolism
- Cancer Risks and Factors
- Ginseng Biological Effects and Applications
- Management of metastatic bone disease
- Cardiovascular Function and Risk Factors
- Parkinson's Disease Mechanisms and Treatments
- Metabolism, Diabetes, and Cancer
- Nutrition and Health in Aging
- Radiomics and Machine Learning in Medical Imaging
- Cardiac Fibrosis and Remodeling
- Advanced Glycation End Products research
- Cancer Diagnosis and Treatment
- Metastasis and carcinoma case studies
- Pancreatic function and diabetes
- Diabetes and associated disorders
- Inflammatory Biomarkers in Disease Prognosis
- Body Composition Measurement Techniques
First Hospital of Jilin University
2025
Jilin University
2025
Qilu Hospital of Shandong University
2009-2024
North University of China
2024
Shanghai Clinical Research Center
2023-2024
Shandong University
2013-2024
Chinese Academy of Medical Sciences & Peking Union Medical College
2012
Peking Union Medical College Hospital
2012
British Geriatrics Society
2012
The construction of the industrial Internet platform is key to digital, networked and intelligent transformation innovation manufacturing industry. At present, there are some limitations in research on mechanism with participation developers. It fails consider reasonable benefit sharing coefficient influence decision-making process form strength government support. Therefore, a four party dynamic interactive evolutionary game model based logical framework "government enterprise developer"...
Diabetic sarcopenia (DS) is characterized by muscle atrophy, slower nerve conduction, reduced maximum tension generated skeletal contraction, and contraction rate. Hence, DS can cause limb movement degeneration, slow movement, balance, metabolic rate, falls, fractures, etc. Moreover, the relevant early biological metabolites their pathophysiological mechanism have yet to be characterized.The current cross-sectional study employed serum metabolomics analysis screen potential noninvasive...
Abstract Background Diabetic sarcopenia is a disease‐related skeletal muscle disorder that causes progressive symptoms. The complete understanding of its pathogenesis yet to be unravelled, which makes it difficult develop effective therapeutic strategies. This study investigates how MFG‐E8 affects mitophagy and the protective role D‐pinitol (DP) in diabetic sarcopenia. Methods In vivo, streptozotocin‐induced SAM‐R1 (STZ‐R1) SAM‐P8 (STZ‐P8) mice (16‐week‐old) were used, STZ‐P8 administrated...
Abstract Background Glucose metabolism plays a critical role in tumor progression. When glucose intake is insufficient and the tumor’s growth rate exceeds its energy supply, cells typically adapt overcome stress through compensatory mechanisms to maintain survival of cells, which may also be related recurrence or metastasis. Methods Different concentrations were selected as basis for model gastric cancer. Then CCK-8 flow cytometry used detect effects on cell proliferation, apoptosis, cycle....
Objective: To assess the toxicity of delivering extended field intensity-modulated radiotherapy (EF-IMRT) and concurrent cisplatin chemotherapy for locally advanced cervical carcinoma.Methods: Forty-five patients who underwent EF-IMRT treatment stage IB2 to IIIB cancer were retrospectively reviewed.The clinical target volume included all areas gross potentially microscopic disease regional lymph node regions.All high-dose-rate brachytherapy.The acute late scored using Common Terminology...
The progression of diabetic cardiomyopathy is related to cardiomyocyte dysfunction and apoptosis. Our previous studies showed that asporin (ASPN) was significantly increased in the myocardium db/db mice through proteomics, grape seed procyanidin B2 (GSPB2) inhibited expression ASPN heart mice. We report here played a critical role glycated low-density lipoproteins (gly-LDL) induced-cardiomyocyte found gly-LDL upregulated expression. H9C2 apoptosis with down-regulation Bcl-2, upregulation...
In this paper, we provide a deep dive into the deployment of inference accelerators at Facebook. Many our ML workloads have unique characteristics, such as sparse memory accesses, large model sizes, well high compute, and network bandwidth requirements. We co-designed high-performance, energy-efficient accelerator platform based on these describe ecosystem developed deployed Facebook: both hardware, through Open Compute Platform (OCP), software framework tooling, Pytorch/Caffe2/Glow. A...
Abstract Background Pulmonary fibrosis (PF) is a chronic and potentially fatal lung disease disorder. Although the active ingredients of ginseng honeysuckle superfine powdered tea (GHSPT) have been proven to anti-inflammatory antioxidant effects, mechanism GHSPT on PF remains unclear. The present study was explore underlying in treating based proteomics network pharmacology analysis confirm it vivo. Materials methods We used intratracheal instillation bleomycin induce mouse model (640 mg/kg)...
Diabetic cardiomyopathy (DCM) causes heart failure and increases the mortality in diabetic patients. Myocardial apoptosis fibrosis are main features of DCM aging. The aim is to study underlying mechanism D-pinitol (DP) on myocardial an elderly mouse model. model was established by SAMP-8 mice that were injected with streptozotocin daily for five consecutive days. administrated DP (150 mg kg−1 day−1) gavage 10 weeks. common metabolic disorder indices, cardiac dysfunction, oxidative stress,...
Proline/arginine-rich end leucine-rich repeat protein (PRELP) has been reported to contribute the remodelling of cardiovascular tissues in ischaemia-reperfusion injury model. However, research is lacking on role PRELP myocardial fibrosis and ventricular remodelling, mechanism through which brings about these changes not clear. This study aimed evaluate following acute infarction (AMI) explore underlying mechanism.In this study, we established AMI mouse cellculture models an oxygen-glucose...
Pulmonary hypertension (PH) is a common disease that affects the normal functioning of human pulmonary arteries. The peripheral blood mononuclear cells (PMBCs) served as an ideal source for minimally invasive diagnosis. This study hypothesized transcriptional fluctuations in PMBCs exposed to PH arteries may stably reflect disease. However, dimension transcriptome much higher than number samples all existing datasets. So, ensemble feature selection algorithm, EnRank, was proposed integrate...
Objective: The goal of this study was to confirm the clinical value pretreatment serum squamous cell carcinoma antigen (SCC-Ag) in administration consolidation chemotherapy patients with cervical cancers undergoing postoperative extended-field radiotherapy (EFRT) and concurrent (CCRT). Methods: Between 2007 2018, a total 113 were treated intensity-modulated (EF-IMRT) CCRT. There 63 receiving chemoradiotherapy (EF-CCRT) chemotherapy, while another 50 underwent EF-CCRT alone. For planning...
Low-grade inflammation is one of the characteristics metabolic disorders induced by diabetes mellitus. The present study explores underlying mechanism milk fat globule epidermal growth factor 8 (MFG-E8) on necroptosis-induced intestinal and epithelial endocrine cell dysfunction in diabetes. Compared with normal control group, pathological changes such as blunt shortened villus denuded tips were observed ileum tissue streptozotocin (STZ) senescence-resistant 1 (SAMR1) senescence-accelerated...
For early-stage cervical cancer patients experiencing radical surgery, postoperative radiotherapy was recommended for with a combination of intermediate-risk factors. However, there no consensus on whether to administer concurrent chemotherapy. The aim the study confirm clinical value controlling nutritional status (CONUT) score in guiding use chemotherapy during radiotherapy.A total 969 FIGO stage IB-IIA were retrospectively analyzed. Kaplan-Meier survival analysis performed compare...
Abstract Objective The aim of the present study was to retrospectively evaluate toxicity and efficacy post-operative small pelvic intensity-modulated radiotherapy in early-stage cervical cancer patients with intermediate-risk factors. Methods Between 2012 2016, 151 who had (International Federation Gynecology Obstetrics stage I–IIA) factors were treated radiotherapy. median dose 50.4 Gy 28 fractions prescribed planning target volume. technique used conventional fixed-field or helical...
Studies determining which early-stage cervical cancer patients with high-risk factors benefit from consolidation chemotherapy after postoperative concurrent chemoradiotherapy (CCRT) are limited and inconsistent. The aim of this study was to evaluate the value in cancer.From 2010 2019, a retrospective review conducted among who were treated CCRT or CCRT. Disease-free survival (DFS) overall (OS) calculated using Kaplan-Meier method compared log-rank test.A total 293 included study. A 188...
Abstract Diabetic cardiomyopathy (DCM) is an important complication resulting in heart failure and death of diabetic patients. However, there no effective drug for treatments. This study investigated the effect D‐pinitol (DP) on cardiac injury using mice glycosylation cardiomyocytes its molecular mechanisms. We established streptozotocin‐induced SAMR1 SAMP8 DP (150 mg/kg/day) intragastrically advanced glycation end‐products (AGEs)‐induced H9C2 cells. cells were transfected with optineurin...
The molecular mechanisms of diabetic cardiomyopathy (DCM) development and D-pinitol (DP) in its treatment remain unclear. present study is to explore the underlying mechanism DCM an elderly mouse model seek protective targets DP by phosphoproteomics.We used streptozotocin induce diabetes SAMP8 (150 mg/kg/day) intragastrically administrated mice for 8 weeks. heart tissues were harvested label-free phosphoproteomic analysis from mice. Some differentially regulated phosphorylation sites...
Background: Studies determining which patients with International Federation of Gynecology and Obstetrics (FIGO) stage IIIB disease benefit from prophylactic extended-field irradiation (EFRT), can reduce para-aortic lymph node (PALN) failure rates, are limited. The study was designed to evaluate the value controlling nutritional status (CONUT) score as a risk factor for predicting PALN recurrence identifying potential indications EFRT. Methods: From 2010 2015, retrospective review conducted...