A5100322776- Osteoarthritis Treatment and Mechanisms
- Inflammatory mediators and NSAID effects
- Urinary Bladder and Prostate Research
- Pelvic floor disorders treatments
- Folate and B Vitamins Research
- Anorectal Disease Treatments and Outcomes
- NF-κB Signaling Pathways
- Knee injuries and reconstruction techniques
- interferon and immune responses
- Rheumatoid Arthritis Research and Therapies
- Bone Tumor Diagnosis and Treatments
- Chemokine receptors and signaling
- Immune Response and Inflammation
- IgG4-Related and Inflammatory Diseases
- Cytokine Signaling Pathways and Interactions
- Protease and Inhibitor Mechanisms
- Amyloidosis: Diagnosis, Treatment, Outcomes
- Galectins and Cancer Biology
- Adipokines, Inflammation, and Metabolic Diseases
- Spondyloarthritis Studies and Treatments
- Diet, Metabolism, and Disease
- Nutrition and Health in Aging
- HIV-related health complications and treatments
- Musculoskeletal synovial abnormalities and treatments
- Total Knee Arthroplasty Outcomes
Nanjing University
2024
Nanjing General Hospital of Nanjing Military Command
2024
Nanjing Medical University
2024
Second Affiliated Hospital of Nanjing Medical University
2024
China Medical University
2018-2023
Beijing University of Chinese Medicine
2023
Union Hospital
2007-2022
Jilin University
2018-2022
Huazhong University of Science and Technology
2007-2022
First Affiliated Hospital of Xinjiang Medical University
2021-2022
Ankylosing Spondylitis (AS) is a chronic inflammatory disorder which can lead to considerable pain and disability. Mendelian randomization (MR) has been extensively applied for repurposing licensed drugs uncovering new therapeutic targets. Our objective pinpoint innovative protein targets AS assess the potential adverse effects of druggable proteins.
Abstract Mechanical stress plays a key role in regulating cartilage degradation osteoarthritis (OA). The aim of this study was to evaluate the effects and mechanisms mechanical on articular cartilage. A total 80 male Sprague‐Dawley rats were randomly divided into eight groups ( n = 10 for each group): control group (CG), OA (OAG), CG or OAG subjected low‐, moderate‐, high‐intensity treadmill exercise (CL, CM, CH, OAL, OAM, OAH, respectively). Chondrocytes obtained from knee joints rats; they...
Osteoarthritis (OA) is a degenerative disease that difficult to cure owing its complicated pathogenesis. Exercise therapy has been endorsed as primary treatment option. However, it remains controversial how exercise intensity regulates OA progression. Here, declining propensity for TGF-β1 was predicted via bioinformatics analysis of microarray GSE57218 and validated in cartilage samples obtained from arthroplasty. Based on this, cyclic tensile strain or intervention performed human...
Heracleum moellendorffii Hance is a perennial herbaceous plant that adaptable to cold environments and has both edible medicinal value. Given no reference genome for this species available, we constructed high-quality transcript isoform library using full-length transcriptome sequencing conducted comparative genomic analysis. Samples were obtained from plants had been subjected stress 12, 24 36 hours (Cold_12, Cold_24, Cold_36, respectively) control (Cold_0) not used in nontargeted...
Osteoarthritis (OA) is a degenerative joint disease with multiple etiologies that affects individuals worldwide. No effective interventions are currently available to reverse the pathological process of OA. Sodium butyrate (NaB), component short-chain fatty acids (SCFAs), has biological activities, including attenuation inflammation and anti-tumor activities in various diseases. However, whether protective effects NaB OA associated promotion autophagy had not been investigated. Here, we...
Lipoxin A4 (LXA4), a kind of adipokines, is potent stop signal inflammation. Our preliminary study found that LXA4 serum and intra-articular lavage fluid (IALF) was rapidly elevated in 2 h reduced to normal level at 4 after moderate-intensity treadmill exercise. The aim confirm the therapeutic effects during exercise on rat model monosodium iodoacetate (MIA)-induced OA detailed mechanism OA. One hundred twenty-four male Sprague-Dawley rats were submitted two different protocols. A single...
A hallmark of osteoarthritis is increased proteolytic cleavage aggrecan. Cross talk between cartilage and the synovium + joint capsule (SJC) can drive degradation by activating proteases in both tissues. We investigated aggrecan proteolysis patterns explants using a physiologically relevant explant model injury combining mechanical compression coincubation with SJC. Bovine were untreated; coincubated SJC; or subjected to SJC, alone, incubated tumor necrosis factor-α (TNF-α). To compare 6 h...
Active matrix metalloproteases (MMPs) play a significant role in the pathogenesis of many diseases including osteoarthritis (OA), which involves progressive proteolytic degradation cartilage. Clinical success OA interventions that target MMPs has been limited by lack information about presence and activity specific disease-related proteases. We therefore developed chemoproteomics approach based on MS to characterize release an vitro model early inflammatory phase posttraumatic (PTOA)....
The noncollagenous interfibrillar interface in bone provides the critical function of transferring loads among collagen fibrils and their bundles, with adhesive mechanisms at this site thus significantly contributing to mechanical properties bone. Motivated by experimental observations hypotheses, a computational study is presented elucidate roles two major proteins nanoscale interface, that is, osteopontin (OPN) osteocalcin (OC) This reveals extremely high interfacial toughness OPN/OC...
In this exploratory study, we used discovery proteomics to follow the release of proteins from bovine knee articular cartilage in response mechanical injury and cytokine treatment. We also studied effect glucocorticoid Dexamethasone (Dex) on these responses.Bovine explants were treated with either cytokines alone (10 ng/ml TNFα, 20 IL-6, 100 sIL-6R), a single compressive injury, or no treatment, cultured serum-free DMEM supplemented 1% ITS for 22 days. All samples incubated without addition...
In this study, we apply a clustering method to proteomic data sets from bovine and human models of post-traumatic osteoarthritis (PTOA) distinguish clusters proteins based on their kinetics release cartilage examined these groups for PTOA biomarker candidates. We then quantified the effects dexamethasone (Dex) media proteome.Mass spectrometry was performed sample medium collected two separate experiments using juvenile explants (3 samples/treatment condition) during 20- or 21-day treatment...
In women with mixed urinary incontinence, pelvic floor muscle training and solifenacin is the recommended conservative treatment, while electroacupuncture a safe, economical effective option. this prospective, multi-center, randomized controlled trial, five hundred from 10 centers will be to receive either or plus solifenacin. Women in acupuncture group for 3 sessions per week, over 12 weeks, control (5 mg once daily) 36 weeks. The primary outcome measure proportion of change 72-hour...
Abstract A 49-year-old woman complained of right upper back pain for 1 month. Serum tests showed increased erythrocyte sedimentation rate. Thoracic spinal MRI an epidural lesion at the T1–T4 level with inhomogeneous signal intensity on T2-weighted images, slightly higher than cord T1-weighted and remarkable enhancement enhanced images. Epidural malignant tumor was suspected. FDG PET/CT performed showing uptake extending to T1–T2 T2–T3 neural foramina. decompressive posterior thoracic...
The CSPPT (China Stroke Primary Prevention Trial) demonstrated a significant risk reduction of first stroke in hypertensive patients treated with enalapril plus folic acid compared those alone, but the lifetime stroke-free survival associated treatment is unknown. By establishing adjusted models for competing risks and an age-based time scale using data from 19 053 participants CSPPT, we estimated incremental enalapril-folic versus alone. Compared projected mean gain 1.75 months,...