A5007741766- Renin-Angiotensin System Studies
- Hormonal Regulation and Hypertension
- Insect-Plant Interactions and Control
- Insect Resistance and Genetics
- Nitric Oxide and Endothelin Effects
- Acute Kidney Injury Research
- Inflammasome and immune disorders
- Chronic Kidney Disease and Diabetes
- Receptor Mechanisms and Signaling
- Eicosanoids and Hypertension Pharmacology
- Renal Diseases and Glomerulopathies
- Insect and Pesticide Research
- Metabolism and Genetic Disorders
- Neuropeptides and Animal Physiology
- Cell death mechanisms and regulation
- Molecular Biology Techniques and Applications
- Renal and related cancers
- CRISPR and Genetic Engineering
- Autophagy in Disease and Therapy
- Biomedical Research and Pathophysiology
- Digestive system and related health
- Nuclear Receptors and Signaling
- Heme Oxygenase-1 and Carbon Monoxide
- Heavy Metal Exposure and Toxicity
- Forest, Soil, and Plant Ecology in China
Fudan University
2013-2024
Shanghai Medical College of Fudan University
2010-2024
Children's Hospital of Fudan University
2024
Huashan Hospital
2023-2024
Pudong New Area People's Hospital
2021
State Key Laboratory of Medical Neurobiology
1997-2020
Cotton Research Institute
2014-2018
Chinese Academy of Agricultural Sciences
2008-2018
Chinese Academy of Sciences
1996-2017
Shanghai Institutes for Biological Sciences
2008-2017
Abstract Although extracellular DNA is known to form immune complexes (ICs) with autoantibodies in systemic lupus erythematosus (SLE), the mechanisms leading release of from cells remain poorly characterized. Here, we show that pore-forming protein, gasdermin D (GSDMD), required for nuclear and mitochondrial (mtDNA) neutrophils lytic cell death following ex vivo stimulation serum patients SLE IFN-γ. Mechanistically, activation FcγR downregulated Serpinb1 SLE, spontaneous both...
MicroRNAs are endogenous repressors of gene expression. We examined microRNAs in the renal medulla Dahl salt-sensitive rats and consomic SS-13(BN) rats. Salt-induced hypertension injury rats, particularly medullary interstitial fibrosis, have been shown previously to be substantially attenuated Of 377 examined, 5 were found differentially expressed between receiving a high-salt diet. Real-time PCR analysis demonstrated that diets induced substantial upregulation miR-29b but not SS was...
Hypertension remains to be a global public health burden and demands novel intervention strategies such as targeting T cells T-cell-derived cytokines. Mineralocorticoid receptor (MR) antagonists have been clinically used treat hypertension. However, the function of T-cell MR in blood pressure (BP) regulation has not elucidated.We aim determine role BP explore mechanism.Using knockout mouse combination with angiotensin II-induced hypertensive model, we demonstrated that deficiency strikingly...
Abstract Aryl hydrocarbon receptor (AhR) was originally identified as an environmental sensor that responds to pollutants. Subsequent research has revealed AhR recognizes multiple exogenous and endogenous molecules, including uremic toxins retained in the body due decline renal function. Therefore, is also considered be a toxin receptor. As ligand-activated transcriptional factor, activation of involved cell differentiation senescence, lipid metabolism fibrogenesis. The accumulation...
Abstract Berberine (BBR), an isoquinoline alkaloid derived from plants, is widely used as anti-inflammatory remedy in traditional Chinese medicine. In this study, we showed that BBR was efficacious the amelioration of experimental autoimmune encephalomyelitis (EAE) through novel regulatory mechanisms involving pathogenic Th1 and Th17 cells. inhibited differentiation cells and, to a lesser degree, direct actions on JAK/STAT pathway, whereas it had no effect relative number CD4+Foxp3+ T...
Decrease in endogenous hydrogen sulfide (H2S) was reported to participate the pathogenesis of diabetic nephropathy (DN). This study is aimed at exploring relationship between abnormalities H2S metabolism, hyperglycemia-induced oxidative stress and activation intrarenal renin-angiotensin system (RAS). Cultured renal mesangial cells (MCs) streptozotocin (STZ) induced rats were used for studies. The expressions angiotensinogen (AGT), angiotensin converting enzyme (ACE), II (Ang II) type I...
Renal fibrosis is the final common pathway of chronic kidney disease (CKD), and no effective medication available clinically for managing its progression. Metformin was initially developed as an anti-diabetic drug recently gained attention potential in treatment other diseases. In this study, we investigated effects on renal a mouse model unilateral ureteral obstruction (UUO) vivo angiotensin II (Ang II)-treated fibroblast NRK-49F cells vitro. Our data showed that UUO induced combined with...
Chronic kidney disease is associated with higher risk of cardiovascular complication and this interaction can lead to accelerated dysfunction in both organs. Renalase, a kidney-derived cytokine, not only protects against various renal diseases but also exerts cardio-protective effects. Here, we investigated the role renalase progression cardiorenal syndrome (CRS) after subtotal nephrectomy. Sprague-Dawley rats were randomly subjected sham operation or (5/6) nephrectomy (STNx). Two weeks...
Retention of metabolic end-products in the bodily fluids patients with chronic kidney disease (CKD) may lead to uremia. The uremic toxin indoxyl sulfate (IS), a tryptophan metabolite, is an endogenous ligand aryl hydrocarbon receptor (AhR). It clarified that upregulation and activation AhR by IS tubular epithelial cells (TECs) promote renal senescence fibrosis. Renal TEC-specific knockout attenuates fibrosis, as well suppression PGC1α-mediated mitochondrial biogenesis ischemia reperfusion...
Abstract Berbamine (BM) is an herbal compound derived from Berberis vulgaris L commonly used in traditional Chinese medicine. In this study, we show that BM has potent anti-inflammatory properties through novel regulatory mechanisms, leading to reduced encephalitogenic T cell responses and amelioration of experimental autoimmune encephalomyelitis (EAE). The treatment effect was attributable its selective inhibitory on the production action IFN-γ CD4+ cells, which mediated altered STAT4...
Abstract The activation of Wnt/β‐catenin pathway plays a pivotal role in promoting renal fibrosis. relies on the binding Wnts to Frizzled receptors cell membrane. However, factor regulating production remains unclear. Here, we demonstrated that transcriptional FoxM1 was significantly increased obstructed kidneys and patients' with up‐regulation mainly distributed tubular epithelial cells. Pharmacological inhibition down‐regulated multi‐Wnts elevation UUO mice attenuated In cultured cells,...